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Results: 1 to 20 of 113

1.

A new cell culture-based assay quantifies vitamin K 2,3-epoxide reductase complex subunit 1 function and reveals warfarin resistance phenotypes not shown by the dithiothreitol-driven VKOR assay.

Fregin A, Czogalla KJ, Gansler J, Rost S, Taverna M, Watzka M, Bevans CG, Müller CR, Oldenburg J.

J Thromb Haemost. 2013 May;11(5):872-80. doi: 10.1111/jth.12185.

PMID:
23452238
[PubMed - indexed for MEDLINE]
2.

Human VKORC1 mutations cause variable degrees of 4-hydroxycoumarin resistance and affect putative warfarin binding interfaces.

Czogalla KJ, Biswas A, Wendeln AC, Westhofen P, Müller CR, Watzka M, Oldenburg J.

Blood. 2013 Oct 10;122(15):2743-50. doi: 10.1182/blood-2013-05-501692. Epub 2013 Aug 27.

PMID:
23982176
[PubMed - indexed for MEDLINE]
3.

Confirmation of warfarin resistance of naturally occurring VKORC1 variants by coexpression with coagulation factor IX and in silico protein modelling.

Müller E, Keller A, Fregin A, Müller CR, Rost S.

BMC Genet. 2014 Feb 4;15:17. doi: 10.1186/1471-2156-15-17.

PMID:
24491178
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Determination of the warfarin inhibition constant Ki for vitamin K 2,3-epoxide reductase complex subunit-1 (VKORC1) using an in vitro DTT-driven assay.

Bevans CG, Krettler C, Reinhart C, Tran H, Koßmann K, Watzka M, Oldenburg J.

Biochim Biophys Acta. 2013 Aug;1830(8):4202-10. doi: 10.1016/j.bbagen.2013.04.018. Epub 2013 Apr 22.

PMID:
23618698
[PubMed - indexed for MEDLINE]
Free Article
5.

Evaluation of warfarin resistance using transcription activator-like effector nucleases-mediated vitamin K epoxide reductase knockout HEK293 cells.

Tie JK, Jin DY, Tie K, Stafford DW.

J Thromb Haemost. 2013 Aug;11(8):1556-64. doi: 10.1111/jth.12306.

PMID:
23710884
[PubMed - indexed for MEDLINE]
6.

VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.

Hammed A, Matagrin B, Spohn G, Prouillac C, Benoit E, Lattard V.

J Biol Chem. 2013 Oct 4;288(40):28733-42. doi: 10.1074/jbc.M113.457119. Epub 2013 Aug 8.

PMID:
23928358
[PubMed - indexed for MEDLINE]
7.

The vitamin K oxidoreductase is a multimer that efficiently reduces vitamin K epoxide to hydroquinone to allow vitamin K-dependent protein carboxylation.

Rishavy MA, Hallgren KW, Wilson LA, Usubalieva A, Runge KW, Berkner KL.

J Biol Chem. 2013 Nov 1;288(44):31556-66. doi: 10.1074/jbc.M113.497297. Epub 2013 Aug 5.

PMID:
23918929
[PubMed - indexed for MEDLINE]
8.

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.

Rost S, Fregin A, Ivaskevicius V, Conzelmann E, Hörtnagel K, Pelz HJ, Lappegard K, Seifried E, Scharrer I, Tuddenham EG, Müller CR, Strom TM, Oldenburg J.

Nature. 2004 Feb 5;427(6974):537-41.

PMID:
14765194
[PubMed - indexed for MEDLINE]
9.

Warfarin resistance in a French strain of rats.

Lasseur R, Longin-Sauvageon C, Videmann B, Billeret M, Berny P, Benoit E.

J Biochem Mol Toxicol. 2005;19(6):379-85.

PMID:
16421894
[PubMed - indexed for MEDLINE]
10.

Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1.

Harrington DJ, Underwood S, Morse C, Shearer MJ, Tuddenham EG, Mumford AD.

Thromb Haemost. 2005 Jan;93(1):23-6.

PMID:
15630486
[PubMed - indexed for MEDLINE]
11.

A vitamin K epoxide reductase complex subunit 1 mutation in an Irish patient with warfarin resistance.

Ainle FN, Mumford A, Tallon E, McCarthy D, Murphy K.

Ir J Med Sci. 2008 Jun;177(2):159-61. doi: 10.1007/s11845-008-0126-2. Epub 2008 Feb 12.

PMID:
18266023
[PubMed - indexed for MEDLINE]
12.

A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats.

Tanaka KD, Kawai YK, Ikenaka Y, Harunari T, Tanikawa T, Fujita S, Ishizuka M.

J Vet Med Sci. 2013 Feb;75(2):135-9. Epub 2012 Sep 26.

PMID:
23018795
[PubMed - indexed for MEDLINE]
Free Article
13.

Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin.

Rost S, Fregin A, Hünerberg M, Bevans CG, Müller CR, Oldenburg J.

Thromb Haemost. 2005 Oct;94(4):780-6.

PMID:
16270630
[PubMed - indexed for MEDLINE]
14.

Pesticide resistance in wild mammals--mechanisms of anticoagulant resistance in wild rodents.

Ishizuka M, Tanikawa T, Tanaka KD, Heewon M, Okajima F, Sakamoto KQ, Fujita S.

J Toxicol Sci. 2008 Aug;33(3):283-91.

PMID:
18670159
[PubMed - indexed for MEDLINE]
Free Article
15.

Vitamin K epoxide reductase complex 1 (VKORC1) gene polymorphisms in population of Eastern Croatia.

Mandić D, Mandić S, Horvat V, Samardzija M, Samardzija M.

Coll Antropol. 2013 Dec;37(4):1321-6.

PMID:
24611351
[PubMed - indexed for MEDLINE]
16.

Warfarin resistance is associated with a protein component of the vitamin K 2,3-epoxide reductase enzyme complex in rat liver.

Cain D, Hutson SM, Wallin R.

Thromb Haemost. 1998 Jul;80(1):128-33.

PMID:
9684798
[PubMed - indexed for MEDLINE]
17.

A cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites.

Haque JA, McDonald MG, Kulman JD, Rettie AE.

Blood. 2014 Jan 23;123(4):582-9. doi: 10.1182/blood-2013-05-505123. Epub 2013 Dec 2.

PMID:
24297869
[PubMed - indexed for MEDLINE]
18.

Novel mutations in the VKORC1 gene of wild rats and mice--a response to 50 years of selection pressure by warfarin?

Rost S, Pelz HJ, Menzel S, MacNicoll AD, León V, Song KJ, Jäkel T, Oldenburg J, Müller CR.

BMC Genet. 2009 Feb 6;10:4. doi: 10.1186/1471-2156-10-4.

PMID:
19200363
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in-vivo investigation in a 7th generation of congenic Y139F strain of rats.

Grandemange A, Kohn MH, Lasseur R, Longin-Sauvageon C, Berny P, Benoit E.

Pharmacogenet Genomics. 2009 Oct;19(10):742-50. doi: 10.1097/FPC.0b013e32832ee55b.

PMID:
19752778
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Comparative genetics of warfarin resistance.

Oldenburg J, Müller CR, Rost S, Watzka M, Bevans CG.

Hamostaseologie. 2014;34(2):143-59. doi: 10.5482/HAMO-13-09-0047. Epub 2013 Nov 29.

PMID:
24287886
[PubMed - in process]

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