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Results: 1 to 20 of 141

1.

Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer.

Eser S, Reiff N, Messer M, Seidler B, Gottschalk K, Dobler M, Hieber M, Arbeiter A, Klein S, Kong B, Michalski CW, Schlitter AM, Esposito I, Kind AJ, Rad L, Schnieke AE, Baccarini M, Alessi DR, Rad R, Schmid RM, Schneider G, Saur D.

Cancer Cell. 2013 Mar 18;23(3):406-20. doi: 10.1016/j.ccr.2013.01.023. Epub 2013 Feb 28.

PMID:
23453624
[PubMed - indexed for MEDLINE]
Free Article
2.

Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia.

Shi G, DiRenzo D, Qu C, Barney D, Miley D, Konieczny SF.

Oncogene. 2013 Apr 11;32(15):1950-8. doi: 10.1038/onc.2012.210. Epub 2012 Jun 4.

PMID:
22665051
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network.

Ying H, Elpek KG, Vinjamoori A, Zimmerman SM, Chu GC, Yan H, Fletcher-Sananikone E, Zhang H, Liu Y, Wang W, Ren X, Zheng H, Kimmelman AC, Paik JH, Lim C, Perry SR, Jiang S, Malinn B, Protopopov A, Colla S, Xiao Y, Hezel AF, Bardeesy N, Turley SJ, Wang YA, Chin L, Thayer SP, DePinho RA.

Cancer Discov. 2011 Jul;1(2):158-69. doi: 10.1158/2159-8290.CD-11-0031. Epub 2011 May 23.

PMID:
21984975
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Early requirement of Rac1 in a mouse model of pancreatic cancer.

Heid I, Lubeseder-Martellato C, Sipos B, Mazur PK, Lesina M, Schmid RM, Siveke JT.

Gastroenterology. 2011 Aug;141(2):719-30, 730.e1-7. doi: 10.1053/j.gastro.2011.04.043. Epub 2011 Apr 28.

PMID:
21684285
[PubMed - indexed for MEDLINE]
5.

Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues.

Aichler M, Seiler C, Tost M, Siveke J, Mazur PK, Da Silva-Buttkus P, Bartsch DK, Langer P, Chiblak S, Dürr A, Höfler H, Klöppel G, Müller-Decker K, Brielmeier M, Esposito I.

J Pathol. 2012 Apr;226(5):723-34. doi: 10.1002/path.3017. Epub 2012 Jan 17.

PMID:
21984419
[PubMed - indexed for MEDLINE]
6.

Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells.

Ji Z, Mei FC, Xie J, Cheng X.

J Biol Chem. 2007 May 11;282(19):14048-55. Epub 2007 Mar 12.

PMID:
17353198
[PubMed - indexed for MEDLINE]
Free Article
7.

Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo.

Qiu W, Sahin F, Iacobuzio-Donahue CA, Garcia-Carracedo D, Wang WM, Kuo CY, Chen D, Arking DE, Lowy AM, Hruban RH, Remotti HE, Su GH.

Oncotarget. 2011 Nov;2(11):862-73.

PMID:
22113502
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Increase in PI3K signalling mimics mutated-Kras induction of pancreatic cancer.

Baer R, Pyronnet S, Guillermet-Guibert J.

Clin Res Hepatol Gastroenterol. 2013 Sep;37(4):320-1. doi: 10.1016/j.clinre.2013.04.006. Epub 2013 Jun 6. No abstract available.

PMID:
23746401
[PubMed - indexed for MEDLINE]
9.

PTEN loss accelerates KrasG12D-induced pancreatic cancer development.

Hill R, Calvopina JH, Kim C, Wang Y, Dawson DW, Donahue TR, Dry S, Wu H.

Cancer Res. 2010 Sep 15;70(18):7114-24. doi: 10.1158/0008-5472.CAN-10-1649. Epub 2010 Aug 31.

PMID:
20807812
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-β signaling.

Krantz SB, Shields MA, Dangi-Garimella S, Cheon EC, Barron MR, Hwang RF, Rao MS, Grippo PJ, Bentrem DJ, Munshi HG.

Mol Cancer Res. 2011 Oct;9(10):1294-304. doi: 10.1158/1541-7786.MCR-11-0023. Epub 2011 Aug 19.

PMID:
21856775
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Identification and manipulation of biliary metaplasia in pancreatic tumors.

Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, Spence JR, Sipos B, Wright CV, Wells JM, Crawford HC.

Gastroenterology. 2014 Jan;146(1):233-44.e5. doi: 10.1053/j.gastro.2013.08.053. Epub 2013 Aug 30.

PMID:
23999170
[PubMed - indexed for MEDLINE]
12.

LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest.

Morton JP, Jamieson NB, Karim SA, Athineos D, Ridgway RA, Nixon C, McKay CJ, Carter R, Brunton VG, Frame MC, Ashworth A, Oien KA, Evans TR, Sansom OJ.

Gastroenterology. 2010 Aug;139(2):586-97, 597.e1-6. doi: 10.1053/j.gastro.2010.04.055. Epub 2010 May 6.

PMID:
20452353
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.

Ling J, Kang Y, Zhao R, Xia Q, Lee DF, Chang Z, Li J, Peng B, Fleming JB, Wang H, Liu J, Lemischka IR, Hung MC, Chiao PJ.

Cancer Cell. 2012 Jan 17;21(1):105-20. doi: 10.1016/j.ccr.2011.12.006.

PMID:
22264792
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia.

Ray KC, Moss ME, Franklin JL, Weaver CJ, Higginbotham J, Song Y, Revetta FL, Blaine SA, Bridges LR, Guess KE, Coffey RJ, Crawford HC, Washington MK, Means AL.

Oncogene. 2014 Feb 13;33(7):823-31. doi: 10.1038/onc.2013.3. Epub 2013 Feb 4.

PMID:
23376846
[PubMed - indexed for MEDLINE]
15.

The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells.

Xu D, Allsop SA, Witherspoon SM, Snider JL, Yeh JJ, Fiordalisi JJ, White CD, Williams D, Cox AD, Baines AT.

Carcinogenesis. 2011 Apr;32(4):488-95. doi: 10.1093/carcin/bgr007. Epub 2011 Jan 24.

PMID:
21262926
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis.

Rajurkar M, De Jesus-Monge WE, Driscoll DR, Appleman VA, Huang H, Cotton JL, Klimstra DS, Zhu LJ, Simin K, Xu L, McMahon AP, Lewis BC, Mao J.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):E1038-47. doi: 10.1073/pnas.1114168109. Epub 2012 Apr 9.

PMID:
22493246
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression.

Ijichi H, Chytil A, Gorska AE, Aakre ME, Fujitani Y, Fujitani S, Wright CV, Moses HL.

Genes Dev. 2006 Nov 15;20(22):3147-60.

PMID:
17114585
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Phosphorylation at Ser-181 of oncogenic KRAS is required for tumor growth.

Barceló C, Paco N, Morell M, Alvarez-Moya B, Bota-Rabassedas N, Jaumot M, Vilardell F, Capella G, Agell N.

Cancer Res. 2014 Feb 15;74(4):1190-9. doi: 10.1158/0008-5472.CAN-13-1750. Epub 2013 Dec 26.

PMID:
24371225
[PubMed - indexed for MEDLINE]
19.

Efemp1 and p27(Kip1) modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models.

Diersch S, Wenzel P, Szameitat M, Eser P, Paul MC, Seidler B, Eser S, Messer M, Reichert M, Pagel P, Esposito I, Schmid RM, Saur D, Schneider G.

Oncotarget. 2013 Feb;4(2):277-88.

PMID:
23470560
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.

Navas C, Hernández-Porras I, Schuhmacher AJ, Sibilia M, Guerra C, Barbacid M.

Cancer Cell. 2012 Sep 11;22(3):318-30. doi: 10.1016/j.ccr.2012.08.001.

PMID:
22975375
[PubMed - indexed for MEDLINE]
Free PMC Article

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