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Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents.

Dalli J, Winkler JW, Colas RA, Arnardottir H, Cheng CY, Chiang N, Petasis NA, Serhan CN.

Chem Biol. 2013 Feb 21;20(2):188-201. doi: 10.1016/j.chembiol.2012.11.010.


Stereocontrolled total synthesis of the potent anti-inflammatory and pro-resolving lipid mediator resolvin D3 and its aspirin-triggered 17R-epimer.

Winkler JW, Uddin J, Serhan CN, Petasis NA.

Org Lett. 2013 Apr 5;15(7):1424-7. doi: 10.1021/ol400484u. Epub 2013 Mar 19.


Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation.

Oh SF, Pillai PS, Recchiuti A, Yang R, Serhan CN.

J Clin Invest. 2011 Feb;121(2):569-81. doi: 10.1172/JCI42545. Epub 2011 Jan 4.


Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation.

Sun YP, Oh SF, Uddin J, Yang R, Gotlinger K, Campbell E, Colgan SP, Petasis NA, Serhan CN.

J Biol Chem. 2007 Mar 30;282(13):9323-34. Epub 2007 Jan 23.


Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers.

Serhan CN, Arita M, Hong S, Gotlinger K.

Lipids. 2004 Nov;39(11):1125-32. Review.


Stereochemical assignment and anti-inflammatory properties of the omega-3 lipid mediator resolvin E3.

Isobe Y, Arita M, Iwamoto R, Urabe D, Todoroki H, Masuda K, Inoue M, Arai H.

J Biochem. 2013 Apr;153(4):355-60. doi: 10.1093/jb/mvs151. Epub 2013 Jan 3.


Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue.

Colas RA, Shinohara M, Dalli J, Chiang N, Serhan CN.

Am J Physiol Cell Physiol. 2014 Jul 1;307(1):C39-54. doi: 10.1152/ajpcell.00024.2014. Epub 2014 Apr 2.


Molecular circuits of resolution: formation and actions of resolvins and protectins.

Bannenberg GL, Chiang N, Ariel A, Arita M, Tjonahen E, Gotlinger KH, Hong S, Serhan CN.

J Immunol. 2005 Apr 1;174(7):4345-55. Erratum in: J Immunol. 2005 May 1;174(9):5884.


Infection regulates pro-resolving mediators that lower antibiotic requirements.

Chiang N, Fredman G, Bäckhed F, Oh SF, Vickery T, Schmidt BA, Serhan CN.

Nature. 2012 Apr 25;484(7395):524-8. doi: 10.1038/nature11042.


Novel n-3 immunoresolvents: structures and actions.

Dalli J, Colas RA, Serhan CN.

Sci Rep. 2013;3:1940. doi: 10.1038/srep01940. Erratum in: Sci Rep. 2014;4:6726.


Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions.

Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite M.

J Exp Med. 2009 Jan 16;206(1):15-23. doi: 10.1084/jem.20081880. Epub 2008 Dec 22.


Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing.

Norling LV, Spite M, Yang R, Flower RJ, Perretti M, Serhan CN.

J Immunol. 2011 May 15;186(10):5543-7. doi: 10.4049/jimmunol.1003865. Epub 2011 Apr 1.


Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus.

Serhan CN, Chiang N.

Br J Pharmacol. 2008 Mar;153 Suppl 1:S200-15. Epub 2007 Oct 29. Review.


Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution.

Kasuga K, Yang R, Porter TF, Agrawal N, Petasis NA, Irimia D, Toner M, Serhan CN.

J Immunol. 2008 Dec 15;181(12):8677-87.


Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines.

Arnardottir HH, Dalli J, Colas RA, Shinohara M, Serhan CN.

J Immunol. 2014 Oct 15;193(8):4235-44. doi: 10.4049/jimmunol.1401313. Epub 2014 Sep 12.


Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury.

Eickmeier O, Seki H, Haworth O, Hilberath JN, Gao F, Uddin M, Croze RH, Carlo T, Pfeffer MA, Levy BD.

Mucosal Immunol. 2013 Mar;6(2):256-66. doi: 10.1038/mi.2012.66. Epub 2012 Jul 11.


Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways.

Dalli J, Ramon S, Norris PC, Colas RA, Serhan CN.

FASEB J. 2015 May;29(5):2120-36. doi: 10.1096/fj.14-268441. Epub 2015 Feb 20.


Resolvins: natural agonists for resolution of pulmonary inflammation.

Uddin M, Levy BD.

Prog Lipid Res. 2011 Jan;50(1):75-88. doi: 10.1016/j.plipres.2010.09.002. Epub 2010 Sep 29. Review.

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