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MADD knock-down enhances doxorubicin and TRAIL induced apoptosis in breast cancer cells.

Turner A, Li LC, Pilli T, Qian L, Wiley EL, Setty S, Christov K, Ganesh L, Maker AV, Li P, Kanteti P, Das Gupta TK, Prabhakar BS.

PLoS One. 2013;8(2):e56817. doi: 10.1371/journal.pone.0056817. Epub 2013 Feb 15.


TRAIL suppresses human breast cancer cell migration via MADD/CXCR7.

Wang R, Li JC.

Asian Pac J Cancer Prev. 2015;16(7):2751-6.


Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4.

Li P, Jayarama S, Ganesh L, Mordi D, Carr R, Kanteti P, Hay N, Prabhakar BS.

J Biol Chem. 2010 Jul 16;285(29):22713-22. doi: 10.1074/jbc.M110.105692. Epub 2010 May 18.


Roscovitine sensitizes breast cancer cells to TRAIL-induced apoptosis through a pleiotropic mechanism.

Ortiz-Ferrón G, Yerbes R, Eramo A, López-Pérez AI, De Maria R, López-Rivas A.

Cell Res. 2008 Jun;18(6):664-76. doi: 10.1038/cr.2008.54.


Knockdown of MADD and c-FLIP overcomes resistance to TRAIL-induced apoptosis in ovarian cancer cells.

Li LC, Jayaram S, Ganesh L, Qian L, Rotmensch J, Maker AV, Prabhakar BS.

Am J Obstet Gynecol. 2011 Oct;205(4):362.e12-25. doi: 10.1016/j.ajog.2011.05.035. Epub 2011 May 27.


MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment.

Kurada BR, Li LC, Mulherkar N, Subramanian M, Prasad KV, Prabhakar BS.

J Biol Chem. 2009 May 15;284(20):13533-41. doi: 10.1074/jbc.M808554200. Epub 2009 Mar 16.


MADD promotes the survival of human lung adenocarcinoma cells by inhibiting apoptosis.

Bi W, Wei Y, Wu J, Sun G, Guo Y, Zhang Q, Dong L.

Oncol Rep. 2013 Apr;29(4):1533-9. doi: 10.3892/or.2013.2258. Epub 2013 Jan 29.


IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC.

Ramaswamy M, Efimova EV, Martinez O, Mulherkar NU, Singh SP, Prabhakar BS.

Oncogene. 2004 Aug 12;23(36):6083-94.


MADD/DENN splice variant of the IG20 gene is necessary and sufficient for cancer cell survival.

Mulherkar N, Ramaswamy M, Mordi DC, Prabhakar BS.

Oncogene. 2006 Oct 12;25(47):6252-61. Epub 2006 May 8.


[Expression of MADD in lung adenocarcinoma tissues and its effects on proliferation and apoptosis of lung adenocarcinoma A549 cells].

Wei YP, Wu JX, Guo YF, Sun GY, Zhang Q, Bi WX, Dong L.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Apr;28(4):354-7. Chinese.


Knockdown of IG20 gene expression renders thyroid cancer cells susceptible to apoptosis.

Subramanian M, Pilli T, Bhattacharya P, Pacini F, Nikiforov YE, Kanteti PV, Prabhakar BS.

J Clin Endocrinol Metab. 2009 Apr;94(4):1467-71. doi: 10.1210/jc.2008-2378. Epub 2009 Feb 3.


Repeated treatment with subtoxic doses of TRAIL induces resistance to apoptosis through its death receptors in MDA-MB-231 breast cancer cells.

Yoshida T, Zhang Y, Rivera Rosado LA, Zhang B.

Mol Cancer Res. 2009 Nov;7(11):1835-44. doi: 10.1158/1541-7786.MCR-09-0244. Epub 2009 Oct 20.


WEE1 inhibition sensitizes basal breast cancer cells to TRAIL-induced apoptosis.

Garimella SV, Rocca A, Lipkowitz S.

Mol Cancer Res. 2012 Jan;10(1):75-85. doi: 10.1158/1541-7786.MCR-11-0500. Epub 2011 Nov 23.


Chemotherapy augments TRAIL-induced apoptosis in breast cell lines.

Keane MM, Ettenberg SA, Nau MM, Russell EK, Lipkowitz S.

Cancer Res. 1999 Feb 1;59(3):734-41.


IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs.

Efimova EV, Al-Zoubi AM, Martinez O, Kaithamana S, Lu S, Arima T, Prabhakar BS.

Oncogene. 2004 Feb 5;23(5):1076-87.


MADD is a downstream target of PTEN in triggering apoptosis.

Jayarama S, Li LC, Ganesh L, Mardi D, Kanteti P, Hay N, Li P, Prabhakar BS.

J Cell Biochem. 2014 Feb;115(2):261-70. doi: 10.1002/jcb.24657.


Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3.

Al-Zoubi AM, Efimova EV, Kaithamana S, Martinez O, El-Idrissi Mel-A, Dogan RE, Prabhakar BS.

J Biol Chem. 2001 Dec 14;276(50):47202-11. Epub 2001 Sep 27.


Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs.

Ganten TM, Haas TL, Sykora J, Stahl H, Sprick MR, Fas SC, Krueger A, Weigand MA, Grosse-Wilde A, Stremmel W, Krammer PH, Walczak H.

Cell Death Differ. 2004 Jul;11 Suppl 1:S86-96.

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