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Items: 1 to 20 of 97

1.

Molecular targets and mechanisms of radiosensitization using DNA damage response pathways.

Raleigh DR, Haas-Kogan DA.

Future Oncol. 2013 Feb;9(2):219-33. doi: 10.2217/fon.12.185. Review.

2.

Molecular Pathways: Overcoming Radiation Resistance by Targeting DNA Damage Response Pathways.

Morgan MA, Lawrence TS.

Clin Cancer Res. 2015 Jul 1;21(13):2898-904. doi: 10.1158/1078-0432.CCR-13-3229. Review.

4.

Radioprotection and cell cycle arrest of intestinal epithelial cells by darinaparsin, a tumor radiosensitizer.

Tian J, Doi H, Saar M, Santos J, Li X, Peehl DM, Knox SJ.

Int J Radiat Oncol Biol Phys. 2013 Dec 1;87(5):1179-85. doi: 10.1016/j.ijrobp.2013.08.051. Epub 2013 Oct 24.

PMID:
24210080
5.

Radiation-induced signaling pathways that promote cancer cell survival (review).

Hein AL, Ouellette MM, Yan Y.

Int J Oncol. 2014 Nov;45(5):1813-9. doi: 10.3892/ijo.2014.2614. Epub 2014 Aug 20. Review.

6.

Newly developed strategies for improving sensitivity to radiation by targeting signal pathways in cancer therapy.

Ding M, Zhang E, He R, Wang X.

Cancer Sci. 2013 Nov;104(11):1401-10. doi: 10.1111/cas.12252. Epub 2013 Sep 23. Review.

7.

Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage.

Ha K, Fiskus W, Rao R, Balusu R, Venkannagari S, Nalabothula NR, Bhalla KN.

Mol Cancer Ther. 2011 Jul;10(7):1194-206. doi: 10.1158/1535-7163.MCT-11-0094. Epub 2011 May 12.

8.

The DNA damage response during mitosis.

Heijink AM, Krajewska M, van Vugt MA.

Mutat Res. 2013 Oct;750(1-2):45-55. doi: 10.1016/j.mrfmmm.2013.07.003. Epub 2013 Jul 21. Review.

PMID:
23880065
9.

Signal transduction inhibitors as radiosensitizers.

Tenzer A, Zingg D, Riesterer O, Vuong V, Bodis S, Pruschy M.

Curr Med Chem Anticancer Agents. 2002 Nov;2(6):727-42. Review.

PMID:
12678723
10.

Understanding DNA damage response and DNA repair pathways: applications to more targeted cancer therapeutics.

Kinsella TJ.

Semin Oncol. 2009 Apr;36(2 Suppl 1):S42-51. doi: 10.1053/j.seminoncol.2009.02.004.

PMID:
19393835
11.

Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair.

Wei D, Parsels LA, Karnak D, Davis MA, Parsels JD, Marsh AC, Zhao L, Maybaum J, Lawrence TS, Sun Y, Morgan MA.

Clin Cancer Res. 2013 Aug 15;19(16):4422-32. doi: 10.1158/1078-0432.CCR-13-0788. Epub 2013 Jun 18.

12.

Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor.

Ogiwara H, Ui A, Shiotani B, Zou L, Yasui A, Kohno T.

Carcinogenesis. 2013 Nov;34(11):2486-97. doi: 10.1093/carcin/bgt240. Epub 2013 Jul 3.

13.

In vitro enhancement of tumor cell radiosensitivity by a selective inhibitor of cyclooxygenase-2 enzyme: mechanistic considerations.

Raju U, Nakata E, Yang P, Newman RA, Ang KK, Milas L.

Int J Radiat Oncol Biol Phys. 2002 Nov 1;54(3):886-94.

PMID:
12377342
14.

Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us.

Jeggo PA.

Health Phys. 2009 Nov;97(5):416-25. doi: 10.1097/HP.0b013e3181aff9c8.

PMID:
19820451
15.

ATM as a target for novel radiosensitizers.

Sarkaria JN, Eshleman JS.

Semin Radiat Oncol. 2001 Oct;11(4):316-27. Review.

PMID:
11677656
16.

Targeted radiosensitization by the Chk1 inhibitor SAR-020106.

Borst GR, McLaughlin M, Kyula JN, Neijenhuis S, Khan A, Good J, Zaidi S, Powell NG, Meier P, Collins I, Garrett MD, Verheij M, Harrington KJ.

Int J Radiat Oncol Biol Phys. 2013 Mar 15;85(4):1110-8. doi: 10.1016/j.ijrobp.2012.08.006. Epub 2012 Sep 14.

PMID:
22981708
17.
18.

Garcinol, a histone acetyltransferase inhibitor, radiosensitizes cancer cells by inhibiting non-homologous end joining.

Oike T, Ogiwara H, Torikai K, Nakano T, Yokota J, Kohno T.

Int J Radiat Oncol Biol Phys. 2012 Nov 1;84(3):815-21. doi: 10.1016/j.ijrobp.2012.01.017. Epub 2012 Mar 13.

PMID:
22417805
19.

The DNA damage response: implications for tumor responses to radiation and chemotherapy.

Goldstein M, Kastan MB.

Annu Rev Med. 2015;66:129-43. doi: 10.1146/annurev-med-081313-121208. Epub 2014 Nov 24. Review.

PMID:
25423595
20.

The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization.

Sekhar KR, Reddy YT, Reddy PN, Crooks PA, Venkateswaran A, McDonald WH, Geng L, Sasi S, Van Der Waal RP, Roti JL, Salleng KJ, Rachakonda G, Freeman ML.

Clin Cancer Res. 2011 Oct 15;17(20):6490-9. doi: 10.1158/1078-0432.CCR-11-1054. Epub 2011 Aug 30.

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