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Results: 1 to 20 of 94

1.

Discovery of a novel series of quinolone α7 nicotinic acetylcholine receptor agonists.

McDonald IM, Mate RA, Zusi FC, Huang H, Post-Munson DJ, Ferrante MA, Gallagher L, Bertekap RL Jr, Knox RJ, Robertson BJ, Harden DG, Morgan DG, Lodge NJ, Dworetzky SI, Olson RE, Macor JE.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1684-8. doi: 10.1016/j.bmcl.2013.01.070. Epub 2013 Jan 29.

PMID:
23414838
[PubMed - indexed for MEDLINE]
2.

Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors.

Bodnar AL, Cortes-Burgos LA, Cook KK, Dinh DM, Groppi VE, Hajos M, Higdon NR, Hoffmann WE, Hurst RS, Myers JK, Rogers BN, Wall TM, Wolfe ML, Wong E.

J Med Chem. 2005 Feb 24;48(4):905-8.

PMID:
15715459
[PubMed - indexed for MEDLINE]
3.

Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.

Enz A, Feuerbach D, Frederiksen MU, Gentsch C, Hurth K, Müller W, Nozulak J, Roy BL.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1287-91. doi: 10.1016/j.bmcl.2009.01.073. Epub 2009 Feb 7.

PMID:
19208472
[PubMed - indexed for MEDLINE]
4.

Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists.

O'Donnell CJ, Peng L, O'Neill BT, Arnold EP, Mather RJ, Sands SB, Shrikhande A, Lebel LA, Spracklin DK, Nedza FM.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4747-51. doi: 10.1016/j.bmcl.2009.06.059. Epub 2009 Jun 17.

PMID:
19576766
[PubMed - indexed for MEDLINE]
5.

Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor.

Mortell KH, Schrimpf MR, Bunnelle WH, Anderson DJ, Gronlien JH, Hagene KT, Gopalakrishnan M.

Bioorg Med Chem Lett. 2010 Jan 1;20(1):104-7. doi: 10.1016/j.bmcl.2009.11.023. Epub 2009 Nov 14.

PMID:
19954975
[PubMed - indexed for MEDLINE]
6.

Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789).

Zanaletti R, Bettinetti L, Castaldo C, Cocconcelli G, Comery T, Dunlop J, Gaviraghi G, Ghiron C, Haydar SN, Jow F, Maccari L, Micco I, Nencini A, Scali C, Turlizzi E, Valacchi M.

J Med Chem. 2012 May 24;55(10):4806-23. doi: 10.1021/jm300247y. Epub 2012 May 3.

PMID:
22468936
[PubMed - indexed for MEDLINE]
7.

Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914).

Ghiron C, Haydar SN, Aschmies S, Bothmann H, Castaldo C, Cocconcelli G, Comery TA, Di L, Dunlop J, Lock T, Kramer A, Kowal D, Jow F, Grauer S, Harrison B, La Rosa S, Maccari L, Marquis KL, Micco I, Nencini A, Quinn J, Robichaud AJ, Roncarati R, Scali C, Terstappen GC, Turlizzi E, Valacchi M, Varrone M, Zanaletti R, Zanelli U.

J Med Chem. 2010 Jun 10;53(11):4379-89. doi: 10.1021/jm901692q.

PMID:
20465311
[PubMed - indexed for MEDLINE]
8.

Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.

Sharples CG, Karig G, Simpson GL, Spencer JA, Wright E, Millar NS, Wonnacott S, Gallagher T.

J Med Chem. 2002 Jul 18;45(15):3235-45.

PMID:
12109907
[PubMed - indexed for MEDLINE]
9.

N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward an α7 nicotinic acetylcholine receptor agonist preclinical candidate.

Zanaletti R, Bettinetti L, Castaldo C, Ceccarelli I, Cocconcelli G, Comery TA, Dunlop J, Genesio E, Ghiron C, Haydar SN, Jow F, Maccari L, Micco I, Nencini A, Pratelli C, Scali C, Turlizzi E, Valacchi M.

J Med Chem. 2012 Nov 26;55(22):10277-81. doi: 10.1021/jm3013568. Epub 2012 Nov 2.

PMID:
23083093
[PubMed - indexed for MEDLINE]
10.

Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic acetylcholine receptor agonists.

Walker DP, Wishka DG, Piotrowski DW, Jia S, Reitz SC, Yates KM, Myers JK, Vetman TN, Margolis BJ, Jacobsen EJ, Acker BA, Groppi VE, Wolfe ML, Thornburgh BA, Tinholt PM, Cortes-Burgos LA, Walters RR, Hester MR, Seest EP, Dolak LA, Han F, Olson BA, Fitzgerald L, Staton BA, Raub TJ, Hajos M, Hoffmann WE, Li KS, Higdon NR, Wall TM, Hurst RS, Wong EH, Rogers BN.

Bioorg Med Chem. 2006 Dec 15;14(24):8219-48. Epub 2006 Oct 2.

PMID:
17011782
[PubMed - indexed for MEDLINE]
11.

Synthesis and structure-activity relationship studies of 3,6-diazabicyclo[3.2.0]heptanes as novel alpha4beta2 nicotinic acetylcholine receptor selective agonists.

Ji J, Schrimpf MR, Sippy KB, Bunnelle WH, Li T, Anderson DJ, Faltynek C, Surowy CS, Dyhring T, Ahring PK, Meyer MD.

J Med Chem. 2007 Nov 1;50(22):5493-508. Epub 2007 Oct 11.

PMID:
17929796
[PubMed - indexed for MEDLINE]
12.

Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.

Bunnelle WH, Tietje KR, Frost JM, Peters D, Ji J, Li T, Scanio MJ, Shi L, Anderson DJ, Dyhring T, Grønlien JH, Ween H, Thorin-Hagene K, Meyer MD.

J Med Chem. 2009 Jul 23;52(14):4126-41. doi: 10.1021/jm900249k.

PMID:
19552432
[PubMed - indexed for MEDLINE]
13.

Virtual screening for alpha7 nicotinic acetylcholine receptor for treatment of Alzheimer's disease.

Chen SG, Gu RX, Dai H, Wei DQ.

J Mol Graph Model. 2013 Feb;39:98-107. doi: 10.1016/j.jmgm.2012.11.008. Epub 2012 Nov 29.

PMID:
23261879
[PubMed - indexed for MEDLINE]
14.

Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists.

Frost JM, Bunnelle WH, Tietje KR, Anderson DJ, Rueter LE, Curzon P, Surowy CS, Ji J, Daanen JF, Kohlhaas KL, Buckley MJ, Henry RF, Dyhring T, Ahring PK, Meyer MD.

J Med Chem. 2006 Dec 28;49(26):7843-53.

PMID:
17181167
[PubMed - indexed for MEDLINE]
15.

SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.

Schrimpf MR, Sippy KB, Briggs CA, Anderson DJ, Li T, Ji J, Frost JM, Surowy CS, Bunnelle WH, Gopalakrishnan M, Meyer MD.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1633-8. doi: 10.1016/j.bmcl.2011.12.126. Epub 2012 Jan 8.

PMID:
22281189
[PubMed - indexed for MEDLINE]
16.

N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors.

Chen J, Norrholm S, Dwoskin LP, Crooks PA, Bai D.

Bioorg Med Chem Lett. 2003 Jan 6;13(1):97-100.

PMID:
12467625
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

7-Azaindole derivatives as potential partial nicotinic agonists.

Stoit AR, den Hartog AP, Mons H, van Schaik S, Barkhuijsen N, Stroomer C, Coolen HK, Reinders JH, Adolfs TJ, van der Neut M, Keizer H, Kruse CG.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):188-93. Epub 2007 Nov 1.

PMID:
18006307
[PubMed - indexed for MEDLINE]
18.

(R)-3'-(3-methylbenzo[b]thiophen-5-yl)spiro[1-azabicyclo[2,2,2]octane-3,5'-oxazolidin]-2'-one, a novel and potent alpha7 nicotinic acetylcholine receptor partial agonist displays cognitive enhancing properties.

Tatsumi R, Fujio M, Takanashi S, Numata A, Katayama J, Satoh H, Shiigi Y, Maeda J, Kuriyama M, Horikawa T, Murozono T, Hashimoto K, Tanaka H.

J Med Chem. 2006 Jul 13;49(14):4374-83.

PMID:
16821797
[PubMed - indexed for MEDLINE]
19.

A novel series of [3.2.1] azabicyclic biaryl ethers as alpha3beta4 and alpha6/4beta4 nicotinic receptor agonists.

Lowe JA 3rd, DeNinno SL, Coe JW, Zhang L, Mente S, Hurst RS, Mather RJ, Ward KM, Shrikhande A, Rollema H, Johnson DE, Horner W, Gorczyca R, Tingley FD 3rd, Kozak R, Majchrzak MJ, Tritto T, Sadlier J, Shaffer CL, Ellerbrock B, Osgood SM, MacDougall MC, McDowell LL.

Bioorg Med Chem Lett. 2010 Aug 15;20(16):4749-52. doi: 10.1016/j.bmcl.2010.06.142.

PMID:
20663668
[PubMed - indexed for MEDLINE]
20.

Synthesis and structure-activity relationship of novel pyridyl ethers for the nicotinic acetylcholine receptor.

Lee J, Davis CB, Rivero RA, Reitz AB, Shank RP.

Bioorg Med Chem Lett. 2000 May 15;10(10):1063-6.

PMID:
10843217
[PubMed - indexed for MEDLINE]
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