Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 99

1.

MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice.

Cogoi S, Zorzet S, Rapozzi V, Géci I, Pedersen EB, Xodo LE.

Nucleic Acids Res. 2013 Apr;41(7):4049-64. doi: 10.1093/nar/gkt127. Epub 2013 Mar 6.

PMID:
23471001
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Protein hnRNPA1 binds to a critical G-rich element of KRAS and unwinds G-quadruplex structures: implications in transcription.

Xodo L, Paramasivam M, Membrino A, Cogoi S.

Nucleic Acids Symp Ser (Oxf). 2008;(52):159-60. doi: 10.1093/nass/nrn081.

PMID:
18776302
[PubMed - indexed for MEDLINE]
Free Article
3.

G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy.

Membrino A, Cogoi S, Pedersen EB, Xodo LE.

PLoS One. 2011;6(9):e24421. doi: 10.1371/journal.pone.0024421. Epub 2011 Sep 8.

PMID:
21931711
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins.

Cogoi S, Paramasivam M, Spolaore B, Xodo LE.

Nucleic Acids Res. 2008 Jun;36(11):3765-80. doi: 10.1093/nar/gkn120. Epub 2008 May 19.

PMID:
18490377
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element.

Cogoi S, Paramasivam M, Membrino A, Yokoyama KK, Xodo LE.

J Biol Chem. 2010 Jul 16;285(29):22003-16. doi: 10.1074/jbc.M110.101923. Epub 2010 May 10.

PMID:
20457603
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells.

Cogoi S, Paramasivam M, Filichev V, Géci I, Pedersen EB, Xodo LE.

J Med Chem. 2009 Jan 22;52(2):564-8. doi: 10.1021/jm800874t.

PMID:
19099510
[PubMed - indexed for MEDLINE]
7.

G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.

Cogoi S, Xodo LE.

Nucleic Acids Res. 2006 May 10;34(9):2536-49. Print 2006.

PMID:
16687659
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription.

Paramasivam M, Membrino A, Cogoi S, Fukuda H, Nakagama H, Xodo LE.

Nucleic Acids Res. 2009 May;37(9):2841-53. doi: 10.1093/nar/gkp138. Epub 2009 Mar 12.

PMID:
19282454
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Purine twisted-intercalating nucleic acids: a new class of anti-gene molecules resistant to potassium-induced aggregation.

Paramasivam M, Cogoi S, Filichev VV, Bomholt N, Pedersen EB, Xodo LE.

Nucleic Acids Res. 2008 Jun;36(10):3494-507. doi: 10.1093/nar/gkn242. Epub 2008 May 2.

PMID:
18456705
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Synergistic effect between erlotinib and MEK inhibitors in KRAS wild-type human pancreatic cancer cells.

Diep CH, Munoz RM, Choudhary A, Von Hoff DD, Han H.

Clin Cancer Res. 2011 May 1;17(9):2744-56. doi: 10.1158/1078-0432.CCR-10-2214. Epub 2011 Mar 8.

PMID:
21385921
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

HRAS is silenced by two neighboring G-quadruplexes and activated by MAZ, a zinc-finger transcription factor with DNA unfolding property.

Cogoi S, Shchekotikhin AE, Xodo LE.

Nucleic Acids Res. 2014;42(13):8379-88. doi: 10.1093/nar/gku574. Epub 2014 Jul 10.

PMID:
25013182
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice.

Mackenzie GG, Bartels LE, Xie G, Papayannis I, Alston N, Vrankova K, Ouyang N, Rigas B.

Neoplasia. 2013 Oct;15(10):1184-95.

PMID:
24204197
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Mutant KRAS is a druggable target for pancreatic cancer.

Zorde Khvalevsky E, Gabai R, Rachmut IH, Horwitz E, Brunschwig Z, Orbach A, Shemi A, Golan T, Domb AJ, Yavin E, Giladi H, Rivkin L, Simerzin A, Eliakim R, Khalaileh A, Hubert A, Lahav M, Kopelman Y, Goldin E, Dancour A, Hants Y, Arbel-Alon S, Abramovitch R, Shemi A, Galun E.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20723-8. doi: 10.1073/pnas.1314307110. Epub 2013 Dec 2.

PMID:
24297898
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

G-rich oligonucleotide inhibits the binding of a nuclear protein to the Ki-ras promoter and strongly reduces cell growth in human carcinoma pancreatic cells.

Cogoi S, Quadrifoglio F, Xodo LE.

Biochemistry. 2004 Mar 9;43(9):2512-23.

PMID:
14992588
[PubMed - indexed for MEDLINE]
15.

The effect of INA [(R)-1-O-(1-pyrenylmethyl)glycerol] insertions on the structure and biological activity of a G-quadruplex from a critical KRAS G-rich sequence.

Cogoi S, Paramasivan M, Xodo LE, Filichev VV, Pedersen EB.

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1641-3.

PMID:
18066843
[PubMed - indexed for MEDLINE]
16.

In vivo serial selection of human pancreatic cancer cells in orthotopic mouse models produces high metastatic variants irrespective of Kras status.

Metildi CA, Kaushal S, Hoffman RM, Bouvet M.

J Surg Res. 2013 Sep;184(1):290-8. doi: 10.1016/j.jss.2013.03.049. Epub 2013 Apr 5.

PMID:
23590868
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer.

Yu S, Lu Z, Liu C, Meng Y, Ma Y, Zhao W, Liu J, Yu J, Chen J.

Cancer Res. 2010 Jul 15;70(14):6015-25. doi: 10.1158/0008-5472.CAN-09-4531. Epub 2010 Jul 7.

PMID:
20610624
[PubMed - indexed for MEDLINE]
Free Article
18.

Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression.

Thakur RK, Kumar P, Halder K, Verma A, Kar A, Parent JL, Basundra R, Kumar A, Chowdhury S.

Nucleic Acids Res. 2009 Jan;37(1):172-83. doi: 10.1093/nar/gkn919. Epub 2008 Nov 25.

PMID:
19033359
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Targeted degradation of KRAS by an engineered ubiquitin ligase suppresses pancreatic cancer cell growth in vitro and in vivo.

Ma Y, Gu Y, Zhang Q, Han Y, Yu S, Lu Z, Chen J.

Mol Cancer Ther. 2013 Mar;12(3):286-94. doi: 10.1158/1535-7163.MCT-12-0650. Epub 2013 Jan 3.

PMID:
23288781
[PubMed - indexed for MEDLINE]
Free Article
20.

The regulatory roles of miRNA and methylation on oncogene and tumor suppressor gene expression in pancreatic cancer cells.

Wang X, Zhao J, Huang J, Tang H, Yu S, Chen Y.

Biochem Biophys Res Commun. 2012 Aug 17;425(1):51-7. doi: 10.1016/j.bbrc.2012.07.047. Epub 2012 Jul 20.

PMID:
22820191
[PubMed - indexed for MEDLINE]
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk