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Items: 1 to 20 of 109

1.

Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor.

Zhang L, Xu M, Scotti E, Chen ZJ, Tontonoz P.

J Lipid Res. 2013 May;54(5):1410-20. doi: 10.1194/jlr.M035774. Epub 2013 Feb 18.

2.

Distinct functional domains contribute to degradation of the low density lipoprotein receptor (LDLR) by the E3 ubiquitin ligase inducible Degrader of the LDLR (IDOL).

Sorrentino V, Scheer L, Santos A, Reits E, Bleijlevens B, Zelcer N.

J Biol Chem. 2011 Aug 26;286(34):30190-9. doi: 10.1074/jbc.M111.249557. Epub 2011 Jul 6.

3.

The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL.

Nelson JK, Sorrentino V, Avagliano Trezza R, Heride C, Urbe S, Distel B, Zelcer N.

Circ Res. 2016 Feb 5;118(3):410-9. doi: 10.1161/CIRCRESAHA.115.307298. Epub 2015 Dec 14.

PMID:
26666640
4.

The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.

Sorrentino V, Nelson JK, Maspero E, Marques AR, Scheer L, Polo S, Zelcer N.

J Lipid Res. 2013 Aug;54(8):2174-84. doi: 10.1194/jlr.M037713. Epub 2013 Jun 3.

5.

IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor.

Scotti E, Calamai M, Goulbourne CN, Zhang L, Hong C, Lin RR, Choi J, Pilch PF, Fong LG, Zou P, Ting AY, Pavone FS, Young SG, Tontonoz P.

Mol Cell Biol. 2013 Apr;33(8):1503-14. doi: 10.1128/MCB.01716-12. Epub 2013 Feb 4.

6.

Post-transcriptional regulation of lipoprotein receptors by the E3-ubiquitin ligase inducible degrader of the low-density lipoprotein receptor.

Sorrentino V, Zelcer N.

Curr Opin Lipidol. 2012 Jun;23(3):213-9. doi: 10.1097/MOL.0b013e3283532947. Review.

PMID:
22510808
7.

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.

Zhang L, Fairall L, Goult BT, Calkin AC, Hong C, Millard CJ, Tontonoz P, Schwabe JW.

Genes Dev. 2011 Jun 15;25(12):1262-74. doi: 10.1101/gad.2056211.

8.

Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.

Nelson JK, Cook EC, Loregger A, Hoeksema MA, Scheij S, Kovacevic I, Hordijk PL, Ovaa H, Zelcer N.

J Biol Chem. 2016 Feb 26;291(9):4813-25. doi: 10.1074/jbc.M115.698688. Epub 2015 Dec 30.

PMID:
26719329
9.

Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists.

Scotti E, Hong C, Yoshinaga Y, Tu Y, Hu Y, Zelcer N, Boyadjian R, de Jong PJ, Young SG, Fong LG, Tontonoz P.

Mol Cell Biol. 2011 May;31(9):1885-93. doi: 10.1128/MCB.01469-10. Epub 2011 Feb 22.

10.

The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.

Hong C, Duit S, Jalonen P, Out R, Scheer L, Sorrentino V, Boyadjian R, Rodenburg KW, Foley E, Korhonen L, Lindholm D, Nimpf J, van Berkel TJ, Tontonoz P, Zelcer N.

J Biol Chem. 2010 Jun 25;285(26):19720-6. doi: 10.1074/jbc.M110.123729. Epub 2010 Apr 28.

11.

ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination.

Marx C, Held JM, Gibson BW, Benz CC.

Cancer Res. 2010 May 1;70(9):3709-17. doi: 10.1158/0008-5472.CAN-09-3768. Epub 2010 Apr 20.

12.

Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis.

Zhang L, Reue K, Fong LG, Young SG, Tontonoz P.

Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2541-6. doi: 10.1161/ATVBAHA.112.250571. Epub 2012 Aug 30. Review.

13.

LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.

Zelcer N, Hong C, Boyadjian R, Tontonoz P.

Science. 2009 Jul 3;325(5936):100-4. doi: 10.1126/science.1168974. Epub 2009 Jun 11.

14.

FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors.

Calkin AC, Goult BT, Zhang L, Fairall L, Hong C, Schwabe JW, Tontonoz P.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20107-12. doi: 10.1073/pnas.1111589108. Epub 2011 Nov 22.

15.

NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation.

Pietiäinen V, Vassilev B, Blom T, Wang W, Nelson J, Bittman R, Bäck N, Zelcer N, Ikonen E.

J Cell Sci. 2013 Sep 1;126(Pt 17):3961-71. doi: 10.1242/jcs.128132. Epub 2013 Jun 26.

16.

Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap).

Do HT, Tselykh TV, Mäkelä J, Ho TH, Olkkonen VM, Bornhauser BC, Korhonen L, Zelcer N, Lindholm D.

J Biol Chem. 2012 Apr 13;287(16):12602-11. doi: 10.1074/jbc.M112.341248. Epub 2012 Feb 29.

17.

Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination.

Lim GG, Chew KC, Ng XH, Henry-Basil A, Sim RW, Tan JM, Chai C, Lim KL.

PLoS One. 2013 Sep 2;8(9):e73235. doi: 10.1371/journal.pone.0073235. eCollection 2013.

18.

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

Nathan JA, Kim HT, Ting L, Gygi SP, Goldberg AL.

EMBO J. 2013 Feb 20;32(4):552-65. doi: 10.1038/emboj.2012.354. Epub 2013 Jan 11.

19.

Lysine 63-linked polyubiquitination is required for EGF receptor degradation.

Huang F, Zeng X, Kim W, Balasubramani M, Fortian A, Gygi SP, Yates NA, Sorkin A.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15722-7. doi: 10.1073/pnas.1308014110. Epub 2013 Sep 9.

20.

Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and ubiquitination.

Wang Y, Guan S, Acharya P, Koop DR, Liu Y, Liao M, Burlingame AL, Correia MA.

J Biol Chem. 2011 Mar 18;286(11):9443-56. doi: 10.1074/jbc.M110.176685. Epub 2011 Jan 5.

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