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Results: 1 to 20 of 87

1.

Non-invasive UPR monitoring system and its applications in CHO production cultures.

Du Z, Treiber D, McCoy RE, Miller AK, Han M, He F, Domnitz S, Heath C, Reddy P.

Biotechnol Bioeng. 2013 Aug;110(8):2184-94. doi: 10.1002/bit.24877. Epub 2013 Mar 26.

PMID:
23436541
[PubMed - indexed for MEDLINE]
2.

Assays for detecting the unfolded protein response.

Cawley K, Deegan S, Samali A, Gupta S.

Methods Enzymol. 2011;490:31-51. doi: 10.1016/B978-0-12-385114-7.00002-7.

PMID:
21266242
[PubMed - indexed for MEDLINE]
3.

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.

Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ.

Genes Dev. 2002 Feb 15;16(4):452-66.

PMID:
11850408
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Development of a novel ER stress based selection system for the isolation of highly productive clones.

Kober L, Zehe C, Bode J.

Biotechnol Bioeng. 2012 Oct;109(10):2599-611. doi: 10.1002/bit.24527. Epub 2012 Apr 24.

PMID:
22510960
[PubMed - indexed for MEDLINE]
5.

The cellular response to protein misfolding in the endoplasmic reticulum.

Welihinda AA, Tirasophon W, Kaufman RJ.

Gene Expr. 1999;7(4-6):293-300. Review.

PMID:
10440230
[PubMed - indexed for MEDLINE]
6.

Aberrant accumulation of fibulin-3 in the endoplasmic reticulum leads to activation of the unfolded protein response and VEGF expression.

Roybal CN, Marmorstein LY, Vander Jagt DL, Abcouwer SF.

Invest Ophthalmol Vis Sci. 2005 Nov;46(11):3973-9.

PMID:
16249470
[PubMed - indexed for MEDLINE]
Free Article
7.

Differential protein expression following low temperature culture of suspension CHO-K1 cells.

Kumar N, Gammell P, Meleady P, Henry M, Clynes M.

BMC Biotechnol. 2008 Apr 22;8:42. doi: 10.1186/1472-6750-8-42.

PMID:
18430238
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Effect of shear stress on intrinsic CHO culture state and glycosylation of recombinant tissue-type plasminogen activator protein.

Senger RS, Karim MN.

Biotechnol Prog. 2003 Jul-Aug;19(4):1199-209.

PMID:
12892482
[PubMed - indexed for MEDLINE]
9.

Identification of novel small molecule enhancers of protein production by cultured mammalian cells.

Allen MJ, Boyce JP, Trentalange MT, Treiber DL, Rasmussen B, Tillotson B, Davis R, Reddy P.

Biotechnol Bioeng. 2008 Aug 15;100(6):1193-204. doi: 10.1002/bit.21839.

PMID:
18351681
[PubMed - indexed for MEDLINE]
10.

Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress.

Takayanagi S, Fukuda R, Takeuchi Y, Tsukada S, Yoshida K.

Cell Stress Chaperones. 2013 Jan;18(1):11-23. doi: 10.1007/s12192-012-0351-5. Epub 2012 Jul 18.

PMID:
22802018
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases.

Ryno LM, Wiseman RL, Kelly JW.

Curr Opin Chem Biol. 2013 Jun;17(3):346-52. doi: 10.1016/j.cbpa.2013.04.009. Epub 2013 May 4. Review.

PMID:
23647985
[PubMed - indexed for MEDLINE]
12.

Generation of stable, high-producing CHO cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture.

Oberbek A, Matasci M, Hacker DL, Wurm FM.

Biotechnol Bioeng. 2011 Mar;108(3):600-10. doi: 10.1002/bit.22968. Epub 2010 Nov 23.

PMID:
20967750
[PubMed - indexed for MEDLINE]
13.

Activation of unfolded protein response in transgenic mouse lenses.

Reneker LW, Chen H, Overbeek PA.

Invest Ophthalmol Vis Sci. 2011 Apr 4;52(5):2100-8. doi: 10.1167/iovs.10-5650. Print 2011 Apr.

PMID:
21310900
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Regulation of XBP-1 signaling during transient and stable recombinant protein production in CHO cells.

Ku SC, Toh PC, Lee YY, Chusainow J, Yap MG, Chao SH.

Biotechnol Prog. 2010 Mar-Apr;26(2):517-26. doi: 10.1002/btpr.322.

PMID:
19938059
[PubMed - indexed for MEDLINE]
15.

The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death.

Chambers KT, Unverferth JA, Weber SM, Wek RC, Urano F, Corbett JA.

Diabetes. 2008 Jan;57(1):124-32. Epub 2007 Oct 10.

PMID:
17928398
[PubMed - indexed for MEDLINE]
Free Article
16.

HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.

Merquiol E, Uzi D, Mueller T, Goldenberg D, Nahmias Y, Xavier RJ, Tirosh B, Shibolet O.

PLoS One. 2011;6(9):e24660. doi: 10.1371/journal.pone.0024660. Epub 2011 Sep 19.

PMID:
21949742
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Kar2p availability defines distinct forms of endoplasmic reticulum stress in living cells.

Lajoie P, Moir RD, Willis IM, Snapp EL.

Mol Biol Cell. 2012 Mar;23(5):955-64. doi: 10.1091/mbc.E11-12-0995. Epub 2012 Jan 4.

PMID:
22219379
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The unfolded protein response and proteostasis in Alzheimer disease: preferential activation of autophagy by endoplasmic reticulum stress.

Scheper W, Nijholt DA, Hoozemans JJ.

Autophagy. 2011 Aug;7(8):910-1. Epub 2011 Aug 1.

PMID:
21494086
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Culture temperature modulates aggregation of recombinant antibody in cho cells.

Gomez N, Subramanian J, Ouyang J, Nguyen MD, Hutchinson M, Sharma VK, Lin AA, Yuk IH.

Biotechnol Bioeng. 2012 Jan;109(1):125-36. doi: 10.1002/bit.23288. Epub 2011 Oct 3.

PMID:
21965146
[PubMed - indexed for MEDLINE]
20.

Overexpression of CHOP alone and in combination with chaperones is effective in improving antibody production in mammalian cells.

Nishimiya D, Mano T, Miyadai K, Yoshida H, Takahashi T.

Appl Microbiol Biotechnol. 2013 Mar;97(6):2531-9. doi: 10.1007/s00253-012-4365-9. Epub 2012 Aug 29.

PMID:
22926643
[PubMed - indexed for MEDLINE]
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