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Differential roles of Hath1, MUC2 and P27Kip1 in relation with gamma-secretase inhibition in human colonic carcinomas: a translational study.

Souazé F, Bou-Hanna C, Kandel C, Leclair F, Devallière J, Charreau B, Bézieau S, Mosnier JF, Laboisse CL.

PLoS One. 2013;8(2):e55904. doi: 10.1371/journal.pone.0055904. Epub 2013 Feb 11.


Suppression of mucin 2 promotes interleukin-6 secretion and tumor growth in an orthotopic immune-competent colon cancer animal model.

Shan YS, Hsu HP, Lai MD, Yen MC, Fang JH, Weng TY, Chen YL.

Oncol Rep. 2014 Dec;32(6):2335-42. doi: 10.3892/or.2014.3544. Epub 2014 Oct 13.


Effects of monochromatic light stimuli on the development and Muc2 expression of goblet cells in broiler small intestines during embryogenesis.

Yu Y, Wang Z, Cao J, Dong Y, Wang T, Chen Y.

Poult Sci. 2014 Jul;93(7):1801-8. doi: 10.3382/ps.2013-03805. Epub 2014 May 26.


Inductive differentiation of conjunctival goblet cells by γ-secretase inhibitor and construction of recombinant conjunctival epithelium.

Tian L, Qu M, Wang Y, Duan H, Di G, Xie L, Zhou Q.

Exp Eye Res. 2014 Jun;123:37-42. doi: 10.1016/j.exer.2014.04.001. Epub 2014 Apr 16.


Inhibition of gamma-secretase activity impedes uterine serous carcinoma growth in a human xenograft model.

Groeneweg JW, Hall TR, Zhang L, Kim M, Byron VF, Tambouret R, Sathayanrayanan S, Foster R, Rueda BR, Growdon WB.

Gynecol Oncol. 2014 Jun;133(3):607-15. doi: 10.1016/j.ygyno.2014.03.560. Epub 2014 Mar 22.


Differentiation- and apoptosis-inducing activities of rice bran extracts in a human colon cancer cell line.

Takashima A, Ohtomo M, Kikuchi T, Iwashita J, Abe T, Hata K.

J Food Sci Technol. 2013 Jun;50(3):595-9. doi: 10.1007/s13197-011-0368-2. Epub 2011 Apr 19.


Development of intestinal organoids as tissue surrogates: cell composition and the epigenetic control of differentiation.

Cao L, Kuratnik A, Xu W, Gibson JD, Kolling F 4th, Falcone ER, Ammar M, Van Heyst MD, Wright DL, Nelson CE, Giardina C.

Mol Carcinog. 2015 Mar;54(3):189-202. doi: 10.1002/mc.22089. Epub 2013 Sep 21.


Intermittent oral coadministration of a gamma secretase inhibitor with dexamethasone mitigates intestinal goblet cell hyperplasia in rats.

Aguirre SA, Liu L, Hosea NA, Scott W, May JR, Burns-Naas LA, Randolph S, Denlinger RH, Han B.

Toxicol Pathol. 2014;42(2):422-34. doi: 10.1177/0192623313486315. Epub 2013 May 7.


FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density.

Qi W, Fitchev PS, Cornwell ML, Greenberg J, Cabe M, Weber CR, Roy HK, Crawford SE, Savkovic SD.

J Biol Chem. 2013 Jun 7;288(23):16274-81. doi: 10.1074/jbc.M113.470617. Epub 2013 Apr 18.


The role of Notch and gamma-secretase inhibition in an ovarian cancer model.

Shah MM, Zerlin M, Li BY, Herzog TJ, Kitajewski JK, Wright JD.

Anticancer Res. 2013 Mar;33(3):801-8.


[Role of MUC2 gene in the regulation of rat intestinal barrier function by probiotics].

Yu J, Hao X, Long M, Wang Q, Qu Y, Wen Y, Zhang W, Luo J, Cao H.

Nan Fang Yi Ke Da Xue Xue Bao. 2013 Feb;33(2):197-201. Chinese.


Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo.

Becker S, Oelschlaeger TA, Wullaert A, Vlantis K, Pasparakis M, Wehkamp J, Stange EF, Gersemann M.

PLoS One. 2013;8(2):e55620. doi: 10.1371/journal.pone.0055620. Epub 2013 Feb 13. Erratum in: PLoS One. 2013;8(5). doi:10.1371/annotation/13f3d7ee-a72c-4879-bedb-8e73b6b364ac. Vlantis, Katerina [added].


The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein.

Kano Y, Tsuchiya K, Zheng X, Horita N, Fukushima K, Hibiya S, Yamauchi Y, Nishimura T, Hinohara K, Gotoh N, Suzuki S, Okamoto R, Nakamura T, Watanabe M.

Biochem Biophys Res Commun. 2013 Mar 1;432(1):175-81. doi: 10.1016/j.bbrc.2013.01.034. Epub 2013 Jan 16.


Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK.

Maraver A, Fernandez-Marcos PJ, Herranz D, Cañamero M, Muñoz-Martin M, Gómez-López G, Mulero F, Megías D, Sanchez-Carbayo M, Shen J, Sanchez-Cespedes M, Palomero T, Ferrando A, Serrano M.

Cancer Cell. 2012 Aug 14;22(2):222-34. doi: 10.1016/j.ccr.2012.06.014.


H. pylori induces the expression of Hath1 in gastric epithelial cells via interleukin-8/STAT3 phosphorylation while suppressing Hes1.

Zhang X, Yang Y, Zhu R, Bai J, Tian Y, Li X, Peng Z, He Y, Chen L, Fang D, Chen W, Zou Q, Mao X, Wang R.

J Cell Biochem. 2012 Dec;113(12):3740-51. doi: 10.1002/jcb.24248.


Repeated exposure to water immersion stress reduces the Muc2 gene level in the rat colon via two distinct mechanisms.

Shigeshiro M, Tanabe S, Suzuki T.

Brain Behav Immun. 2012 Oct;26(7):1061-5. doi: 10.1016/j.bbi.2012.05.016. Epub 2012 Jun 6.


Over-expression of BMPR-IB reduces the malignancy of glioblastoma cells by upregulation of p21 and p27Kip1.

Liu S, Yin F, Fan W, Wang S, Guo XR, Zhang JN, Tian ZM, Fan M.

J Exp Clin Cancer Res. 2012 May 31;31:52. doi: 10.1186/1756-9966-31-52.


Histamine regulates mucin expression through H1 receptor in airway epithelial cells.

Kim HM, Lee CH, Rhee CS.

Acta Otolaryngol. 2012 Jun;132 Suppl 1:S37-43. doi: 10.3109/00016489.2012.661075.


GSI-I has a better effect in inhibiting hepatocellular carcinoma cell growth than GSI-IX, GSI-X, or GSI-XXI.

Shen Y, Lv D, Wang J, Yin Y, Miao F, Dou F, Zhang J.

Anticancer Drugs. 2012 Aug;23(7):683-90. doi: 10.1097/CAD.0b013e3283549a22.

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