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Related Citations for PubMed (Select 23418776)


Mapping of interactions between the N- and C-termini and the channel core in HERG K+ channels.

de la Peña P, Machín A, Fernández-Trillo J, Domínguez P, Barros F.

Biochem J. 2013 May 1;451(3):463-74. doi: 10.1042/BJ20121717.


Demonstration of physical proximity between the N terminus and the S4-S5 linker of the human ether-a-go-go-related gene (hERG) potassium channel.

de la Peña P, Alonso-Ron C, Machín A, Fernández-Trillo J, Carretero L, Domínguez P, Barros F.

J Biol Chem. 2011 May 27;286(21):19065-75. doi: 10.1074/jbc.M111.238899. Epub 2011 Apr 7.


Structural and functional role of the extracellular s5-p linker in the HERG potassium channel.

Liu J, Zhang M, Jiang M, Tseng GN.

J Gen Physiol. 2002 Nov;120(5):723-37.


The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel.

Ferrer T, Rupp J, Piper DR, Tristani-Firouzi M.

J Biol Chem. 2006 May 5;281(18):12858-64. Epub 2006 Mar 8.


Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels.

Gianulis EC, Liu Q, Trudeau MC.

J Gen Physiol. 2013 Oct;142(4):351-66. doi: 10.1085/jgp.201310995. Epub 2013 Sep 16.


Differential effects of amino-terminal distal and proximal domains in the regulation of human erg K(+) channel gating.

Viloria CG, Barros F, Giráldez T, Gómez-Varela D, de la Peña P.

Biophys J. 2000 Jul;79(1):231-46.


The eag domain regulates hERG channel inactivation gating via a direct interaction.

Gustina AS, Trudeau MC.

J Gen Physiol. 2013 Feb;141(2):229-41. doi: 10.1085/jgp.201210870. Epub 2013 Jan 14.


The neutral, hydrophobic isoleucine at position I521 in the extracellular S4 domain of hERG contributes to channel gating equilibrium.

Dou Y, Goodchild SJ, Velde RV, Wu Y, Fedida D.

Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C468-78. doi: 10.1152/ajpcell.00147.2013. Epub 2013 Jun 12.


Regulation of deactivation by an amino terminal domain in human ether-à-go-go-related gene potassium channels.

Wang J, Trudeau MC, Zappia AM, Robertson GA.

J Gen Physiol. 1998 Nov;112(5):637-47. Erratum in: J Gen Physiol 1999 Feb;113(2):359.


Thermodynamic and kinetic properties of amino-terminal and S4-S5 loop HERG channel mutants under steady-state conditions.

Alonso-Ron C, de la Peña P, Miranda P, Domínguez P, Barros F.

Biophys J. 2008 May 15;94(10):3893-911. doi: 10.1529/biophysj.107.116731. Epub 2008 Jan 25.


hERG potassium channel gating is mediated by N- and C-terminal region interactions.

Gustina AS, Trudeau MC.

J Gen Physiol. 2011 Mar;137(3):315-25. doi: 10.1085/jgp.201010582.


Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation.

Chen J, Zou A, Splawski I, Keating MT, Sanguinetti MC.

J Biol Chem. 1999 Apr 9;274(15):10113-8.


Effect of S5P alpha-helix charge mutants on inactivation of hERG K+ channels.

Clarke CE, Hill AP, Zhao J, Kondo M, Subbiah RN, Campbell TJ, Vandenberg JI.

J Physiol. 2006 Jun 1;573(Pt 2):291-304. Epub 2006 Mar 23.


The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation.

Ng CA, Hunter MJ, Perry MD, Mobli M, Ke Y, Kuchel PW, King GF, Stock D, Vandenberg JI.

PLoS One. 2011 Jan 13;6(1):e16191. doi: 10.1371/journal.pone.0016191.


Cysteines control the N- and C-linker-dependent gating of KCNH1 potassium channels.

Sahoo N, Schönherr R, Hoshi T, Heinemann SH.

Biochim Biophys Acta. 2012 May;1818(5):1187-95. doi: 10.1016/j.bbamem.2012.01.021. Epub 2012 Jan 28.


Molecular determinants of interactions between the N-terminal domain and the transmembrane core that modulate hERG K+ channel gating.

Fernández-Trillo J, Barros F, Machín A, Carretero L, Domínguez P, de la Peña P.

PLoS One. 2011;6(9):e24674. doi: 10.1371/journal.pone.0024674. Epub 2011 Sep 15.


Mechanistic insight into human ether-à-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domain.

Muskett FW, Thouta S, Thomson SJ, Bowen A, Stansfeld PJ, Mitcheson JS.

J Biol Chem. 2011 Feb 25;286(8):6184-91. doi: 10.1074/jbc.M110.199364. Epub 2010 Dec 6.


Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.

Perry M, Sachse FB, Sanguinetti MC.

Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13827-32. Epub 2007 Aug 10.


Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed.

Subbiah RN, Kondo M, Campbell TJ, Vandenberg JI.

J Physiol. 2005 Dec 1;569(Pt 2):367-79. Epub 2005 Sep 15.

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