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Results: 1 to 20 of 82

1.

A series of nonsecosteroidal vitamin D receptor agonists for osteoporosis therapy.

Kashiwagi H, Ono Y, Ohta M, Itoh S, Ichikawa F, Harada S, Takeda S, Sekiguchi N, Ishigai M, Takahashi T.

Bioorg Med Chem. 2013 Apr 1;21(7):1823-33. doi: 10.1016/j.bmc.2013.01.042. Epub 2013 Feb 8.

PMID:
23453218
[PubMed - indexed for MEDLINE]
2.

Novel nonsecosteroidal vitamin D3 carboxylic acid analogs for osteoporosis, and SAR analysis.

Kashiwagi H, Ono Y, Shimizu K, Haneishi T, Ito S, Iijima S, Kobayashi T, Ichikawa F, Harada S, Sato H, Sekiguchi N, Ishigai M, Takahashi T.

Bioorg Med Chem. 2011 Aug 15;19(16):4721-9. doi: 10.1016/j.bmc.2011.07.001. Epub 2011 Jul 8.

PMID:
21795053
[PubMed - indexed for MEDLINE]
3.

A novel nonsecosteroidal VDR agonist (CH5036249) exhibits efficacy in a spontaneous benign prostatic hyperplasia beagle model.

Taniguchi K, Katagiri K, Kashiwagi H, Harada S, Sugimoto Y, Shimizu Y, Arakawa H, Ito T, Yamazaki M, Watanabe T, Kato A, Hoshino E, Takahashi T, Esaki T, Suzuki M, Takeda S, Ichikawa F, Harada A, Sekiguchi N, Ishigai M, Kawata H, Yoneya T, Onuma E, Sudoh M, Aoki Y.

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):204-7. doi: 10.1016/j.jsbmb.2010.03.043. Epub 2010 Mar 18.

PMID:
20304062
[PubMed - indexed for MEDLINE]
4.

A nonsecosteroidal vitamin D receptor ligand with improved therapeutic window of bone efficacy over hypercalcemia.

Sato M, Lu J, Iturria S, Stayrook KR, Burris LL, Zeng QQ, Schmidt A, Barr RJ, Montrose-Rafizadeh C, Bryant HU, Ma YL.

J Bone Miner Res. 2010 Jun;25(6):1326-36. doi: 10.1002/jbmr.15.

PMID:
20200930
[PubMed - indexed for MEDLINE]
5.

Synthesis and biological activities of 14-epi-MART-10 and 14-epi-MART-11: implications for cancer and osteoporosis treatment.

Kittaka A, Hara H, Takano M, Sawada D, Arai MA, Takagi K, Chida T, Harada Y, Saito H, Takenouchi K, Ishizuka S, Hayashi K, Ikushiro S, Sakaki T, Sugiura T, Chen TC.

Anticancer Res. 2009 Sep;29(9):3563-9.

PMID:
19667149
[PubMed - indexed for MEDLINE]
Free Article
6.

Effects of fluorines on nonsecosteroidal vitamin D receptor agonists.

Kashiwagi H, Ohta M, Ono Y, Morikami K, Itoh S, Sato H, Takahashi T.

Bioorg Med Chem. 2013 Feb 1;21(3):712-21. doi: 10.1016/j.bmc.2012.11.029. Epub 2012 Dec 2.

PMID:
23266184
[PubMed - indexed for MEDLINE]
7.

Synthetic studies of vitamin D analogs. XXIV. Synthesis of active vitamin D3 analogs substituted at the 2 beta-position and their preventive effects on bone mineral loss in ovariectomized rats.

Ono Y, Watanabe H, Shiraishi A, Takeda S, Higuchi Y, Sato K, Tsugawa N, Okano T, Kobayashi T, Kubodera N.

Chem Pharm Bull (Tokyo). 1997 Oct;45(10):1626-30.

PMID:
9353890
[PubMed - indexed for MEDLINE]
8.

Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3.

Boehm MF, Fitzgerald P, Zou A, Elgort MG, Bischoff ED, Mere L, Mais DE, Bissonnette RP, Heyman RA, Nadzan AM, Reichman M, Allegretto EA.

Chem Biol. 1999 May;6(5):265-75.

PMID:
10322128
[PubMed - indexed for MEDLINE]
Free Article
9.

Structure-activity relationship of nonsecosteroidal vitamin D receptor modulators.

Yamada S, Makishima M.

Trends Pharmacol Sci. 2014 Jul;35(7):324-37. doi: 10.1016/j.tips.2014.04.008. Epub 2014 May 25. Review.

PMID:
24865943
[PubMed - indexed for MEDLINE]
10.

Systematic SAR study of the side chain of nonsecosteroidal vitamin D₃ analogs.

Kashiwagi H, Ono Y, Ohta M, Morikami K, Takahashi T.

Bioorg Med Chem. 2012 Jul 15;20(14):4495-506. doi: 10.1016/j.bmc.2012.05.023. Epub 2012 May 18.

PMID:
22677528
[PubMed - indexed for MEDLINE]
11.

Vitamin D receptor ligands for osteoporosis.

Cheskis BJ, Freedman LP, Nagpal S.

Curr Opin Investig Drugs. 2006 Oct;7(10):906-11. Review.

PMID:
17086935
[PubMed - indexed for MEDLINE]
12.

Previtamin D3 with a trans-fused decalin CD-ring has pronounced genomic activity.

Verlinden L, Verstuyf A, Verboven C, Eelen G, De Ranter C, Gao LJ, Chen YJ, Murad I, Choi M, Yamamoto K, Yamada S, Van Haver D, Vandewalle M, De Clercq PJ, Bouillon R.

J Biol Chem. 2003 Sep 12;278(37):35476-82. Epub 2003 Jun 26.

PMID:
12829710
[PubMed - indexed for MEDLINE]
Free Article
13.

[Effects of Chinese kidney-tonifying drugs on bone mineral density (BMD), biomechanics, 25-hydroxy vitamin D3 and 1,25-dihydroxy vitamin D3 of ovariectomized osteoporosis rats].

Shuai B, Shen L, Yang YP, Xie J, Zhou PQ, Li H, Guo XF, Zhao J, Wu JL.

Zhongguo Gu Shang. 2008 Nov;21(11):850-3. Chinese.

PMID:
19143251
[PubMed - indexed for MEDLINE]
14.

Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators.

Ma Y, Khalifa B, Yee YK, Lu J, Memezawa A, Savkur RS, Yamamoto Y, Chintalacharuvu SR, Yamaoka K, Stayrook KR, Bramlett KS, Zeng QQ, Chandrasekhar S, Yu XP, Linebarger JH, Iturria SJ, Burris TP, Kato S, Chin WW, Nagpal S.

J Clin Invest. 2006 Apr;116(4):892-904. Epub 2006 Mar 9.

PMID:
16528410
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Differential effects of 1,25-dihydroxyvitamin D3-analogs on osteoblast-like cells and on in vitro bone resorption.

van den Bemd GJ, Pols HA, Birkenhäger JC, Kleinekoort WM, van Leeuwen JP.

J Steroid Biochem Mol Biol. 1995 Dec;55(3-4):337-46.

PMID:
8541230
[PubMed - indexed for MEDLINE]
16.

Potent vitamin D3 analogs: their abilities to enhance transactivation and to bind to the vitamin D3 response element.

Imai Y, Pike JW, Koeffler HP.

Leuk Res. 1995 Mar;19(3):147-58.

PMID:
7700077
[PubMed - indexed for MEDLINE]
17.

20-Cyclopropyl-cholecalciferol vitamin D3 analogs: a unique class of potent inhibitors of proliferation of human prostate, breast and myeloid leukemia cell lines.

Koike M, Koshizuka K, Kawabata H, Yang R, Taub HE, Said J, Uskokovic M, Tsuruoka N, Koeffler HP.

Anticancer Res. 1999 May-Jun;19(3A):1689-97.

PMID:
10470102
[PubMed - indexed for MEDLINE]
18.

Prevention of preneoplastic mammary lesion development by a novel vitamin D analogue, 1alpha-hydroxyvitamin D5.

Mehta RG, Moriarty RM, Mehta RR, Penmasta R, Lazzaro G, Constantinou A, Guo L.

J Natl Cancer Inst. 1997 Feb 5;89(3):212-8.

PMID:
9017001
[PubMed - indexed for MEDLINE]
Free Article
19.

Structure of the ligand-binding domain of rat VDR in complex with the nonsecosteroidal vitamin D3 analogue YR301.

Kakuda S, Okada K, Eguchi H, Takenouchi K, Hakamata W, Kurihara M, Takimoto-Kamimura M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Nov 1;64(Pt 11):970-3. doi: 10.1107/S1744309108026754. Epub 2008 Oct 31.

PMID:
18997319
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

A low-calcemic vitamin D analog (Ro 25-4020) inhibits the growth of LNCaP human prostate cancer cells with increased potency by producing an active 24-oxo metabolite (Ro 29-9970).

Swami S, Zhao XY, Sarabia S, Siu-Caldera ML, Uskokovic M, Reddy SG, Feldman D.

Recent Results Cancer Res. 2003;164:349-52.

PMID:
12899533
[PubMed - indexed for MEDLINE]

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