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Results: 1 to 20 of 107

1.

Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter.

Cherian C, Kugel Desmoulin S, Wang L, Polin L, White K, Kushner J, Stout M, Hou Z, Gangjee A, Matherly LH.

Cancer Chemother Pharmacol. 2013 Apr;71(4):999-1011. doi: 10.1007/s00280-013-2094-0. Epub 2013 Feb 15.

PMID:
23412628
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter.

Kugel Desmoulin S, Wang L, Hales E, Polin L, White K, Kushner J, Stout M, Hou Z, Cherian C, Gangjee A, Matherly LH.

Mol Pharmacol. 2011 Dec;80(6):1096-107. doi: 10.1124/mol.111.073833. Epub 2011 Sep 22.

PMID:
21940787
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase.

Wang L, Desmoulin SK, Cherian C, Polin L, White K, Kushner J, Fulterer A, Chang MH, Mitchell-Ryan S, Stout M, Romero MF, Hou Z, Matherly LH, Gangjee A.

J Med Chem. 2011 Oct 27;54(20):7150-64. doi: 10.1021/jm200739e. Epub 2011 Sep 22.

PMID:
21879757
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors.

Desmoulin SK, Wang Y, Wu J, Stout M, Hou Z, Fulterer A, Chang MH, Romero MF, Cherian C, Gangjee A, Matherly LH.

Mol Pharmacol. 2010 Oct;78(4):577-87. doi: 10.1124/mol.110.065896. Epub 2010 Jul 2.

PMID:
20601456
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter.

Desmoulin SK, Wang L, Polin L, White K, Kushner J, Stout M, Hou Z, Cherian C, Gangjee A, Matherly LH.

Mol Pharmacol. 2012 Oct;82(4):591-600. Epub 2012 Jun 26.

PMID:
22740639
[PubMed - indexed for MEDLINE]
Free PMC Article
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10.

Novel 5-Substituted Pyrrolo[2,3-d]pyrimidines as Dual Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase and as Potential Antitumor Agents.

Wang Y, Mitchell-Ryan S, Raghavan S, George C, Orr S, Hou Z, Matherly LH, Gangjee A.

J Med Chem. 2015 Jan 20. [Epub ahead of print]

PMID:
25602637
[PubMed - as supplied by publisher]
11.

The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.

Desmoulin SK, Hou Z, Gangjee A, Matherly LH.

Cancer Biol Ther. 2012 Dec;13(14):1355-73. doi: 10.4161/cbt.22020. Epub 2012 Sep 6. Review.

PMID:
22954694
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity.

Deng Y, Wang Y, Cherian C, Hou Z, Buck SA, Matherly LH, Gangjee A.

J Med Chem. 2008 Aug 28;51(16):5052-63. doi: 10.1021/jm8003366. Epub 2008 Aug 5.

PMID:
18680275
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.

Wang Y, Cherian C, Orr S, Mitchell-Ryan S, Hou Z, Raghavan S, Matherly LH, Gangjee A.

J Med Chem. 2013 Nov 14;56(21):8684-95. doi: 10.1021/jm401139z. Epub 2013 Oct 30.

PMID:
24111942
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporter.

Golani LK, George C, Zhao S, Raghavan S, Orr S, Wallace A, Wilson MR, Hou Z, Matherly LH, Gangjee A.

J Med Chem. 2014 Oct 9;57(19):8152-66. doi: 10.1021/jm501113m. Epub 2014 Sep 19.

PMID:
25234128
[PubMed - indexed for MEDLINE]
15.

The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.

Matherly LH, Wilson MR, Hou Z.

Drug Metab Dispos. 2014 Apr;42(4):632-49. doi: 10.1124/dmd.113.055723. Epub 2014 Jan 6. Review.

PMID:
24396145
[PubMed - indexed for MEDLINE]
16.

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.

Shih C, Chen VJ, Gossett LS, Gates SB, MacKellar WC, Habeck LL, Shackelford KA, Mendelsohn LG, Soose DJ, Patel VF, Andis SL, Bewley JR, Rayl EA, Moroson BA, Beardsley GP, Kohler W, Ratnam M, Schultz RM.

Cancer Res. 1997 Mar 15;57(6):1116-23.

PMID:
9067281
[PubMed - indexed for MEDLINE]
Free Article
17.

Biology of the major facilitative folate transporters SLC19A1 and SLC46A1.

Hou Z, Matherly LH.

Curr Top Membr. 2014;73:175-204. doi: 10.1016/B978-0-12-800223-0.00004-9. Review.

PMID:
24745983
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo.

Mauritz R, Peters GJ, Kathmann I, Teshale H, Noordhuis P, Comijn EM, Pinedo HM, Jansen G.

Cancer Chemother Pharmacol. 2008 Nov;62(6):937-48. doi: 10.1007/s00280-008-0683-0. Epub 2008 Feb 19.

PMID:
18283461
[PubMed - indexed for MEDLINE]
19.

Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.

Rhee MS, Galivan J, Wright JE, Rosowsky A.

Mol Pharmacol. 1994 Apr;45(4):783-91.

PMID:
7514264
[PubMed - indexed for MEDLINE]
20.

The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.

Zhao R, Qiu A, Tsai E, Jansen M, Akabas MH, Goldman ID.

Mol Pharmacol. 2008 Sep;74(3):854-62. doi: 10.1124/mol.108.045443. Epub 2008 Jun 4.

PMID:
18524888
[PubMed - indexed for MEDLINE]
Free PMC Article

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