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Results: 1 to 20 of 104

1.

Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii.

Lourido S, Zhang C, Lopez MS, Tang K, Barks J, Wang Q, Wildman SA, Shokat KM, Sibley LD.

J Med Chem. 2013 Apr 11;56(7):3068-77. doi: 10.1021/jm4001314. Epub 2013 Mar 26.

PMID:
23470217
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

A focused small-molecule screen identifies 14 compounds with distinct effects on Toxoplasma gondii.

Kamau ET, Srinivasan AR, Brown MJ, Fair MG, Caraher EJ, Boyle JP.

Antimicrob Agents Chemother. 2012 Nov;56(11):5581-90. doi: 10.1128/AAC.00868-12. Epub 2012 Aug 20.

PMID:
22908155
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.

Johnson SM, Murphy RC, Geiger JA, DeRocher AE, Zhang Z, Ojo KK, Larson ET, Perera BG, Dale EJ, He P, Reid MC, Fox AM, Mueller NR, Merritt EA, Fan E, Parsons M, Van Voorhis WC, Maly DJ.

J Med Chem. 2012 Mar 8;55(5):2416-26. doi: 10.1021/jm201713h. Epub 2012 Feb 27.

PMID:
22320388
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Anticoccidial kinase inhibitors: identification of protein kinase targets secondary to cGMP-dependent protein kinase.

Donald RG, Zhong T, Wiersma H, Nare B, Yao D, Lee A, Allocco J, Liberator PA.

Mol Biochem Parasitol. 2006 Sep;149(1):86-98. Epub 2006 May 23.

PMID:
16765465
[PubMed - indexed for MEDLINE]
5.

Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.

Ojo KK, Larson ET, Keyloun KR, Castaneda LJ, Derocher AE, Inampudi KK, Kim JE, Arakaki TL, Murphy RC, Zhang L, Napuli AJ, Maly DJ, Verlinde CL, Buckner FS, Parsons M, Hol WG, Merritt EA, Van Voorhis WC.

Nat Struct Mol Biol. 2010 May;17(5):602-7. doi: 10.1038/nsmb.1818. Epub 2010 May 2.

PMID:
20436472
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.

Larson ET, Ojo KK, Murphy RC, Johnson SM, Zhang Z, Kim JE, Leibly DJ, Fox AM, Reid MC, Dale EJ, Perera BG, Kim J, Hewitt SN, Hol WG, Verlinde CL, Fan E, Van Voorhis WC, Maly DJ, Merritt EA.

J Med Chem. 2012 Mar 22;55(6):2803-10. doi: 10.1021/jm201725v. Epub 2012 Mar 13.

PMID:
22369268
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Toxoplasma gondii: protective effect of an intranasal SAG1 and MIC4 DNA vaccine in mice.

Wang H, He S, Yao Y, Cong H, Zhao H, Li T, Zhu XQ.

Exp Parasitol. 2009 Jul;122(3):226-32. doi: 10.1016/j.exppara.2009.04.002. Epub 2009 Apr 12.

PMID:
19366622
[PubMed - indexed for MEDLINE]
8.

Evaluation of protective immune responses induced by DNA vaccines encoding Toxoplasma gondii surface antigen 1 (SAG1) and 14-3-3 protein in BALB/c mice.

Meng M, He S, Zhao G, Bai Y, Zhou H, Cong H, Lu G, Zhao Q, Zhu XQ.

Parasit Vectors. 2012 Nov 26;5:273. doi: 10.1186/1756-3305-5-273.

PMID:
23181694
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Protein kinases of Toxoplasma gondii: functions and drug targets.

Wei F, Wang W, Liu Q.

Parasitol Res. 2013 Jun;112(6):2121-9. doi: 10.1007/s00436-013-3451-y. Epub 2013 May 17. Review.

PMID:
23681193
[PubMed - indexed for MEDLINE]
10.

Toxoplasma gondii attachment to host cells is regulated by a calmodulin-like domain protein kinase.

Kieschnick H, Wakefield T, Narducci CA, Beckers C.

J Biol Chem. 2001 Apr 13;276(15):12369-77. Epub 2001 Jan 11.

PMID:
11154702
[PubMed - indexed for MEDLINE]
Free Article
11.

7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities.

Al Safarjalani ON, Rais RH, Kim YA, Chu CK, Naguib FN, el Kouni MH.

Biochem Pharmacol. 2008 Oct 15;76(8):958-66. doi: 10.1016/j.bcp.2008.07.035. Epub 2008 Aug 7.

PMID:
18755159
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Evaluation of a cyclic GMP-dependent protein kinase inhibitor in treatment of murine toxoplasmosis: gamma interferon is required for efficacy.

Nare B, Allocco JJ, Liberator PA, Donald RG.

Antimicrob Agents Chemother. 2002 Feb;46(2):300-7.

PMID:
11796334
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Sensitive and specific detection of toxoplasma DNA in an experimental murine model: use of Toxoplasma gondii-specific cDNA and the polymerase chain reaction.

Weiss LM, Udem SA, Salgo M, Tanowitz HB, Wittner M.

J Infect Dis. 1991 Jan;163(1):180-6.

PMID:
1984466
[PubMed - indexed for MEDLINE]
14.

Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.

Zhang Z, Ojo KK, Johnson SM, Larson ET, He P, Geiger JA, Castellanos-Gonzalez A, White AC Jr, Parsons M, Merritt EA, Maly DJ, Verlinde CL, Van Voorhis WC, Fan E.

Bioorg Med Chem Lett. 2012 Aug 15;22(16):5264-7. doi: 10.1016/j.bmcl.2012.06.050. Epub 2012 Jun 23.

PMID:
22795629
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Rapid discovery of inhibitors of Toxoplasma gondii using hybrid structure-based computational approach.

Kortagere S, Mui E, McLeod R, Welsh WJ.

J Comput Aided Mol Des. 2011 May;25(5):403-11. doi: 10.1007/s10822-011-9420-6. Epub 2011 Feb 26.

PMID:
21359560
[PubMed - indexed for MEDLINE]
16.

Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents.

Gangjee A, Shi J, Queener SF, Barrows LR, Kisliuk RL.

J Med Chem. 1993 Oct 29;36(22):3437-43.

PMID:
8230134
[PubMed - indexed for MEDLINE]
17.

Characterization of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG): antiparasitic activity of a PKG inhibitor.

Diaz CA, Allocco J, Powles MA, Yeung L, Donald RG, Anderson JW, Liberator PA.

Mol Biochem Parasitol. 2006 Mar;146(1):78-88. Epub 2005 Nov 17.

PMID:
16325279
[PubMed - indexed for MEDLINE]
18.

A novel Toxoplasma gondii calcium-dependent protein kinase.

Tzen M, Benarous R, Dupouy-Camet J, Roisin MP.

Parasite. 2007 Jun;14(2):141-7.

PMID:
17645186
[PubMed - indexed for MEDLINE]
19.

Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.

Piper JR, Johnson CA, Krauth CA, Carter RL, Hosmer CA, Queener SF, Borotz SE, Pfefferkorn ER.

J Med Chem. 1996 Mar 15;39(6):1271-80.

PMID:
8632434
[PubMed - indexed for MEDLINE]
20.

Evaluation of immunization with tachyzoite excreted-secreted proteins in a novel susceptible mouse model (A/Sn) for Toxoplasma gondii.

Costa-Silva TA, Meira CS, Ferreira IM, Hiramoto RM, Pereira-Chioccola VL.

Exp Parasitol. 2008 Nov;120(3):227-34. doi: 10.1016/j.exppara.2008.07.015. Epub 2008 Jul 31.

PMID:
18706414
[PubMed - indexed for MEDLINE]

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