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Immunisation with foamy virus Bet fusion proteins as novel strategy for HIV-1 epitope delivery.

Mühle M, Hoffmann K, Löchelt M, Denner J.

Immunol Res. 2013 May;56(1):61-72. doi: 10.1007/s12026-013-8387-x.


Construction and characterisation of replicating foamy viral vectors expressing HIV-1 epitopes recognised by broadly neutralising antibodies.

Mühle M, Hoffmann K, Löchelt M, Denner J.

Antiviral Res. 2013 Nov;100(2):314-20. doi: 10.1016/j.antiviral.2013.09.009. Epub 2013 Sep 20.


Induction of HIV neutralizing antibodies against the MPER of the HIV envelope protein by HA/gp41 chimeric protein-based DNA and VLP vaccines.

Ye L, Wen Z, Dong K, Wang X, Bu Z, Zhang H, Compans RW, Yang C.

PLoS One. 2011;6(5):e14813. doi: 10.1371/journal.pone.0014813. Epub 2011 May 19.


Bovine papillomavirus-like particles presenting conserved epitopes from membrane-proximal external region of HIV-1 gp41 induced mucosal and systemic antibodies.

Zhai Y, Zhong Z, Zariffard M, Spear GT, Qiao L.

Vaccine. 2013 Nov 4;31(46):5422-9. doi: 10.1016/j.vaccine.2013.09.003. Epub 2013 Sep 19.


Evolution of antibody landscape and viral envelope escape in an HIV-1 CRF02_AG infected patient with 4E10-like antibodies.

Dieltjens T, Heyndrickx L, Willems B, Gray E, Van Nieuwenhove L, Grupping K, Vanham G, Janssens W.

Retrovirology. 2009 Dec 14;6:113. doi: 10.1186/1742-4690-6-113.


Analysis of the human immunodeficiency virus type 1 gp41 membrane proximal external region arrayed on hepatitis B surface antigen particles.

Phogat S, Svehla K, Tang M, Spadaccini A, Muller J, Mascola J, Berkower I, Wyatt R.

Virology. 2008 Mar 30;373(1):72-84. Epub 2007 Dec 26.


Immunization with hybrid proteins containing the membrane proximal external region of HIV-1.

Strasz N, Morozov VA, Kreutzberger J, Keller M, Eschricht M, Denner J.

AIDS Res Hum Retroviruses. 2014 May;30(5):498-508. doi: 10.1089/AID.2013.0191. Epub 2014 Feb 7.


Neutralizing antibodies induced by liposomal HIV-1 glycoprotein 41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes.

Matyas GR, Wieczorek L, Beck Z, Ochsenbauer-Jambor C, Kappes JC, Michael NL, Polonis VR, Alving CR.

AIDS. 2009 Oct 23;23(16):2069-77. doi: 10.1097/QAD.0b013e32832faea5.


Multiple antigen peptide mimetics containing gp41 membrane-proximal external region elicit broad neutralizing antibodies against human immunodeficiency virus type 1 in guinea pigs.

Zhang L, Miao L, Gong X, Zhang H, Yang L, Shi Y, Kong W, Jiang C, Shan Y.

J Pept Sci. 2013 Aug;19(8):491-8. doi: 10.1002/psc.2526. Epub 2013 Jun 21.


Conformation-specific display of 4E10 and 2F5 epitopes on self-assembling protein nanoparticles as a potential HIV vaccine.

Wahome N, Pfeiffer T, Ambiel I, Yang Y, Keppler OT, Bosch V, Burkhard P.

Chem Biol Drug Des. 2012 Sep;80(3):349-57. doi: 10.1111/j.1747-0285.2012.01423.x. Epub 2012 Jul 3.


Chemically modified peptides based on the membrane-proximal external region of the HIV-1 envelope induce high-titer, epitope-specific nonneutralizing antibodies in rabbits.

Venditto VJ, Wieczorek L, Molnar S, Teque F, Landucci G, Watson DS, Forthal D, Polonis VR, Levy JA, Szoka FC Jr.

Clin Vaccine Immunol. 2014 Aug;21(8):1086-93. doi: 10.1128/CVI.00320-14. Epub 2014 May 28.


An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10.

Nelson JD, Brunel FM, Jensen R, Crooks ET, Cardoso RM, Wang M, Hessell A, Wilson IA, Binley JM, Dawson PE, Burton DR, Zwick MB.

J Virol. 2007 Apr;81(8):4033-43. Epub 2007 Feb 7.


Antigenic properties of a transport-competent influenza HA/HIV Env chimeric protein.

Ye L, Sun Y, Lin J, Bu Z, Wu Q, Jiang S, Steinhauer DA, Compans RW, Yang C.

Virology. 2006 Aug 15;352(1):74-85. Epub 2006 May 24.


Development and immunological assessment of VLP-based immunogens exposing the membrane-proximal region of the HIV-1 gp41 protein.

Benen TD, Tonks P, Kliche A, Kapzan R, Heeney JL, Wagner R.

J Biomed Sci. 2014 Aug 27;21:79. doi: 10.1186/s12929-014-0079-x.


Deletion of fusion peptide or destabilization of fusion core of HIV gp41 enhances antigenicity and immunogenicity of 4E10 epitope.

Li J, Chen X, Jiang S, Chen YH.

Biochem Biophys Res Commun. 2008 Nov 7;376(1):60-4. doi: 10.1016/j.bbrc.2008.08.105. Epub 2008 Aug 30.


Targeting antibody responses to the membrane proximal external region of the envelope glycoprotein of human immunodeficiency virus.

Kamdem Toukam D, Tenbusch M, Stang A, Temchura V, Storcksdieck Genannt Bonsmann M, Grewe B, Koch S, Meyerhans A, Nchinda G, Kaptue L, Uberla K.

PLoS One. 2012;7(5):e38068. doi: 10.1371/journal.pone.0038068. Epub 2012 May 30.


Generation of neutralising antibodies against porcine endogenous retroviruses (PERVs).

Kaulitz D, Fiebig U, Eschricht M, Wurzbacher C, Kurth R, Denner J.

Virology. 2011 Mar 1;411(1):78-86. doi: 10.1016/j.virol.2010.12.032. Epub 2011 Jan 14.


Neutralizing epitopes in the membrane-proximal external region of HIV-1 gp41 are influenced by the transmembrane domain and the plasma membrane.

Montero M, Gulzar N, Klaric KA, Donald JE, Lepik C, Wu S, Tsai S, Julien JP, Hessell AJ, Wang S, Lu S, Burton DR, Pai EF, Degrado WF, Scott JK.

J Virol. 2012 Mar;86(6):2930-41. doi: 10.1128/JVI.06349-11. Epub 2012 Jan 11.

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