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Results: 1 to 20 of 115

1.

Enhanced effectivity of an ALK5-inhibitor after cell-specific delivery to hepatic stellate cells in mice with liver injury.

van Beuge MM, Prakash J, Lacombe M, Post E, Reker-Smit C, Beljaars L, Poelstra K.

PLoS One. 2013;8(2):e56442. doi: 10.1371/journal.pone.0056442. Epub 2013 Feb 18.

PMID:
23441194
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Increased liver uptake and reduced hepatic stellate cell activation with a cell-specific conjugate of the Rho-kinase inhibitor Y27632.

van Beuge MM, Prakash J, Lacombe M, Post E, Reker-Smit C, Beljaars L, Poelstra K.

Pharm Res. 2011 Aug;28(8):2045-54. doi: 10.1007/s11095-011-0430-9. Epub 2011 Mar 26.

PMID:
21442374
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis.

de Gouville AC, Boullay V, Krysa G, Pilot J, Brusq JM, Loriolle F, Gauthier JM, Papworth SA, Laroze A, Gellibert F, Huet S.

Br J Pharmacol. 2005 May;145(2):166-77.

PMID:
15723089
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Reduction of fibrogenesis by selective delivery of a Rho kinase inhibitor to hepatic stellate cells in mice.

van Beuge MM, Prakash J, Lacombe M, Gosens R, Post E, Reker-Smit C, Beljaars L, Poelstra K.

J Pharmacol Exp Ther. 2011 Jun;337(3):628-35. doi: 10.1124/jpet.111.179143. Epub 2011 Mar 7.

PMID:
21383021
[PubMed - indexed for MEDLINE]
Free Article
5.

Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes.

Weng HL, Ciuclan L, Liu Y, Hamzavi J, Godoy P, Gaitantzi H, Kanzler S, Heuchel R, Ueberham U, Gebhardt R, Breitkopf K, Dooley S.

Hepatology. 2007 Oct;46(4):1257-70.

PMID:
17657819
[PubMed - indexed for MEDLINE]
6.

Inhibition of ALK5 as a new approach to treat liver fibrotic diseases.

de Gouville AC, Huet S.

Drug News Perspect. 2006 Mar;19(2):85-90. Review.

PMID:
16628263
[PubMed - indexed for MEDLINE]
7.

Peptide-modified albumin carrier explored as a novel strategy for a cell-specific delivery of interferon gamma to treat liver fibrosis.

Bansal R, Prakash J, de Ruijter M, Beljaars L, Poelstra K.

Mol Pharm. 2011 Oct 3;8(5):1899-909. doi: 10.1021/mp200263q. Epub 2011 Aug 8.

PMID:
21800888
[PubMed - indexed for MEDLINE]
8.

Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis.

Prakash J, de Borst MH, van Loenen-Weemaes AM, Lacombe M, Opdam F, van Goor H, Meijer DK, Moolenaar F, Poelstra K, Kok RJ.

Pharm Res. 2008 Oct;25(10):2427-39. doi: 10.1007/s11095-007-9515-x. Epub 2008 Jan 9.

PMID:
18183478
[PubMed - indexed for MEDLINE]
9.

Fibronectin protects from excessive liver fibrosis by modulating the availability of and responsiveness of stellate cells to active TGF-β.

Kawelke N, Vasel M, Sens C, Au Av, Dooley S, Nakchbandi IA.

PLoS One. 2011;6(11):e28181. doi: 10.1371/journal.pone.0028181. Epub 2011 Nov 28.

PMID:
22140539
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Cooperation of liver cells in health and disease.

Kmieć Z.

Adv Anat Embryol Cell Biol. 2001;161:III-XIII, 1-151. Review.

PMID:
11729749
[PubMed - indexed for MEDLINE]
11.

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo.

Jiang JX, Chen X, Serizawa N, Szyndralewiez C, Page P, Schröder K, Brandes RP, Devaraj S, Török NJ.

Free Radic Biol Med. 2012 Jul 15;53(2):289-96. doi: 10.1016/j.freeradbiomed.2012.05.007. Epub 2012 May 19.

PMID:
22618020
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis.

Lakner AM, Steuerwald NM, Walling TL, Ghosh S, Li T, McKillop IH, Russo MW, Bonkovsky HL, Schrum LW.

Hepatology. 2012 Jul;56(1):300-10. doi: 10.1002/hep.25613. Epub 2012 Jun 18.

PMID:
22278637
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

HGF regulates the activation of TGF-β1 in rat hepatocytes and hepatic stellate cells.

Narmada BC, Chia SM, Tucker-Kellogg L, Yu H.

J Cell Physiol. 2013 Feb;228(2):393-401. doi: 10.1002/jcp.24143.

PMID:
22718393
[PubMed - indexed for MEDLINE]
14.

Adenoviral delivery of dominant-negative transforming growth factor beta type II receptor up-regulates transcriptional repressor SKI-like oncogene, decreases matrix metalloproteinase 2 in hepatic stellate cell and prevents liver fibrosis in rats.

Marquez-Aguirre A, Sandoval-Rodriguez A, Gonzalez-Cuevas J, Bueno-Topete M, Navarro-Partida J, Arellano-Olivera I, Lucano-Landeros S, Armendariz-Borunda J.

J Gene Med. 2009 Mar;11(3):207-19. doi: 10.1002/jgm.1303.

PMID:
19189315
[PubMed - indexed for MEDLINE]
15.

Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats.

Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K, Brenner DA, Ginès P, Bataller R.

Hepatology. 2010 Mar;51(3):942-52. doi: 10.1002/hep.23419.

PMID:
20044807
[PubMed - indexed for MEDLINE]
16.

Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis.

Son G, Hines IN, Lindquist J, Schrum LW, Rippe RA.

Hepatology. 2009 Nov;50(5):1512-23. doi: 10.1002/hep.23186.

PMID:
19790269
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

The anti-fibrotic effect of bone morphogenic protein-7(BMP-7) on liver fibrosis.

Zhong L, Wang X, Wang S, Yang L, Gao H, Yang C.

Int J Med Sci. 2013;10(4):441-50. doi: 10.7150/ijms.5765. Epub 2013 Mar 2.

PMID:
23471555
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes.

Gressner OA, Lahme B, Demirci I, Gressner AM, Weiskirchen R.

J Hepatol. 2007 Nov;47(5):699-710. Epub 2007 Jun 26.

PMID:
17629588
[PubMed - indexed for MEDLINE]
19.

Extracts of Lindera obtusiloba induce antifibrotic effects in hepatic stellate cells via suppression of a TGF-beta-mediated profibrotic gene expression pattern.

Ruehl M, Erben U, Kim K, Freise C, Dagdelen T, Eisele S, Trowitzsch-Kienast W, Zeitz M, Jia J, Stickel F, Somasundaram R.

J Nutr Biochem. 2009 Aug;20(8):597-606. doi: 10.1016/j.jnutbio.2008.06.003. Epub 2008 Sep 27.

PMID:
18824344
[PubMed - indexed for MEDLINE]
20.

Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitro.

Tang LX, He RH, Yang G, Tan JJ, Zhou L, Meng XM, Huang XR, Lan HY.

PLoS One. 2012;7(2):e31350. doi: 10.1371/journal.pone.0031350. Epub 2012 Feb 7.

PMID:
22363627
[PubMed - indexed for MEDLINE]
Free PMC Article

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