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Items: 1 to 20 of 134


Defining the membrane-associated state of the PTEN tumor suppressor protein.

Lumb CN, Sansom MS.

Biophys J. 2013 Feb 5;104(3):613-21. doi: 10.1016/j.bpj.2012.12.002.


Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate.

Campbell RB, Liu F, Ross AH.

J Biol Chem. 2003 Sep 5;278(36):33617-20. Epub 2003 Jul 11.


PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes.

Redfern RE, Redfern D, Furgason ML, Munson M, Ross AH, Gericke A.

Biochemistry. 2008 Feb 19;47(7):2162-71. doi: 10.1021/bi702114w. Epub 2008 Jan 26.


Membrane association of the PTEN tumor suppressor: electrostatic interaction with phosphatidylserine-containing bilayers and regulatory role of the C-terminal tail.

Shenoy SS, Nanda H, Lösche M.

J Struct Biol. 2012 Dec;180(3):394-408. doi: 10.1016/j.jsb.2012.10.003. Epub 2012 Oct 13.


Interactions of the auxilin-1 PTEN-like domain with model membranes result in nanoclustering of phosphatidyl inositol phosphates.

Kalli AC, Morgan G, Sansom MS.

Biophys J. 2013 Jul 2;105(1):137-45. doi: 10.1016/j.bpj.2013.05.012.


A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate.

Iwasaki H, Murata Y, Kim Y, Hossain MI, Worby CA, Dixon JE, McCormack T, Sasaki T, Okamura Y.

Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):7970-5. doi: 10.1073/pnas.0803936105. Epub 2008 Jun 4.


A mutant form of PTEN linked to autism.

Redfern RE, Daou MC, Li L, Munson M, Gericke A, Ross AH.

Protein Sci. 2010 Oct;19(10):1948-56. doi: 10.1002/pro.483.


Membrane association of the PTEN tumor suppressor: molecular details of the protein-membrane complex from SPR binding studies and neutron reflection.

Shenoy S, Shekhar P, Heinrich F, Daou MC, Gericke A, Ross AH, Lösche M.

PLoS One. 2012;7(4):e32591. doi: 10.1371/journal.pone.0032591. Epub 2012 Apr 10.


Finding a needle in a haystack: the role of electrostatics in target lipid recognition by PH domains.

Lumb CN, Sansom MS.

PLoS Comput Biol. 2012;8(7):e1002617. doi: 10.1371/journal.pcbi.1002617. Epub 2012 Jul 26.


PTEN hopping on the cell membrane is regulated via a positively-charged C2 domain.

Yasui M, Matsuoka S, Ueda M.

PLoS Comput Biol. 2014 Sep 11;10(9):e1003817. doi: 10.1371/journal.pcbi.1003817. eCollection 2014 Sep.


Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species.

Downes CP, Walker S, McConnachie G, Lindsay Y, Batty IH, Leslie NR.

Biochem Soc Trans. 2004 Apr;32(Pt 2):338-42. Review.


Crystal structure of the cytoplasmic phosphatase and tensin homolog (PTEN)-like region of Ciona intestinalis voltage-sensing phosphatase provides insight into substrate specificity and redox regulation of the phosphoinositide phosphatase activity.

Matsuda M, Takeshita K, Kurokawa T, Sakata S, Suzuki M, Yamashita E, Okamura Y, Nakagawa A.

J Biol Chem. 2011 Jul 1;286(26):23368-77. doi: 10.1074/jbc.M110.214361. Epub 2011 May 4.


Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor.

Georgescu MM, Kirsch KH, Kaloudis P, Yang H, Pavletich NP, Hanafusa H.

Cancer Res. 2000 Dec 15;60(24):7033-8.


The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif.

Walker SM, Leslie NR, Perera NM, Batty IH, Downes CP.

Biochem J. 2004 Apr 15;379(Pt 2):301-7.


PtdIns(4,5)P2-mediated cell signaling: emerging principles and PTEN as a paradigm for regulatory mechanism.

Gericke A, Leslie NR, Lösche M, Ross AH.

Adv Exp Med Biol. 2013;991:85-104. doi: 10.1007/978-94-007-6331-9_6. Review.


Membrane association of the PTEN tumor suppressor: neutron scattering and MD simulations reveal the structure of protein-membrane complexes.

Nanda H, Heinrich F, Lösche M.

Methods. 2015 May;77-78:136-46. doi: 10.1016/j.ymeth.2014.10.014. Epub 2014 Oct 27. Review.


Biophysical methods for the characterization of PTEN/lipid bilayer interactions.

Harishchandra RK, Neumann BM, Gericke A, Ross AH.

Methods. 2015 May;77-78:125-35. doi: 10.1016/j.ymeth.2015.02.004. Epub 2015 Feb 16. Review.


Phospholipid-binding sites of phosphatase and tensin homolog (PTEN): exploring the mechanism of phosphatidylinositol 4,5-bisphosphate activation.

Wei Y, Stec B, Redfield AG, Weerapana E, Roberts MF.

J Biol Chem. 2015 Jan 16;290(3):1592-606. doi: 10.1074/jbc.M114.588590. Epub 2014 Nov 27.

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