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Results: 1 to 20 of 107

Similar articles for PubMed (Select 23448584)

1.

Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors.

Gampe CM, Tsukamoto H, Doud EH, Walker S, Kahne D.

J Am Chem Soc. 2013 Mar 13;135(10):3776-9. doi: 10.1021/ja4000933. Epub 2013 Mar 4.

2.

A new antibiotic kills pathogens without detectable resistance.

Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K.

Nature. 2015 Jan 22;517(7535):455-9. doi: 10.1038/nature14098. Epub 2015 Jan 7. Erratum in: Nature. 2015 Apr 16;520(7547):388.

PMID:
25561178
3.

Positive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase.

Bury D, Dahmane I, Derouaux A, Dumbre S, Herdewijn P, Matagne A, Breukink E, Mueller-Seitz E, Petz M, Terrak M.

Biochem Pharmacol. 2015 Jan 15;93(2):141-50. doi: 10.1016/j.bcp.2014.11.003. Epub 2014 Nov 14.

PMID:
25462814
4.

Prospects for novel inhibitors of peptidoglycan transglycosylases.

Galley NF, O'Reilly AM, Roper DI.

Bioorg Chem. 2014 Aug;55:16-26. doi: 10.1016/j.bioorg.2014.05.007. Epub 2014 May 21.

5.

Structure-based design, synthesis, and biological evaluation of isatin derivatives as potential glycosyltransferase inhibitors.

Wang Y, Chan FY, Sun N, Lui HK, So PK, Yan SC, Chan KF, Chiou J, Chen S, Abagyan R, Leung YC, Wong KY.

Chem Biol Drug Des. 2014 Dec;84(6):685-96. doi: 10.1111/cbdd.12361. Epub 2014 Aug 14.

PMID:
24890564
6.

Moenomycin resistance mutations in Staphylococcus aureus reduce peptidoglycan chain length and cause aberrant cell division.

Rebets Y, Lupoli T, Qiao Y, Schirner K, Villet R, Hooper D, Kahne D, Walker S.

ACS Chem Biol. 2014 Feb 21;9(2):459-67. doi: 10.1021/cb4006744. Epub 2013 Nov 20.

7.

MoeH5: a natural glycorandomizer from the moenomycin biosynthetic pathway.

Ostash B, Campbell J, Luzhetskyy A, Walker S.

Mol Microbiol. 2013 Dec;90(6):1324-38. doi: 10.1111/mmi.12437. Epub 2013 Nov 21.

8.

New continuous fluorometric assay for bacterial transglycosylase using Förster resonance energy transfer.

Huang SH, Wu WS, Huang LY, Huang WF, Fu WC, Chen PT, Fang JM, Cheng WC, Cheng TJ, Wong CH.

J Am Chem Soc. 2013 Nov 13;135(45):17078-89. doi: 10.1021/ja407985m. Epub 2013 Nov 5.

PMID:
24131464
9.

Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme MurG.

Mann PA, Müller A, Xiao L, Pereira PM, Yang C, Ho Lee S, Wang H, Trzeciak J, Schneeweis J, Dos Santos MM, Murgolo N, She X, Gill C, Balibar CJ, Labroli M, Su J, Flattery A, Sherborne B, Maier R, Tan CM, Black T, Onder K, Kargman S, Monsma FJ Jr, Pinho MG, Schneider T, Roemer T.

ACS Chem Biol. 2013 Nov 15;8(11):2442-51. doi: 10.1021/cb400487f. Epub 2013 Sep 5.

PMID:
23957438
10.

In silico optimization of a fragment-based hit yields biologically active, high-efficiency inhibitors for glutamate racemase.

Whalen KL, Chau AC, Spies MA.

ChemMedChem. 2013 Oct;8(10):1681-9. doi: 10.1002/cmdc.201300271. Epub 2013 Aug 8.

11.

Direction of aminoacylated transfer RNAs into antibiotic synthesis and peptidoglycan-mediated antibiotic resistance.

Shepherd J, Ibba M.

FEBS Lett. 2013 Sep 17;587(18):2895-904. doi: 10.1016/j.febslet.2013.07.036. Epub 2013 Jul 29. Review.

12.

Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular synthesis assay.

Cunningham ML, Kwan BP, Nelson KJ, Bensen DC, Shaw KJ.

J Biomol Screen. 2013 Oct;18(9):1018-26. doi: 10.1177/1087057113487208. Epub 2013 May 17.

PMID:
23686103
13.

New structural scaffold 14-membered macrocyclic lactone ring for selective inhibitors of cell wall peptidoglycan biosynthesis in Staphylococcus aureus.

Koyama N, Yotsumoto M, Onaka H, Tomoda H.

J Antibiot (Tokyo). 2013 May;66(5):303-4. doi: 10.1038/ja.2012.122. Epub 2013 Jan 23. No abstract available.

PMID:
23340661
14.

Anti-infectious agents against MRSA.

Koyama N, Inokoshi J, Tomoda H.

Molecules. 2012 Dec 24;18(1):204-24. doi: 10.3390/molecules18010204. Review.

15.

Antibacterial drug leads targeting isoprenoid biosynthesis.

Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, Nizet V, McCammon JA, Oldfield E.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):123-8. doi: 10.1073/pnas.1219899110. Epub 2012 Dec 17.

16.

Screen for agents that induce autolysis in Bacillus subtilis.

Lacriola CJ, Falk SP, Weisblum B.

Antimicrob Agents Chemother. 2013 Jan;57(1):229-34. doi: 10.1128/AAC.00741-12. Epub 2012 Oct 22.

17.

Inhibitors targeting on cell wall biosynthesis pathway of MRSA.

Hao H, Cheng G, Dai M, Wu Q, Yuan Z.

Mol Biosyst. 2012 Nov;8(11):2828-38. doi: 10.1039/c2mb25188d. Epub 2012 Aug 16. Review.

PMID:
22898792
18.

Cell wall active antibiotics reduce chromosomal DNA fragmentation by peptidoglycan hydrolysis in Staphylococcus aureus.

Tamayo M, Santiso R, Gosálvez J, Bou G, Fernández Mdel C, Fernández JL.

Arch Microbiol. 2012 Dec;194(12):967-75. doi: 10.1007/s00203-012-0831-0. Epub 2012 Jul 15.

PMID:
22797526
19.

Synthesis of modified peptidoglycan precursor analogues for the inhibition of glycosyltransferase.

Dumbre S, Derouaux A, Lescrinier E, Piette A, Joris B, Terrak M, Herdewijn P.

J Am Chem Soc. 2012 Jun 6;134(22):9343-51. doi: 10.1021/ja302099u. Epub 2012 May 25.

PMID:
22550974
20.
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