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Items: 1 to 20 of 113

1.

Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway.

Lucas K, Maes M.

Mol Neurobiol. 2013 Aug;48(1):190-204. doi: 10.1007/s12035-013-8425-7. Epub 2013 Feb 26. Review.

PMID:
23436141
2.

The Toll-Like Receptor Radical Cycle Pathway: A New Drug Target in Immune-Related Chronic Fatigue.

Lucas K, Morris G, Anderson G, Maes M.

CNS Neurol Disord Drug Targets. 2015;14(7):838-54.

PMID:
25801843
3.
4.

Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.

Lysakova-Devine T, Keogh B, Harrington B, Nagpal K, Halle A, Golenbock DT, Monie T, Bowie AG.

J Immunol. 2010 Oct 1;185(7):4261-71. doi: 10.4049/jimmunol.1002013. Epub 2010 Aug 27.

5.

The TRIPS (Toll-like receptors in immuno-inflammatory pathogenesis) Hypothesis: a novel postulate to understand schizophrenia.

Venkatasubramanian G, Debnath M.

Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 1;44:301-11. doi: 10.1016/j.pnpbp.2013.04.001. Epub 2013 Apr 12.

PMID:
23587629
6.

Loss of Toll-like receptor 2 and 4 leads to differential induction of endoplasmic reticulum stress and proapoptotic responses in the intestinal epithelium under conditions of chronic inflammation.

Messlik A, Schmechel S, Kisling S, Bereswill S, Heimesaat MM, Fischer A, Göbel U, Haller D.

J Proteome Res. 2009 Oct;8(10):4406-17. doi: 10.1021/pr9000465.

PMID:
19681597
7.

Respiratory syncytial virus fusion protein-induced toll-like receptor 4 (TLR4) signaling is inhibited by the TLR4 antagonists Rhodobacter sphaeroides lipopolysaccharide and eritoran (E5564) and requires direct interaction with MD-2.

Rallabhandi P, Phillips RL, Boukhvalova MS, Pletneva LM, Shirey KA, Gioannini TL, Weiss JP, Chow JC, Hawkins LD, Vogel SN, Blanco JC.

MBio. 2012 Aug 7;3(4). pii: e00218-12. doi: 10.1128/mBio.00218-12. Print 2012.

8.

Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists.

Peri F, Piazza M.

Biotechnol Adv. 2012 Jan-Feb;30(1):251-60. doi: 10.1016/j.biotechadv.2011.05.014. Epub 2011 Jun 6. Review.

PMID:
21664961
9.

Endotoxin, TLR4 signaling and vascular inflammation: potential therapeutic targets in cardiovascular disease.

Stoll LL, Denning GM, Weintraub NL.

Curr Pharm Des. 2006;12(32):4229-45. Review.

PMID:
17100625
10.
11.

Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells.

Xia MZ, Liang YL, Wang H, Chen X, Huang YY, Zhang ZH, Chen YH, Zhang C, Zhao M, Xu DX, Song LH.

J Pineal Res. 2012 Nov;53(4):325-34. doi: 10.1111/j.1600-079X.2012.01002.x. Epub 2012 Apr 27.

PMID:
22537289
12.

Alteration of Toll-like receptor 4 activation by 4-hydroxy-2-nonenal mediated by the suppression of receptor homodimerization.

Kim YS, Park ZY, Kim SY, Jeong E, Lee JY.

Chem Biol Interact. 2009 Nov 10;182(1):59-66. doi: 10.1016/j.cbi.2009.07.009. Epub 2009 Jul 21.

PMID:
19627980
13.

Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4.

Guillot L, Medjane S, Le-Barillec K, Balloy V, Danel C, Chignard M, Si-Tahar M.

J Biol Chem. 2004 Jan 23;279(4):2712-8. Epub 2003 Nov 4.

14.

The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung.

Wieland CW, Florquin S, Maris NA, Hoebe K, Beutler B, Takeda K, Akira S, van der Poll T.

J Immunol. 2005 Nov 1;175(9):6042-9.

15.

Stress-induced neuroinflammation: role of the Toll-like receptor-4 pathway.

Gárate I, Garcia-Bueno B, Madrigal JL, Caso JR, Alou L, Gomez-Lus ML, Micó JA, Leza JC.

Biol Psychiatry. 2013 Jan 1;73(1):32-43. doi: 10.1016/j.biopsych.2012.07.005. Epub 2012 Aug 18.

PMID:
22906518
16.

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.

Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA.

Nature. 2001 Sep 6;413(6851):78-83.

PMID:
11544529
17.

The Janus face of Bartonella quintana recognition by Toll-like receptors (TLRs): a review.

Matera G, Liberto MC, Joosten LA, Vinci M, Quirino A, Pulicari MC, Kullberg BJ, Van der Meer JW, Netea MG, Focà A.

Eur Cytokine Netw. 2008 Sep;19(3):113-8. doi: 10.1684/ecn.2008.0128. Epub 2008 Sep 8. Review.

PMID:
18775802
18.

Endotoxin induces toll-like receptor 4 expression in vascular smooth muscle cells via NADPH oxidase activation and mitogen-activated protein kinase signaling pathways.

Lin FY, Chen YH, Tasi JS, Chen JW, Yang TL, Wang HJ, Li CY, Chen YL, Lin SJ.

Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2630-7. Epub 2006 Sep 28.

19.

Increased levels of the high mobility group box 1 protein sustain the inflammatory bone marrow microenvironment in patients with chronic idiopathic neutropenia via activation of toll-like receptor 4.

Velegraki M, Koutala H, Tsatsanis C, Papadaki HA.

J Clin Immunol. 2012 Apr;32(2):312-22. doi: 10.1007/s10875-011-9620-9. Epub 2011 Nov 30.

PMID:
22127462
20.
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