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Results: 1 to 20 of 121

1.

Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells.

Geng R, Sotomayor M, Kinder KJ, Gopal SR, Gerka-Stuyt J, Chen DH, Hardisty-Hughes RE, Ball G, Parker A, Gaudet R, Furness D, Brown SD, Corey DP, Alagramam KN.

J Neurosci. 2013 Mar 6;33(10):4395-404. doi: 10.1523/JNEUROSCI.4514-12.2013.

PMID:
23467356
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Development and regeneration of sensory transduction in auditory hair cells requires functional interaction between cadherin-23 and protocadherin-15.

Lelli A, Kazmierczak P, Kawashima Y, Müller U, Holt JR.

J Neurosci. 2010 Aug 25;30(34):11259-69. doi: 10.1523/JNEUROSCI.1949-10.2010.

PMID:
20739546
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells.

Alagramam KN, Goodyear RJ, Geng R, Furness DN, van Aken AF, Marcotti W, Kros CJ, Richardson GP.

PLoS One. 2011 Apr 21;6(4):e19183. doi: 10.1371/journal.pone.0019183.

PMID:
21532990
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.

Kazmierczak P, Sakaguchi H, Tokita J, Wilson-Kubalek EM, Milligan RA, Müller U, Kachar B.

Nature. 2007 Sep 6;449(7158):87-91.

PMID:
17805295
[PubMed - indexed for MEDLINE]
5.

Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction.

Sotomayor M, Weihofen WA, Gaudet R, Corey DP.

Nature. 2012 Dec 6;492(7427):128-32. doi: 10.1038/nature11590. Epub 2012 Nov 7.

PMID:
23135401
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells.

Indzhykulian AA, Stepanyan R, Nelina A, Spinelli KJ, Ahmed ZM, Belyantseva IA, Friedman TB, Barr-Gillespie PG, Frolenkov GI.

PLoS Biol. 2013;11(6):e1001583. doi: 10.1371/journal.pbio.1001583. Epub 2013 Jun 11.

PMID:
23776407
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain.

Webb SW, Grillet N, Andrade LR, Xiong W, Swarthout L, Della Santina CC, Kachar B, Müller U.

Development. 2011 Apr;138(8):1607-17. doi: 10.1242/dev.060061.

PMID:
21427143
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Tip links in hair cells: molecular composition and role in hearing loss.

Sakaguchi H, Tokita J, Müller U, Kachar B.

Curr Opin Otolaryngol Head Neck Surg. 2009 Oct;17(5):388-93. doi: 10.1097/MOO.0b013e3283303472. Review.

PMID:
19633555
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Cadherins and mechanotransduction by hair cells.

Müller U.

Curr Opin Cell Biol. 2008 Oct;20(5):557-66. doi: 10.1016/j.ceb.2008.06.004. Epub 2008 Jul 30. Review.

PMID:
18619539
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells.

Söllner C, Rauch GJ, Siemens J, Geisler R, Schuster SC, Müller U, Nicolson T; Tübingen 2000 Screen Consortium.

Nature. 2004 Apr 29;428(6986):955-9. Epub 2004 Mar 31.

PMID:
15057246
[PubMed - indexed for MEDLINE]
Free Article
11.

Cadherin 23 is a component of the tip link in hair-cell stereocilia.

Siemens J, Lillo C, Dumont RA, Reynolds A, Williams DS, Gillespie PG, Müller U.

Nature. 2004 Apr 29;428(6986):950-5. Epub 2004 Mar 31.

PMID:
15057245
[PubMed - indexed for MEDLINE]
Free Article
12.

Hair cells, plasma membrane Ca²⁺ ATPase and deafness.

Giacomello M, De Mario A, Primerano S, Brini M, Carafoli E.

Int J Biochem Cell Biol. 2012 May;44(5):679-83. doi: 10.1016/j.biocel.2012.02.006. Epub 2012 Feb 13. Review.

PMID:
22349217
[PubMed - indexed for MEDLINE]
13.

The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene.

Geng R, Melki S, Chen DH, Tian G, Furness DN, Oshima-Takago T, Neef J, Moser T, Askew C, Horwitz G, Holt JR, Imanishi Y, Alagramam KN.

J Neurosci. 2012 Jul 11;32(28):9485-98. doi: 10.1523/JNEUROSCI.0311-12.2012.

PMID:
22787034
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Characterization of a new allele of Ames waltzer generated by ENU mutagenesis.

Washington JL 3rd, Pitts D, Wright CG, Erway LC, Davis RR, Alagramam K.

Hear Res. 2005 Apr;202(1-2):161-9.

PMID:
15811708
[PubMed - indexed for MEDLINE]
15.

Structural determinants of cadherin-23 function in hearing and deafness.

Sotomayor M, Weihofen WA, Gaudet R, Corey DP.

Neuron. 2010 Apr 15;66(1):85-100. doi: 10.1016/j.neuron.2010.03.028.

PMID:
20399731
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells.

Schwander M, Xiong W, Tokita J, Lelli A, Elledge HM, Kazmierczak P, Sczaniecka A, Kolatkar A, Wiltshire T, Kuhn P, Holt JR, Kachar B, Tarantino L, Müller U.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5252-7. doi: 10.1073/pnas.0900691106. Epub 2009 Mar 6.

PMID:
19270079
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Progression of inner ear pathology in Ames waltzer mice and the role of protocadherin 15 in hair cell development.

Pawlowski KS, Kikkawa YS, Wright CG, Alagramam KN.

J Assoc Res Otolaryngol. 2006 Jun;7(2):83-94. Epub 2006 Jan 12.

PMID:
16408167
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15.

Ahmed ZM, Goodyear R, Riazuddin S, Lagziel A, Legan PK, Behra M, Burgess SM, Lilley KS, Wilcox ER, Riazuddin S, Griffith AJ, Frolenkov GI, Belyantseva IA, Richardson GP, Friedman TB.

J Neurosci. 2006 Jun 28;26(26):7022-34.

PMID:
16807332
[PubMed - indexed for MEDLINE]
Free Article
19.

A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth.

Lefèvre G, Michel V, Weil D, Lepelletier L, Bizard E, Wolfrum U, Hardelin JP, Petit C.

Development. 2008 Apr;135(8):1427-37. doi: 10.1242/dev.012922. Epub 2008 Mar 13.

PMID:
18339676
[PubMed - indexed for MEDLINE]
Free Article
20.

A new Atp2b2 deafwaddler allele, dfw(i5), interacts strongly with Cdh23 and other auditory modifiers.

Watson CJ, Tempel BL.

Hear Res. 2013 Oct;304:41-8. doi: 10.1016/j.heares.2013.06.003. Epub 2013 Jun 18.

PMID:
23792079
[PubMed - indexed for MEDLINE]

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