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Results: 1 to 20 of 113

1.

Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models.

Bansal S, Anandatheerthavarada HK, Prabu GK, Milne GL, Martin MV, Guengerich FP, Avadhani NG.

J Biol Chem. 2013 May 3;288(18):12627-44. doi: 10.1074/jbc.M113.452367. Epub 2013 Mar 7.

PMID:
23471973
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes.

Bansal S, Srinivasan S, Anandasadagopan S, Chowdhury AR, Selvaraj V, Kalyanaraman B, Joseph J, Avadhani NG.

J Biol Chem. 2012 May 4;287(19):15284-97. doi: 10.1074/jbc.M111.314062. Epub 2012 Mar 6.

PMID:
22396533
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress.

Bansal S, Liu CP, Sepuri NB, Anandatheerthavarada HK, Selvaraj V, Hoek J, Milne GL, Guengerich FP, Avadhani NG.

J Biol Chem. 2010 Aug 6;285(32):24609-19. doi: 10.1074/jbc.M110.121822. Epub 2010 Jun 7.

PMID:
20529841
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Role of medium-chain triglycerides in the alcohol-mediated cytochrome P450 2E1 induction of mitochondria.

Lieber CS, Cao Q, DeCarli LM, Leo MA, Mak KM, Ponomarenko A, Ren C, Wang X.

Alcohol Clin Exp Res. 2007 Oct;31(10):1660-8. Epub 2007 Aug 6.

PMID:
17681033
[PubMed - indexed for MEDLINE]
5.

Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione.

Bai J, Cederbaum AI.

J Biol Chem. 2006 Feb 24;281(8):5128-36. Epub 2005 Dec 27.

PMID:
16380384
[PubMed - indexed for MEDLINE]
Free Article
6.

Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells.

Otani K, Korenaga M, Beard MR, Li K, Qian T, Showalter LA, Singh AK, Wang T, Weinman SA.

Gastroenterology. 2005 Jan;128(1):96-107.

PMID:
15633127
[PubMed - indexed for MEDLINE]
7.

Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver.

Zhao P, Kalhorn TF, Slattery JT.

Hepatology. 2002 Aug;36(2):326-35.

PMID:
12143040
[PubMed - indexed for MEDLINE]
8.

Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen.

Knockaert L, Descatoire V, Vadrot N, Fromenty B, Robin MA.

Toxicol In Vitro. 2011 Mar;25(2):475-84. doi: 10.1016/j.tiv.2010.11.019. Epub 2010 Dec 2.

PMID:
21130154
[PubMed - indexed for MEDLINE]
9.

Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes.

Robin MA, Sauvage I, Grandperret T, Descatoire V, Pessayre D, Fromenty B.

FEBS Lett. 2005 Dec 19;579(30):6895-902. Epub 2005 Dec 1.

PMID:
16337197
[PubMed - indexed for MEDLINE]
Free Article
10.

Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity.

Knockaert L, Fromenty B, Robin MA.

FEBS J. 2011 Nov;278(22):4252-60. doi: 10.1111/j.1742-4658.2011.08357.x. Epub 2011 Oct 12. Review.

PMID:
21929725
[PubMed - indexed for MEDLINE]
11.

Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae--role of protein kinase A in the mitochondrial targeting of CYP2E1.

Sepuri NB, Yadav S, Anandatheerthavarada HK, Avadhani NG.

FEBS J. 2007 Sep;274(17):4615-30. Epub 2007 Aug 14.

PMID:
17697118
[PubMed - indexed for MEDLINE]
12.

Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo.

Wang X, Wu D, Yang L, Gan L, Cederbaum AI.

Free Radic Biol Med. 2013 Oct;63:175-86. doi: 10.1016/j.freeradbiomed.2013.05.009. Epub 2013 May 10.

PMID:
23669278
[PubMed - indexed for MEDLINE]
13.

Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation.

Robin MA, Anandatheerthavarada HK, Biswas G, Sepuri NB, Gordon DM, Pain D, Avadhani NG.

J Biol Chem. 2002 Oct 25;277(43):40583-93. Epub 2002 Aug 20.

PMID:
12191992
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Alcohol dehydrogenase and cytochrome P450 2E1 can be induced by long-term exposure to ethanol in cultured liver HEP-G2 cells.

Balusikova K, Kovar J.

In Vitro Cell Dev Biol Anim. 2013 Sep;49(8):619-25. doi: 10.1007/s11626-013-9636-y. Epub 2013 Jul 4.

PMID:
23824954
[PubMed - indexed for MEDLINE]
15.

Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction.

Bansal S, Leu AN, Gonzalez FJ, Guengerich FP, Chowdhury AR, Anandatheerthavarada HK, Avadhani NG.

J Biol Chem. 2014 Apr 4;289(14):9936-51. doi: 10.1074/jbc.M113.525659. Epub 2014 Feb 4.

PMID:
24497629
[PubMed - indexed for MEDLINE]
16.

Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1.

Sakurai K, Cederbaum AI.

Mol Pharmacol. 1998 Dec;54(6):1024-35.

PMID:
9855631
[PubMed - indexed for MEDLINE]
Free Article
17.
18.

Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice.

Lu Y, Wu D, Wang X, Ward SC, Cederbaum AI.

Free Radic Biol Med. 2010 Nov 15;49(9):1406-16. doi: 10.1016/j.freeradbiomed.2010.07.026. Epub 2010 Aug 6.

PMID:
20692331
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

In vitro evidence for chronic alcohol and high glucose mediated increased oxidative stress and hepatotoxicity.

Chandrasekaran K, Swaminathan K, Mathan Kumar S, Clemens DL, Dey A.

Alcohol Clin Exp Res. 2012 Jun;36(6):1004-12. doi: 10.1111/j.1530-0277.2011.01697.x. Epub 2012 Feb 6.

PMID:
22309822
[PubMed - indexed for MEDLINE]
20.

Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis.

Chacko BK, Srivastava A, Johnson MS, Benavides GA, Chang MJ, Ye Y, Jhala N, Murphy MP, Kalyanaraman B, Darley-Usmar VM.

Hepatology. 2011 Jul;54(1):153-63. doi: 10.1002/hep.24377.

PMID:
21520201
[PubMed - indexed for MEDLINE]
Free PMC Article

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