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Items: 1 to 20 of 175

1.

Rules that govern UPF1 binding to mRNA 3' UTRs.

Kurosaki T, Maquat LE.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3357-62. doi: 10.1073/pnas.1219908110. Epub 2013 Feb 12.

2.

Evidence that the Upf1-related molecular motor scans the 3'-UTR to ensure mRNA integrity.

Shigeoka T, Kato S, Kawaichi M, Ishida Y.

Nucleic Acids Res. 2012 Aug;40(14):6887-97. doi: 10.1093/nar/gks344. Epub 2012 May 2.

3.

Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.

Kashima I, Yamashita A, Izumi N, Kataoka N, Morishita R, Hoshino S, Ohno M, Dreyfuss G, Ohno S.

Genes Dev. 2006 Feb 1;20(3):355-67.

4.

A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay.

Singh G, Rebbapragada I, Lykke-Andersen J.

PLoS Biol. 2008 Apr 29;6(4):e111. doi: 10.1371/journal.pbio.0060111.

5.

Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways.

Metze S, Herzog VA, Ruepp MD, Mühlemann O.

RNA. 2013 Oct;19(10):1432-48. doi: 10.1261/rna.038893.113. Epub 2013 Aug 20.

6.

CK2-mediated TEL2 phosphorylation augments nonsense-mediated mRNA decay (NMD) by increase of SMG1 stability.

Ahn S, Kim J, Hwang J.

Biochim Biophys Acta. 2013 Oct;1829(10):1047-55. doi: 10.1016/j.bbagrm.2013.06.002. Epub 2013 Jul 3.

7.

Upf1/Upf2 regulation of 3' untranslated region splice variants of AUF1 links nonsense-mediated and A+U-rich element-mediated mRNA decay.

Banihashemi L, Wilson GM, Das N, Brewer G.

Mol Cell Biol. 2006 Dec;26(23):8743-54. Epub 2006 Sep 25.

8.

Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay.

McGlincy NJ, Tan LY, Paul N, Zavolan M, Lilley KS, Smith CW.

BMC Genomics. 2010 Oct 14;11:565. doi: 10.1186/1471-2164-11-565.

9.

A post-translational regulatory switch on UPF1 controls targeted mRNA degradation.

Kurosaki T, Li W, Hoque M, Popp MW, Ermolenko DN, Tian B, Maquat LE.

Genes Dev. 2014 Sep 1;28(17):1900-16. doi: 10.1101/gad.245506.114.

10.

Global analyses of UPF1 binding and function reveal expanded scope of nonsense-mediated mRNA decay.

Hurt JA, Robertson AD, Burge CB.

Genome Res. 2013 Oct;23(10):1636-50. doi: 10.1101/gr.157354.113. Epub 2013 Jun 13.

11.

Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay.

Kim YK, Furic L, Desgroseillers L, Maquat LE.

Cell. 2005 Jan 28;120(2):195-208.

12.

EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length.

Bühler M, Steiner S, Mohn F, Paillusson A, Mühlemann O.

Nat Struct Mol Biol. 2006 May;13(5):462-4. Epub 2006 Apr 23.

PMID:
16622410
13.

The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.

Melero R, Buchwald G, Castaño R, Raabe M, Gil D, Lázaro M, Urlaub H, Conti E, Llorca O.

Nat Struct Mol Biol. 2012 Apr 22;19(5):498-505, S1-2. doi: 10.1038/nsmb.2287.

PMID:
22522823
14.

Transcripts expressed using a bicistronic vector pIREShyg2 are sensitized to nonsense-mediated mRNA decay.

Shikama Y, Hu H, Ohno M, Matsuoka I, Shichishima T, Kimura J.

BMC Mol Biol. 2010 Jun 1;11:42. doi: 10.1186/1471-2199-11-42.

15.

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways.

Ivanov PV, Gehring NH, Kunz JB, Hentze MW, Kulozik AE.

EMBO J. 2008 Mar 5;27(5):736-47. doi: 10.1038/emboj.2008.17. Epub 2008 Feb 7.

16.

Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs.

Zünd D, Gruber AR, Zavolan M, Mühlemann O.

Nat Struct Mol Biol. 2013 Aug;20(8):936-43. doi: 10.1038/nsmb.2635. Epub 2013 Jul 7.

PMID:
23832275
17.

Both introns and long 3'-UTRs operate as cis-acting elements to trigger nonsense-mediated decay in plants.

Kertész S, Kerényi Z, Mérai Z, Bartos I, Pálfy T, Barta E, Silhavy D.

Nucleic Acids Res. 2006;34(21):6147-57. Epub 2006 Nov 6.

18.

A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay.

Behm-Ansmant I, Gatfield D, Rehwinkel J, Hilgers V, Izaurralde E.

EMBO J. 2007 Mar 21;26(6):1591-601. Epub 2007 Feb 22.

19.

Identification of elements in human long 3' UTRs that inhibit nonsense-mediated decay.

Toma KG, Rebbapragada I, Durand S, Lykke-Andersen J.

RNA. 2015 May;21(5):887-97. doi: 10.1261/rna.048637.114. Epub 2015 Mar 24.

20.

Control of mRNA Stability in Fungi by NMD, EJC and CBC Factors Through 3'UTR Introns.

Zhang Y, Sachs MS.

Genetics. 2015 Aug;200(4):1133-48. doi: 10.1534/genetics.115.176743. Epub 2015 Jun 4.

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