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Results: 1 to 20 of 100

1.

Arylazanylpyrazolone derivatives as inhibitors of mutant superoxide dismutase 1 dependent protein aggregation for the treatment of amyotrophic lateral sclerosis.

Zhang Y, Benmohamed R, Huang H, Chen T, Voisine C, Morimoto RI, Kirsch DR, Silverman RB.

J Med Chem. 2013 Mar 28;56(6):2665-75. doi: 10.1021/jm400079a. Epub 2013 Mar 15.

PMID:
23445362
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis.

Chen T, Benmohamed R, Kim J, Smith K, Amante D, Morimoto RI, Kirsch DR, Ferrante RJ, Silverman RB.

J Med Chem. 2012 Jan 12;55(1):515-27. doi: 10.1021/jm2014277. Epub 2011 Dec 22.

PMID:
22191331
[PubMed - indexed for MEDLINE]
3.

Substituted pyrazolones require N2 hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1.

Trippier PC, Benmohamed R, Kirsch DR, Silverman RB.

Bioorg Med Chem Lett. 2012 Nov 1;22(21):6647-50. doi: 10.1016/j.bmcl.2012.08.114. Epub 2012 Sep 7. Erratum in: Bioorg Med Chem Lett. 2014 Jan 15;24(2):691. Benmohammed, Radhia [corrected to Benmohamed, Radhia].

PMID:
23021992
[PubMed - indexed for MEDLINE]
4.

Pyrimidine-2,4,6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis.

Xia G, Benmohamed R, Kim J, Arvanites AC, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB.

J Med Chem. 2011 Apr 14;54(7):2409-21. doi: 10.1021/jm101549k. Epub 2011 Mar 4.

PMID:
21375347
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis.

Chen T, Benmohamed R, Arvanites AC, Ralay Ranaivo H, Morimoto RI, Ferrante RJ, Watterson DM, Kirsch DR, Silverman RB.

Bioorg Med Chem. 2011 Jan 1;19(1):613-22. doi: 10.1016/j.bmc.2010.10.052. Epub 2010 Oct 30.

PMID:
21095130
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Structural instability and Cu-dependent pro-oxidant activity acquired by the apo form of mutant SOD1 associated with amyotrophic lateral sclerosis.

Kitamura F, Fujimaki N, Okita W, Hiramatsu H, Takeuchi H.

Biochemistry. 2011 May 24;50(20):4242-50. doi: 10.1021/bi200338h. Epub 2011 May 2.

PMID:
21506602
[PubMed - indexed for MEDLINE]
7.

Structural changes to monomeric CuZn superoxide dismutase caused by the familial amyotrophic lateral sclerosis-associated mutation A4V.

Schmidlin T, Kennedy BK, Daggett V.

Biophys J. 2009 Sep 16;97(6):1709-18. doi: 10.1016/j.bpj.2009.06.043.

PMID:
19751676
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Cyclohexane 1,3-diones and their inhibition of mutant SOD1-dependent protein aggregation and toxicity in PC12 cells.

Zhang W, Benmohamed R, Arvanites AC, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB.

Bioorg Med Chem. 2012 Jan 15;20(2):1029-45. doi: 10.1016/j.bmc.2011.11.039. Epub 2011 Nov 30.

PMID:
22189273
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis.

Facchinetti F, Sasaki M, Cutting FB, Zhai P, MacDonald JE, Reif D, Beal MF, Huang PL, Dawson TM, Gurney ME, Dawson VL.

Neuroscience. 1999;90(4):1483-92.

PMID:
10338314
[PubMed - indexed for MEDLINE]
10.

Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis.

Auclair JR, Boggio KJ, Petsko GA, Ringe D, Agar JN.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21394-9. doi: 10.1073/pnas.1015463107. Epub 2010 Nov 22.

PMID:
21098299
[PubMed - indexed for MEDLINE]
Free PMC Article
11.
12.

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide.

Yim MB, Kang JH, Yim HS, Kwak HS, Chock PB, Stadtman ER.

Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5709-14.

PMID:
8650157
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Ligand binding and aggregation of pathogenic SOD1.

Wright GS, Antonyuk SV, Kershaw NM, Strange RW, Samar Hasnain S.

Nat Commun. 2013;4:1758. doi: 10.1038/ncomms2750.

PMID:
23612299
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation.

Kimata A, Nakagawa H, Ohyama R, Fukuuchi T, Ohta S, Doh-ura K, Suzuki T, Miyata N.

J Med Chem. 2007 Oct 18;50(21):5053-6. Epub 2007 Sep 13. Erratum in: J Med Chem. 2008 Mar 13;51(5):1503.

PMID:
17850126
[PubMed - indexed for MEDLINE]
15.

Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-superoxide dismutase induces toxicity independent of protein aggregation.

Witan H, Kern A, Koziollek-Drechsler I, Wade R, Behl C, Clement AM.

Hum Mol Genet. 2008 May 15;17(10):1373-85. doi: 10.1093/hmg/ddn025. Epub 2008 Jan 22.

PMID:
18211954
[PubMed - indexed for MEDLINE]
Free Article
16.

Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis.

Walker AK, Farg MA, Bye CR, McLean CA, Horne MK, Atkin JD.

Brain. 2010 Jan;133(Pt 1):105-16. doi: 10.1093/brain/awp267. Epub 2009 Nov 10.

PMID:
19903735
[PubMed - indexed for MEDLINE]
Free Article
17.

Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis.

Furukawa Y, Kaneko K, Watanabe S, Yamanaka K, Nukina N.

FEBS Lett. 2013 Aug 19;587(16):2500-5. doi: 10.1016/j.febslet.2013.06.046. Epub 2013 Jul 4.

PMID:
23831581
[PubMed - indexed for MEDLINE]
18.

Protein aggregation and protein instability govern familial amyotrophic lateral sclerosis patient survival.

Wang Q, Johnson JL, Agar NY, Agar JN.

PLoS Biol. 2008 Jul 29;6(7):e170. doi: 10.1371/journal.pbio.0060170.

PMID:
18666828
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Wild-type Cu/Zn superoxide dismutase (SOD1) does not facilitate, but impedes the formation of protein aggregates of amyotrophic lateral sclerosis causing mutant SOD1.

Witan H, Gorlovoy P, Kaya AM, Koziollek-Drechsler I, Neumann H, Behl C, Clement AM.

Neurobiol Dis. 2009 Nov;36(2):331-42. doi: 10.1016/j.nbd.2009.07.024. Epub 2009 Aug 4.

PMID:
19660548
[PubMed - indexed for MEDLINE]
20.

Cu/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress.

Cookson MR, Menzies FM, Manning P, Eggett CJ, Figlewicz DA, McNeil CJ, Shaw PJ.

Amyotroph Lateral Scler Other Motor Neuron Disord. 2002 Jun;3(2):75-85.

PMID:
12215229
[PubMed - indexed for MEDLINE]

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