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Results: 1 to 20 of 103

Similar articles for PubMed (Select 23416002)

1.

Amino acid derived quinazolines as Rock/PKA inhibitors.

Chowdhury S, Chen YT, Fang X, Grant W, Pocas J, Cameron MD, Ruiz C, Lin L, Park H, Schröter T, Bannister TD, Lograsso PV, Feng Y.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1592-9. doi: 10.1016/j.bmcl.2013.01.109. Epub 2013 Jan 31.

PMID:
23416002
2.

Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors.

Fang X, Chen YT, Sessions EH, Chowdhury S, Vojkovsky T, Yin Y, Pocas JR, Grant W, Schröter T, Lin L, Ruiz C, Cameron MD, LoGrasso P, Bannister TD, Feng Y.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1844-8. doi: 10.1016/j.bmcl.2011.01.039. Epub 2011 Jan 14.

PMID:
21349713
3.

Effect of the structure of adenosine mimic of bisubstrate-analog inhibitors on their activity towards basophilic protein kinases.

Enkvist E, Kriisa M, Roben M, Kadak G, Raidaru G, Uri A.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6098-101. doi: 10.1016/j.bmcl.2009.09.026. Epub 2009 Sep 12.

PMID:
19800227
4.

High-affinity bisubstrate probe for fluorescence anisotropy binding/displacement assays with protein kinases PKA and ROCK.

Vaasa A, Viil I, Enkvist E, Viht K, Raidaru G, Lavogina D, Uri A.

Anal Biochem. 2009 Feb 1;385(1):85-93. doi: 10.1016/j.ab.2008.10.030. Epub 2008 Oct 31.

PMID:
19017524
5.

The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.

Jacobs M, Hayakawa K, Swenson L, Bellon S, Fleming M, Taslimi P, Doran J.

J Biol Chem. 2006 Jan 6;281(1):260-8. Epub 2005 Oct 24.

6.

Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity.

Bonn S, Herrero S, Breitenlechner CB, Erlbruch A, Lehmann W, Engh RA, Gassel M, Bossemeyer D.

J Biol Chem. 2006 Aug 25;281(34):24818-30. Epub 2006 May 12.

7.

4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: potent and selective p70S6 kinase inhibitors.

Bandarage U, Hare B, Parsons J, Pham L, Marhefka C, Bemis G, Tang Q, Moody CS, Rodems S, Shah S, Adams C, Bravo J, Charonnet E, Savic V, Come JH, Green J.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5191-4. doi: 10.1016/j.bmcl.2009.07.022. Epub 2009 Jul 9.

PMID:
19632115
8.

Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.

Ray P, Wright J, Adam J, Boucharens S, Black D, Brown AR, Epemolu O, Fletcher D, Huggett M, Jones P, Laats S, Lyons A, de Man J, Morphy R, Sherborne B, Sherry L, Straten Nv, Westwood P, York M.

Bioorg Med Chem Lett. 2011 Feb 15;21(4):1084-8. doi: 10.1016/j.bmcl.2010.12.104. Epub 2010 Dec 28.

PMID:
21251828
9.

Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA.

Xu R, Banka A, Blake JF, Mitchell IS, Wallace EM, Bencsik JR, Kallan NC, Spencer KL, Gloor SL, Martinson M, Risom T, Gross SD, Morales TH, Wu WI, Vigers GP, Brandhuber BJ, Skelton NJ.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2335-40. doi: 10.1016/j.bmcl.2011.02.098. Epub 2011 Feb 26.

PMID:
21420856
10.

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.

Schäfer G, Milić J, Eldahshan A, Götz F, Zühlke K, Schillinger C, Kreuchwig A, Elkins JM, Abdul Azeez KR, Oder A, Moutty MC, Masada N, Beerbaum M, Schlegel B, Niquet S, Schmieder P, Krause G, von Kries JP, Cooper DM, Knapp S, Rademann J, Rosenthal W, Klussmann E.

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12187-91. doi: 10.1002/anie.201304686. Epub 2013 Sep 23. No abstract available.

11.

Triazine and pyrimidine based ROCK inhibitors with efficacy in spontaneous hypertensive rat model.

Ho KK, Beasley JR, Belanger L, Black D, Chan JH, Dunn D, Hu B, Klon A, Kultgen SG, Ohlmeyer M, Parlato SM, Ray PC, Pham Q, Rong Y, Roughton AL, Walker TL, Wright J, Xu K, Xu Y, Zhang L, Webb M.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6027-31. doi: 10.1016/j.bmcl.2009.09.046. Epub 2009 Sep 17.

PMID:
19800787
12.

Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors.

Yin Y, Lin L, Ruiz C, Khan S, Cameron MD, Grant W, Pocas J, Eid N, Park H, Schröter T, Lograsso PV, Feng Y.

J Med Chem. 2013 May 9;56(9):3568-81. doi: 10.1021/jm400062r. Epub 2013 Apr 25.

PMID:
23570561
13.

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.

Yin Y, Lin L, Ruiz C, Cameron MD, Pocas J, Grant W, Schröter T, Chen W, Duckett D, Schürer S, Lograsso P, Feng Y.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6686-90. doi: 10.1016/j.bmcl.2009.09.115. Epub 2009 Oct 3.

PMID:
19837589
14.

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).

Chowdhury S, Sessions EH, Pocas JR, Grant W, Schröter T, Lin L, Ruiz C, Cameron MD, Schürer S, LoGrasso P, Bannister TD, Feng Y.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7107-12. doi: 10.1016/j.bmcl.2011.09.083. Epub 2011 Sep 24.

PMID:
22004718
15.

Synthesis and quantum chemical studies of new 4-aminoquinazoline derivatives as Aurora A/B kinase inhibitors.

Zheng M, Zheng Y, Xue Y, Liu Y, An L, Zhang L, Ji M, Xue B, Wu X, Gong X, Gu N, Zhan X.

Chem Biol Drug Des. 2013 Mar;81(3):399-407. doi: 10.1111/cbdd.12089. Epub 2012 Dec 26.

PMID:
23279802
16.

Novel oxazolo[4,5-g]quinazolin-2(1H)-ones: dual inhibitors of EGFR and Src protein tyrosine kinases.

Lin J, Shen W, Xue J, Sun J, Zhang X, Zhang C.

Eur J Med Chem. 2012 Sep;55:39-48. doi: 10.1016/j.ejmech.2012.06.055. Epub 2012 Jul 7.

PMID:
22818848
17.

Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.

Ray P, Wright J, Adam J, Bennett J, Boucharens S, Black D, Cook A, Brown AR, Epemolu O, Fletcher D, Haunso A, Huggett M, Jones P, Laats S, Lyons A, Mestres J, de Man J, Morphy R, Rankovic Z, Sherborne B, Sherry L, van Straten N, Westwood P, Zaman GZ.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):97-101. doi: 10.1016/j.bmcl.2010.11.060. Epub 2010 Nov 19.

PMID:
21145740
18.

Benzimidazole- and benzoxazole-based inhibitors of Rho kinase.

Sessions EH, Yin Y, Bannister TD, Weiser A, Griffin E, Pocas J, Cameron MD, Ruiz C, Lin L, Schürer SC, Schröter T, LoGrasso P, Feng Y.

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6390-3. doi: 10.1016/j.bmcl.2008.10.095. Epub 2008 Oct 25.

PMID:
18996009
19.

Molecular modeling studies of Rho kinase inhibitors using molecular docking and 3D-QSAR analysis.

Qin J, Lei B, Xi L, Liu H, Yao X.

Eur J Med Chem. 2010 Jul;45(7):2768-76. doi: 10.1016/j.ejmech.2010.02.059. Epub 2010 Mar 4.

PMID:
20347188
20.

The development of benzimidazoles as selective rho kinase inhibitors.

Sessions EH, Smolinski M, Wang B, Frackowiak B, Chowdhury S, Yin Y, Chen YT, Ruiz C, Lin L, Pocas J, Schröter T, Cameron MD, LoGrasso P, Feng Y, Bannister TD.

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1939-43. doi: 10.1016/j.bmcl.2010.01.124. Epub 2010 Feb 1.

PMID:
20167489
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