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Results: 1 to 20 of 116

1.

The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels.

Bende NS, Kang E, Herzig V, Bosmans F, Nicholson GM, Mobli M, King GF.

Biochem Pharmacol. 2013 May 15;85(10):1542-54. doi: 10.1016/j.bcp.2013.02.030. Epub 2013 Mar 6.

PMID:
23473802
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Insect-selective spider toxins targeting voltage-gated sodium channels.

Nicholson GM.

Toxicon. 2007 Mar 15;49(4):490-512. Epub 2006 Dec 5. Review.

PMID:
17223149
[PubMed - indexed for MEDLINE]
3.

Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana.

Liu Z, Cai T, Zhu Q, Deng M, Li J, Zhou X, Zhang F, Li D, Li J, Liu Y, Hu W, Liang S.

J Biol Chem. 2013 Jul 12;288(28):20392-403. doi: 10.1074/jbc.M112.426627. Epub 2013 May 23.

PMID:
23703613
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana.

Li D, Xiao Y, Hu W, Xie J, Bosmans F, Tytgat J, Liang S.

FEBS Lett. 2003 Dec 18;555(3):616-22.

PMID:
14675784
[PubMed - indexed for MEDLINE]
Free Article
5.

Jingzhaotoxin-I, a novel spider neurotoxin preferentially inhibiting cardiac sodium channel inactivation.

Xiao Y, Tang J, Hu W, Xie J, Maertens C, Tytgat J, Liang S.

J Biol Chem. 2005 Apr 1;280(13):12069-76. Epub 2004 Nov 17.

PMID:
15548530
[PubMed - indexed for MEDLINE]
Free Article
6.

Inhibition of insect calcium channels by huwentoxin-V, a neurotoxin from Chinese tarantula Ornithoctonus huwena venom.

Deng M, Luo X, Meng E, Xiao Y, Liang S.

Eur J Pharmacol. 2008 Mar 17;582(1-3):12-6. doi: 10.1016/j.ejphar.2007.12.014. Epub 2007 Dec 27.

PMID:
18234186
[PubMed - indexed for MEDLINE]
7.

Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena.

Peng K, Shu Q, Liu Z, Liang S.

J Biol Chem. 2002 Dec 6;277(49):47564-71. Epub 2002 Sep 11. Erratum in: J Biol Chem. 2003 Feb 14;278(7):5489..

PMID:
12228241
[PubMed - indexed for MEDLINE]
Free Article
8.

The structure of a novel insecticidal neurotoxin, omega-atracotoxin-HV1, from the venom of an Australian funnel web spider.

Fletcher JI, Smith R, O'Donoghue SI, Nilges M, Connor M, Howden ME, Christie MJ, King GF.

Nat Struct Biol. 1997 Jul;4(7):559-66.

PMID:
9228949
[PubMed - indexed for MEDLINE]
9.

Two novel sodium channel inhibitors from Heriaeus melloteei spider venom differentially interacting with mammalian channel's isoforms.

Billen B, Vassilevski A, Nikolsky A, Tytgat J, Grishin E.

Toxicon. 2008 Aug 1;52(2):309-17. doi: 10.1016/j.toxicon.2008.05.018. Epub 2008 Jun 7.

PMID:
18606177
[PubMed - indexed for MEDLINE]
10.

Synthesis and characterization of delta-atracotoxin-Ar1a, the lethal neurotoxin from venom of the Sydney funnel-web spider (Atrax robustus).

Alewood D, Birinyi-Strachan LC, Pallaghy PK, Norton RS, Nicholson GM, Alewood PF.

Biochemistry. 2003 Nov 11;42(44):12933-40.

PMID:
14596608
[PubMed - indexed for MEDLINE]
11.

Structure and function of delta-atracotoxins: lethal neurotoxins targeting the voltage-gated sodium channel.

Nicholson GM, Little MJ, Birinyi-Strachan LC.

Toxicon. 2004 Apr;43(5):587-99. Review.

PMID:
15066415
[PubMed - indexed for MEDLINE]
12.

Synthesis, solution structure, and phylum selectivity of a spider delta-toxin that slows inactivation of specific voltage-gated sodium channel subtypes.

Yamaji N, Little MJ, Nishio H, Billen B, Villegas E, Nishiuchi Y, Tytgat J, Nicholson GM, Corzo G.

J Biol Chem. 2009 Sep 4;284(36):24568-82. doi: 10.1074/jbc.M109.030841. Epub 2009 Jul 10.

PMID:
19592486
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel.

Fletcher JI, Chapman BE, Mackay JP, Howden ME, King GF.

Structure. 1997 Nov 15;5(11):1525-35.

PMID:
9384567
[PubMed - indexed for MEDLINE]
14.

Jingzhaotoxin-III, a novel spider toxin inhibiting activation of voltage-gated sodium channel in rat cardiac myocytes.

Xiao Y, Tang J, Yang Y, Wang M, Hu W, Xie J, Zeng X, Liang S.

J Biol Chem. 2004 Jun 18;279(25):26220-6. Epub 2004 Apr 14.

PMID:
15084603
[PubMed - indexed for MEDLINE]
Free Article
15.

Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.

Klint JK, Senff S, Rupasinghe DB, Er SY, Herzig V, Nicholson GM, King GF.

Toxicon. 2012 Sep 15;60(4):478-91. doi: 10.1016/j.toxicon.2012.04.337. Epub 2012 Apr 20. Review.

PMID:
22543187
[PubMed - indexed for MEDLINE]
16.

A novel family of insect-selective peptide neurotoxins targeting insect large-conductance calcium-activated K+ channels isolated from the venom of the theraphosid spider Eucratoscelus constrictus.

Windley MJ, Escoubas P, Valenzuela SM, Nicholson GM.

Mol Pharmacol. 2011 Jul;80(1):1-13. doi: 10.1124/mol.110.070540. Epub 2011 Mar 29.

PMID:
21447641
[PubMed - indexed for MEDLINE]
Free Article
17.

The omega-atracotoxins: selective blockers of insect M-LVA and HVA calcium channels.

Chong Y, Hayes JL, Sollod B, Wen S, Wilson DT, Hains PG, Hodgson WC, Broady KW, King GF, Nicholson GM.

Biochem Pharmacol. 2007 Aug 15;74(4):623-38. Epub 2007 May 25.

PMID:
17610847
[PubMed - indexed for MEDLINE]
18.

Discovery and structure of a potent and highly specific blocker of insect calcium channels.

Wang XH, Connor M, Wilson D, Wilson HI, Nicholson GM, Smith R, Shaw D, Mackay JP, Alewood PF, Christie MJ, King GF.

J Biol Chem. 2001 Oct 26;276(43):40306-12. Epub 2001 Aug 24.

PMID:
11522785
[PubMed - indexed for MEDLINE]
Free Article
19.

Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes.

Bosmans F, Rash L, Zhu S, Diochot S, Lazdunski M, Escoubas P, Tytgat J.

Mol Pharmacol. 2006 Feb;69(2):419-29. Epub 2005 Nov 2.

PMID:
16267209
[PubMed - indexed for MEDLINE]
Free Article
20.

Electrophysiological analysis of the neurotoxic action of a funnel-web spider toxin, delta-atracotoxin-HV1a, on insect voltage-gated Na+ channels.

Grolleau F, Stankiewicz M, Birinyi-Strachan L, Wang XH, Nicholson GM, Pelhate M, Lapied B.

J Exp Biol. 2001 Feb;204(Pt 4):711-21.

PMID:
11171353
[PubMed - indexed for MEDLINE]
Free Article

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