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Akt and c-Myc induce stem-cell markers in mature primary p53⁻/⁻ astrocytes and render these cells gliomagenic in the brain of immunocompetent mice.

Radke J, Bortolussi G, Pagenstecher A.

PLoS One. 2013;8(2):e56691. doi: 10.1371/journal.pone.0056691. Epub 2013 Feb 12. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/562d2594-464f-49f1-90ef-f78cafcd3956.


p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.

Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, DePinho RA.

Nature. 2008 Oct 23;455(7216):1129-33. doi: 10.1038/nature07443.


Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma.

Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, dePinho RA.

Cold Spring Harb Symp Quant Biol. 2008;73:427-37. doi: 10.1101/sqb.2008.73.047. Epub 2009 Jan 15.


Cyclophilin B supports Myc and mutant p53-dependent survival of glioblastoma multiforme cells.

Choi JW, Schroeder MA, Sarkaria JN, Bram RJ.

Cancer Res. 2014 Jan 15;74(2):484-96. doi: 10.1158/0008-5472.CAN-13-0771. Epub 2013 Nov 22.


Girdin maintains the stemness of glioblastoma stem cells.

Natsume A, Kato T, Kinjo S, Enomoto A, Toda H, Shimato S, Ohka F, Motomura K, Kondo Y, Miyata T, Takahashi M, Wakabayashi T.

Oncogene. 2012 May 31;31(22):2715-24. doi: 10.1038/onc.2011.466. Epub 2011 Oct 24.


Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model.

Endersby R, Zhu X, Hay N, Ellison DW, Baker SJ.

Cancer Res. 2011 Jun 15;71(12):4106-16. doi: 10.1158/0008-5472.CAN-10-3597. Epub 2011 Apr 20.


c-Myc is required for maintenance of glioma cancer stem cells.

Wang J, Wang H, Li Z, Wu Q, Lathia JD, McLendon RE, Hjelmeland AB, Rich JN.

PLoS One. 2008;3(11):e3769. doi: 10.1371/journal.pone.0003769. Epub 2008 Nov 20.


YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells.

Mantwill K, Naumann U, Seznec J, Girbinger V, Lage H, Surowiak P, Beier D, Mittelbronn M, Schlegel J, Holm PS.

J Transl Med. 2013 Sep 18;11:216. doi: 10.1186/1479-5876-11-216.


Brain cancer stem-like cell genesis from p53-deficient mouse astrocytes by oncogenic Ras.

Lee JS, Gil JE, Kim JH, Kim TK, Jin X, Oh SY, Sohn YW, Jeon HM, Park HJ, Park JW, Shin YJ, Chung YG, Lee JB, You S, Kim H.

Biochem Biophys Res Commun. 2008 Jan 18;365(3):496-502. Epub 2007 Nov 20.


Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma.

Sonoda Y, Ozawa T, Aldape KD, Deen DF, Berger MS, Pieper RO.

Cancer Res. 2001 Sep 15;61(18):6674-8.


Could changes in the regulation of the PI3K/PKB/Akt signaling pathway and cell cycle be involved in astrocytic tumor pathogenesis and progression?

Hlobilkova A, Ehrmann J, Sedlakova E, Krejci V, Knizetova P, Fiuraskova M, Kala M, Kalita O, Kolar Z.

Neoplasma. 2007;54(4):334-41.


Mouse induced glioma-initiating cell models and therapeutic targets.

Kondo T.

Anticancer Agents Med Chem. 2010 Jul;10(6):471-80.


FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes.

Dai B, Pieper RO, Li D, Wei P, Liu M, Woo SY, Aldape KD, Sawaya R, Xie K, Huang S.

Cancer Res. 2010 Apr 1;70(7):2951-61. doi: 10.1158/0008-5472.CAN-09-3909. Epub 2010 Mar 23.


Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells.

Motohara T, Masuko S, Ishimoto T, Yae T, Onishi N, Muraguchi T, Hirao A, Matsuzaki Y, Tashiro H, Katabuchi H, Saya H, Nagano O.

Carcinogenesis. 2011 Nov;32(11):1597-606. doi: 10.1093/carcin/bgr183. Epub 2011 Aug 8.


Malignant transformation of p53-deficient astrocytes is modulated by environmental cues in vitro.

Bögler O, Nagane M, Gillis J, Huang HJ, Cavenee WK.

Cell Growth Differ. 1999 Feb;10(2):73-86.


Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma.

Sonoda Y, Ozawa T, Hirose Y, Aldape KD, McMahon M, Berger MS, Pieper RO.

Cancer Res. 2001 Jul 1;61(13):4956-60.


Loss of p53 cooperates with K-ras activation to induce glioma formation in a region-independent manner.

Muñoz DM, Tung T, Agnihotri S, Singh S, Guha A, Zadeh G, Hawkins C.

Glia. 2013 Nov;61(11):1862-72. doi: 10.1002/glia.22563. Epub 2013 Aug 30.

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