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Results: 1 to 20 of 96

1.

New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition.

Alvarez G, Martínez J, Aguirre-López B, Cabrera N, Pérez-Díaz L, de Gómez-Puyou MT, Gómez-Puyou A, Pérez-Montfort R, Garat B, Merlino A, González M, Cerecetto H.

J Enzyme Inhib Med Chem. 2014 Apr;29(2):198-204. doi: 10.3109/14756366.2013.765415. Epub 2013 Feb 13.

PMID:
23406473
[PubMed - in process]
2.

1,2,4-thiadiazol-5(4H)-ones: a new class of selective inhibitors of Trypanosoma cruzi triosephosphate isomerase. Study of the mechanism of inhibition.

Alvarez G, Aguirre-López B, Cabrera N, Marins EB, Tinoco L, Batthyány CI, de Gómez-Puyou MT, Puyou AG, Pérez-Montfort R, Cerecetto H, González M.

J Enzyme Inhib Med Chem. 2013 Oct;28(5):981-9. doi: 10.3109/14756366.2012.700928. Epub 2012 Jul 18.

PMID:
22803666
[PubMed - indexed for MEDLINE]
3.

Inactivation of triosephosphate isomerase from Trypanosoma cruzi by an agent that perturbs its dimer interface.

Téllez-Valencia A, Olivares-Illana V, Hernández-Santoyo A, Pérez-Montfort R, Costas M, Rodríguez-Romero A, López-Calahorra F, Tuena De Gómez-Puyou M, Gómez-Puyou A.

J Mol Biol. 2004 Aug 27;341(5):1355-65.

PMID:
15321726
[PubMed - indexed for MEDLINE]
4.

Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity.

Alvarez G, Aguirre-López B, Varela J, Cabrera M, Merlino A, López GV, Lavaggi ML, Porcal W, Di Maio R, González M, Cerecetto H, Cabrera N, Pérez-Montfort R, de Gómez-Puyou MT, Gómez-Puyou A.

Eur J Med Chem. 2010 Dec;45(12):5767-72. doi: 10.1016/j.ejmech.2010.09.034. Epub 2010 Sep 19.

PMID:
20889239
[PubMed - indexed for MEDLINE]
5.

Perturbation of the dimer interface of triosephosphate isomerase and its effect on Trypanosoma cruzi.

Olivares-Illana V, Rodríguez-Romero A, Becker I, Berzunza M, García J, Pérez-Montfort R, Cabrera N, López-Calahorra F, de Gómez-Puyou MT, Gómez-Puyou A.

PLoS Negl Trop Dis. 2007 Oct 31;1(1):e1.

PMID:
17989778
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Highly specific inactivation of triosephosphate isomerase from Trypanosoma cruzi.

Téllez-Valencia A, Avila-Ríos S, Pérez-Montfort R, Rodríguez-Romero A, Tuena de Gómez-Puyou M, López-Calahorra F, Gómez-Puyou A.

Biochem Biophys Res Commun. 2002 Jul 26;295(4):958-63.

PMID:
12127988
[PubMed - indexed for MEDLINE]
7.

Selective inactivation of triosephosphate isomerase from Trypanosoma cruzi by brevifolin carboxylate derivatives isolated from Geranium bellum Rose.

Gayosso-De-Lucio J, Torres-Valencia M, Rojo-Domínguez A, Nájera-Peña H, Aguirre-López B, Salas-Pacheco J, Avitia-Domínguez C, Téllez-Valencia A.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5936-9. doi: 10.1016/j.bmcl.2009.08.055. Epub 2009 Aug 20.

PMID:
19733070
[PubMed - indexed for MEDLINE]
8.

Differences in the intersubunit contacts in triosephosphate isomerase from two closely related pathogenic trypanosomes.

Maldonado E, Soriano-García M, Moreno A, Cabrera N, Garza-Ramos G, de Gómez-Puyou M, Gómez-Puyou A, Perez-Montfort R.

J Mol Biol. 1998;283(1):193-203.

PMID:
9761683
[PubMed - indexed for MEDLINE]
9.

Factors that control the reactivity of the interface cysteine of triosephosphate isomerase from Trypanosoma brucei and Trypanosoma cruzi.

Reyes-Vivas H, Hernández-Alcantara G, López-Velazquez G, Cabrera N, Pérez-Montfort R, de Gómez-Puyou MT, Gómez-Puyou A.

Biochemistry. 2001 Mar 13;40(10):3134-40.

PMID:
11258928
[PubMed - indexed for MEDLINE]
10.

Sulfhydryl reagent susceptibility in proteins with high sequence similarity--triosephosphate isomerase from Trypanosoma brucei, Trypanosoma cruzi and Leishmania mexicana.

Garza-Ramos G, Cabrera N, Saavedra-Lira E, Tuena de Gómez-Puyou M, Ostoa-Saloma P, Pérez-Montfort R, Gómez-Puyou A.

Eur J Biochem. 1998 May 1;253(3):684-91.

PMID:
9654066
[PubMed - indexed for MEDLINE]
Free Article
11.

Structural differences in triosephosphate isomerase from different species and discovery of a multitrypanosomatid inhibitor.

Olivares-Illana V, Pérez-Montfort R, López-Calahorra F, Costas M, Rodríguez-Romero A, Tuena de Gómez-Puyou M, Gómez Puyou A.

Biochemistry. 2006 Feb 28;45(8):2556-60.

PMID:
16489748
[PubMed - indexed for MEDLINE]
12.

Crosstalk between the subunits of the homodimeric enzyme triosephosphate isomerase.

Zomosa-Signoret V, Aguirre-López B, Hernández-Alcántara G, Pérez-Montfort R, de Gómez-Puyou MT, Gómez-Puyou A.

Proteins. 2007 Apr 1;67(1):75-83.

PMID:
17221869
[PubMed - indexed for MEDLINE]
13.

The design and inhibitory profile of new benzimidazole derivatives against triosephosphate isomerase from Trypanosoma cruzi: a problem of residue motility.

Romo-Mancillas A, Téllez-Valencia A, Yépez-Mulia L, Hernández-Luis F, Hernández-Campos A, Castillo R.

J Mol Graph Model. 2011 Sep;30:90-9. doi: 10.1016/j.jmgm.2011.06.009. Epub 2011 Jun 29.

PMID:
21798779
[PubMed - indexed for MEDLINE]
14.

A monoclonal antibody that inhibits Trypanosoma cruzi growth in vitro and its reaction with intracellular triosephosphate isomerase.

Cortés-Figueroa AA, Pérez-Torres A, Salaiza N, Cabrera N, Escalona-Montaño A, Rondán A, Aguirre-García M, Gómez-Puyou A, Pérez-Montfort R, Becker I.

Parasitol Res. 2008 Mar;102(4):635-43. Epub 2007 Nov 29.

PMID:
18046577
[PubMed - indexed for MEDLINE]
15.

Control of the reactivation kinetics of homodimeric triosephosphate isomerase from unfolded monomers.

Zomosa-Signoret V, Hernández-Alcántara G, Reyes-Vivas H, Martínez-Martínez E, Garza-Ramos G, Pérez-Montfort R, Tuena De Gómez-Puyou M, Gómez-Puyou A.

Biochemistry. 2003 Mar 25;42(11):3311-8.

PMID:
12641463
[PubMed - indexed for MEDLINE]
16.

Cloning, expression, purification and characterization of triosephosphate isomerase from Trypanosoma cruzi.

Ostoa-Saloma P, Garza-Ramos G, Ramírez J, Becker I, Berzunza M, Landa A, Gómez-Puyou A, Tuena de Gómez-Puyou M, Pérez-Montfort R.

Eur J Biochem. 1997 Mar 15;244(3):700-5.

PMID:
9108237
[PubMed - indexed for MEDLINE]
Free Article
17.

Reversible equilibrium unfolding of triosephosphate isomerase from Trypanosoma cruzi in guanidinium hydrochloride involves stable dimeric and monomeric intermediates.

Chánez-Cárdenas ME, Pérez-Hernández G, Sánchez-Rebollar BG, Costas M, Vázquez-Contreras E.

Biochemistry. 2005 Aug 16;44(32):10883-92.

PMID:
16086591
[PubMed - indexed for MEDLINE]
18.

Derivatization of the interface cysteine of triosephosphate isomerase from Trypanosoma brucei and Trypanosoma cruzi as probe of the interrelationship between the catalytic sites and the dimer interface.

Pérez-Montfort R, Garza-Ramos G, Alcántara GH, Reyes-Vivas H, Gao XG, Maldonado E, de Gómez-Puyou MT, Gómez-Puyou A.

Biochemistry. 1999 Mar 30;38(13):4114-20.

PMID:
10194326
[PubMed - indexed for MEDLINE]
19.

Susceptibility to proteolysis of triosephosphate isomerase from two pathogenic parasites: characterization of an enzyme with an intact and a nicked monomer.

Reyes-Vivas H, Martínez-Martínez E, Mendoza-Hernández G, López-Velázquez G, Pérez-Montfort R, Tuena de Gómez-Puyou M, Gómez-Puyou A.

Proteins. 2002 Aug 15;48(3):580-90.

PMID:
12112681
[PubMed - indexed for MEDLINE]
20.

Structural considerations for the rational design of selective anti-trypanosomal agents: the role of the aromatic clusters at the interface of triosephosphate isomerase dimer.

Espinoza-Fonseca LM, Trujillo-Ferrara JG.

Biochem Biophys Res Commun. 2005 Mar 25;328(4):922-8.

PMID:
15707966
[PubMed - indexed for MEDLINE]

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