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Results: 1 to 20 of 102

1.

Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics.

Lee HW, Kyung T, Yoo J, Kim T, Chung C, Ryu JY, Lee H, Park K, Lee S, Jones WD, Lim DS, Hyeon C, Heo WD, Yoon TY.

Nat Commun. 2013;4:1505. doi: 10.1038/ncomms2507.

PMID:
23422673
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S.

Nature. 2010 Mar 18;464(7287):431-5. doi: 10.1038/nature08833. Epub 2010 Feb 3.

PMID:
20130576
[PubMed - indexed for MEDLINE]
3.

Change in protein flexibility upon complex formation: analysis of Ras-Raf using molecular dynamics and a molecular framework approach.

Gohlke H, Kuhn LA, Case DA.

Proteins. 2004 Aug 1;56(2):322-37.

PMID:
15211515
[PubMed - indexed for MEDLINE]
4.

Identification, using molecular dynamics, of an effector domain of the ras-binding domain of the raf-p74 protein that is uniquely involved in oncogenic ras-p21 signaling.

Chen JM, Rijhwani K, Friedman FK, Hyde MJ, Pincus MR.

J Protein Chem. 2000 Oct;19(7):545-51.

PMID:
11233167
[PubMed - indexed for MEDLINE]
5.

The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways.

Caraglia M, Marra M, Viscomi C, D'Alessandro AM, Budillon A, Meo G, Arra C, Barbieri A, Rapp UR, Baldi A, Tassone P, Venuta S, Abbruzzese A, Tagliaferri P.

Int J Cancer. 2007 Nov 15;121(10):2317-30. Erratum in: Int J Cancer. 2008 Apr 15;122(8):1922.

PMID:
17657738
[PubMed - indexed for MEDLINE]
6.

Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.

Molzan M, Schumacher B, Ottmann C, Baljuls A, Polzien L, Weyand M, Thiel P, Rose R, Rose M, Kuhenne P, Kaiser M, Rapp UR, Kuhlmann J, Ottmann C.

Mol Cell Biol. 2010 Oct;30(19):4698-711. doi: 10.1128/MCB.01636-09. Epub 2010 Aug 2.

PMID:
20679480
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Cell type-specific importance of ras-c-raf complex association rate constants for MAPK signaling.

Kiel C, Serrano L.

Sci Signal. 2009 Jul 28;2(81):ra38. doi: 10.1126/scisignal.2000397.

PMID:
19638615
[PubMed - indexed for MEDLINE]
Free Article
8.

Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS.

Tanaka T, Williams RL, Rabbitts TH.

EMBO J. 2007 Jul 11;26(13):3250-9. Epub 2007 Jun 14.

PMID:
17568777
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Opposite role of Ras in tumor necrosis factor-alpha-induced cell cycle regulation: competition for Raf kinase.

Park SJ, Kim YY, Lim JY, Seo GJ, Kim J, Park SI, Park BJ.

Biochem Biophys Res Commun. 2001 Oct 12;287(5):1140-7.

PMID:
11587542
[PubMed - indexed for MEDLINE]
10.

Functional interactions of Raf and MEK with Jun-N-terminal kinase (JNK) result in a positive feedback loop on the oncogenic Ras signaling pathway.

Adler V, Qu Y, Smith SJ, Izotova L, Pestka S, Kung HF, Lin M, Friedman FK, Chie L, Chung D, Boutjdir M, Pincus MR.

Biochemistry. 2005 Aug 16;44(32):10784-95.

PMID:
16086581
[PubMed - indexed for MEDLINE]
11.

Differential structural requirements for interaction of Ras protein with its distinct downstream effectors.

Akasaka K, Tamada M, Wang F, Kariya K, Shima F, Kikuchi A, Yamamoto M, Shirouzu M, Yokoyama S, Kataoka T.

J Biol Chem. 1996 Mar 8;271(10):5353-60.

PMID:
8621388
[PubMed - indexed for MEDLINE]
Free Article
12.

Real-time single-molecule coimmunoprecipitation of weak protein-protein interactions.

Lee HW, Ryu JY, Yoo J, Choi B, Kim K, Yoon TY.

Nat Protoc. 2013 Oct;8(10):2045-60. doi: 10.1038/nprot.2013.116. Epub 2013 Sep 26.

PMID:
24071910
[PubMed - indexed for MEDLINE]
13.

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.

Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG.

J Clin Invest. 2004 Feb;113(4):539-50.

PMID:
14966563
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2.

Jelinek T, Catling AD, Reuter CW, Moodie SA, Wolfman A, Weber MJ.

Mol Cell Biol. 1994 Dec;14(12):8212-8.

PMID:
7969158
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro.

Warne PH, Viciana PR, Downward J.

Nature. 1993 Jul 22;364(6435):352-5.

PMID:
8332195
[PubMed - indexed for MEDLINE]
16.

Transient kinetic studies on the interaction of Ras and the Ras-binding domain of c-Raf-1 reveal rapid equilibration of the complex.

Sydor JR, Engelhard M, Wittinghofer A, Goody RS, Herrmann C.

Biochemistry. 1998 Oct 6;37(40):14292-9.

PMID:
9760267
[PubMed - indexed for MEDLINE]
17.

Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.

Terai K, Matsuda M.

EMBO Rep. 2005 Mar;6(3):251-5.

PMID:
15711535
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

A RasGTP-induced conformational change in C-RAF is essential for accurate molecular recognition.

Hibino K, Shibata T, Yanagida T, Sako Y.

Biophys J. 2009 Sep 2;97(5):1277-87. doi: 10.1016/j.bpj.2009.05.048.

PMID:
19720015
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors.

Skobeleva N, Menon S, Weber L, Golemis EA, Khazak V.

Mol Cancer Ther. 2007 Mar;6(3):898-906.

PMID:
17363484
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation.

Grammatikakis N, Vultur A, Ramana CV, Siganou A, Schweinfest CW, Watson DK, Raptis L.

J Biol Chem. 2002 Mar 8;277(10):8312-20. Epub 2001 Dec 20.

PMID:
11751906
[PubMed - indexed for MEDLINE]
Free Article

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