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Results: 1 to 20 of 104

1.

Indirubin-3'-monoxime promotes autophagic and apoptotic death in JM1 human acute lymphoblastic leukemia cells and K562 human chronic myelogenous leukemia cells.

Lee MY, Liu YW, Chen MH, Wu JY, Ho HY, Wang QF, Chuang JJ.

Oncol Rep. 2013 May;29(5):2072-8. doi: 10.3892/or.2013.2334. Epub 2013 Mar 6.

PMID:
23468088
[PubMed - indexed for MEDLINE]
2.

Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling.

Nam S, Scuto A, Yang F, Chen W, Park S, Yoo HS, Konig H, Bhatia R, Cheng X, Merz KH, Eisenbrand G, Jove R.

Mol Oncol. 2012 Jun;6(3):276-83. doi: 10.1016/j.molonc.2012.02.002. Epub 2012 Feb 17.

PMID:
22387217
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

An indirubin derivative, indirubin-3'-monoxime suppresses oral cancer tumorigenesis through the downregulation of survivin.

Lo WY, Chang NW.

PLoS One. 2013 Aug 13;8(8):e70198. doi: 10.1371/journal.pone.0070198. eCollection 2013.

PMID:
23967071
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cells.

Shi J, Shen HM.

Biochem Pharmacol. 2008 May 1;75(9):1729-42. doi: 10.1016/j.bcp.2008.01.021. Epub 2008 Mar 10.

PMID:
18377873
[PubMed - indexed for MEDLINE]
5.

Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDA, in chronic myeloid leukemia (K562) cells.

Wu ZZ, Chien CM, Yang SH, Lin YH, Hu XW, Lu YJ, Wu MJ, Lin SR.

Mol Cell Biochem. 2006 Nov;292(1-2):99-105. Epub 2006 May 30.

PMID:
16733797
[PubMed - indexed for MEDLINE]
6.

Induction of apoptosis by apicidin, a histone deacetylase inhibitor, via the activation of mitochondria-dependent caspase cascades in human Bcr-Abl-positive leukemia cells.

Cheong JW, Chong SY, Kim JY, Eom JI, Jeung HK, Maeng HY, Lee ST, Min YH.

Clin Cancer Res. 2003 Oct 15;9(13):5018-27.

PMID:
14581377
[PubMed - indexed for MEDLINE]
Free Article
7.

E1A overcomes the apoptosis block in BCR-ABL+ leukemia cells and renders cells susceptible to induction of apoptosis by chemotherapeutic agents.

Stiewe T, Parssanedjad K, Esche H, Opalka B, Pützer BM.

Cancer Res. 2000 Jul 15;60(14):3957-64.

PMID:
10919674
[PubMed - indexed for MEDLINE]
Free Article
8.

Perifosine induces protective autophagy and upregulation of ATG5 in human chronic myelogenous leukemia cells in vitro.

Tong Y, Liu YY, You LS, Qian WB.

Acta Pharmacol Sin. 2012 Apr;33(4):542-50. doi: 10.1038/aps.2011.192. Epub 2012 Mar 12.

PMID:
22407228
[PubMed - indexed for MEDLINE]
9.

Indirubin-3'-monoxime, a CDK inhibitor induces growth inhibition and apoptosis-independent up-regulation of survivin in transitional cell cancer.

Perabo FG, Frössler C, Landwehrs G, Schmidt DH, von Rücker A, Wirger A, Müller SC.

Anticancer Res. 2006 May-Jun;26(3A):2129-35.

PMID:
16827155
[PubMed - indexed for MEDLINE]
Free Article
10.

Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl.

Mc Gee MM, Campiani G, Ramunno A, Fattorusso C, Nacci V, Lawler M, Williams DC, Zisterer DM.

J Pharmacol Exp Ther. 2001 Jan;296(1):31-40.

PMID:
11123359
[PubMed - indexed for MEDLINE]
Free Article
11.

Indirubin-3'-oxime induces mitochondrial dysfunction and triggers growth inhibition and cell cycle arrest in human neuroblastoma cells.

Liao XM, Leung KN.

Oncol Rep. 2013 Jan;29(1):371-9. doi: 10.3892/or.2012.2094. Epub 2012 Oct 19.

PMID:
23117445
[PubMed - indexed for MEDLINE]
12.

Characteristics of dasatinib- and imatinib-resistant chronic myelogenous leukemia cells.

Okabe S, Tauchi T, Ohyashiki K.

Clin Cancer Res. 2008 Oct 1;14(19):6181-6. doi: 10.1158/1078-0432.CCR-08-0461.

PMID:
18829496
[PubMed - indexed for MEDLINE]
Free Article
13.

Induction of G2/M phase arrest and apoptosis of human leukemia cells by potent antitumor triazoloacridinone C-1305.

Augustin E, Moś-Rompa A, Skwarska A, Witkowski JM, Konopa J.

Biochem Pharmacol. 2006 Dec 15;72(12):1668-79. Epub 2006 Sep 12.

PMID:
16970926
[PubMed - indexed for MEDLINE]
14.

Molecular mechanisms in C-Phycocyanin induced apoptosis in human chronic myeloid leukemia cell line-K562.

Subhashini J, Mahipal SV, Reddy MC, Mallikarjuna Reddy M, Rachamallu A, Reddanna P.

Biochem Pharmacol. 2004 Aug 1;68(3):453-62.

PMID:
15242812
[PubMed - indexed for MEDLINE]
15.

Indirubin-3'-monoxime, a derivative of a chinese antileukemia medicine, inhibits angiogenesis.

Kim JK, Shin EK, Kang YH, Park JH.

J Cell Biochem. 2011 May;112(5):1384-91. doi: 10.1002/jcb.23055.

PMID:
21337385
[PubMed - indexed for MEDLINE]
16.

Indirubin-3'-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK.

Zhen Y, Sørensen V, Jin Y, Suo Z, Wiedłocha A.

Oncogene. 2007 Sep 27;26(44):6372-85. Epub 2007 May 28.

PMID:
17533378
[PubMed - indexed for MEDLINE]
17.

Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo.

Chun-Guang W, Jun-Qing Y, Bei-Zhong L, Dan-Ting J, Chong W, Liang Z, Dan Z, Yan W.

Eur J Pharmacol. 2010 Feb 10;627(1-3):33-41. doi: 10.1016/j.ejphar.2009.10.035. Epub 2009 Oct 24.

PMID:
19857484
[PubMed - indexed for MEDLINE]
18.

Depsipeptide (FK228) preferentially induces apoptosis in BCR/ABL-expressing cell lines and cells from patients with chronic myelogenous leukemia in blast crisis.

Okabe S, Tauchi T, Nakajima A, Sashida G, Gotoh A, Broxmeyer HE, Ohyashiki JH, Ohyashiki K.

Stem Cells Dev. 2007 Jun;16(3):503-14.

PMID:
17610380
[PubMed - indexed for MEDLINE]
19.

Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway.

Kurosu T, Ohki M, Wu N, Kagechika H, Miura O.

Cancer Res. 2009 May 1;69(9):3927-36. doi: 10.1158/0008-5472.CAN-08-2978. Epub 2009 Apr 14.

PMID:
19366808
[PubMed - indexed for MEDLINE]
Free Article
20.

Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway.

Guo Y, Shan Q, Gong Y, Lin J, Yang X, Zhou R.

Cancer Biol Ther. 2012 Nov;13(13):1244-54. doi: 10.4161/cbt.21460. Epub 2012 Aug 16.

PMID:
22895079
[PubMed - indexed for MEDLINE]
Free PMC Article

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