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Items: 1 to 20 of 76

1.

Hh signaling inhibitors from Vitex negundo; naturally occurring inhibitors of the GLI1-DNA complex.

Arai MA, Fujimatsu T, Uchida K, Sadhu SK, Ahmed F, Ishibashi M.

Mol Biosyst. 2013 May;9(5):1012-8. doi: 10.1039/c3mb25567k.

PMID:
23403897
2.

Hedgehog inhibitors from Artocarpus communis and Hyptis suaveolens.

Arai MA, Uchida K, Sadhu SK, Ahmed F, Koyano T, Kowithayakorn T, Ishibashi M.

Bioorg Med Chem. 2015 Aug 1;23(15):4150-4. doi: 10.1016/j.bmc.2015.06.058. Epub 2015 Jul 2.

PMID:
26178912
3.

Physalin H from Solanum nigrum as an Hh signaling inhibitor blocks GLI1-DNA-complex formation.

Arai MA, Uchida K, Sadhu SK, Ahmed F, Ishibashi M.

Beilstein J Org Chem. 2014 Jan 13;10:134-40. doi: 10.3762/bjoc.10.10. eCollection 2014 Jan 13.

4.

New hedgehog/GLI-signaling inhibitors from Adenium obesum.

Arai MA, Tateno C, Koyano T, Kowithayakorn T, Kawabe S, Ishibashi M.

Org Biomol Chem. 2011 Feb 21;9(4):1133-9. doi: 10.1039/c0ob00677g. Epub 2010 Dec 20.

PMID:
21170436
5.

New Hedgehog/GLI signaling inhibitors from Excoecaria agallocha.

Rifai Y, Arai MA, Sadhu SK, Ahmed F, Ishibashi M.

Bioorg Med Chem Lett. 2011 Jan 15;21(2):718-22. doi: 10.1016/j.bmcl.2010.11.126. Epub 2010 Dec 5.

PMID:
21190854
6.

Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells.

Ray A, Meng E, Reed E, Shevde LA, Rocconi RP.

Int J Oncol. 2011 Oct;39(4):797-804. doi: 10.3892/ijo.2011.1093. Epub 2011 Jun 22.

PMID:
21701772
7.

Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription.

Hosoya T, Arai MA, Koyano T, Kowithayakorn T, Ishibashi M.

Chembiochem. 2008 May 5;9(7):1082-92. doi: 10.1002/cbic.200700511.

PMID:
18357592
8.

Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana.

Arai MA, Tateno C, Hosoya T, Koyano T, Kowithayakorn T, Ishibashi M.

Bioorg Med Chem. 2008 Nov 1;16(21):9420-4. doi: 10.1016/j.bmc.2008.09.053. Epub 2008 Sep 24.

PMID:
18842418
9.

Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro.

Wu JY, Xu XF, Xu L, Niu PQ, Wang F, Hu GY, Wang XP, Guo CY.

Hepatogastroenterology. 2011 Sep-Oct;58(110-111):1511-8. doi: 10.5754/hge10765. Epub 2011 Jul 15.

PMID:
21940310
10.

Detection of canonical hedgehog signaling in breast cancer by 131-iodine-labeled derivatives of the sonic hedgehog protein.

Sims-Mourtada J, Yang D, Tworowska I, Larson R, Smith D, Tsao N, Opdenaker L, Mourtada F, Woodward W.

J Biomed Biotechnol. 2012;2012:639562. doi: 10.1155/2012/639562. Epub 2012 Jun 28.

11.

Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2.

Abe Y, Oda-Sato E, Tobiume K, Kawauchi K, Taya Y, Okamoto K, Oren M, Tanaka N.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4838-43. doi: 10.1073/pnas.0712216105. Epub 2008 Mar 21.

12.

Hedgehog signaling promotes medulloblastoma survival via Bc/II.

Bar EE, Chaudhry A, Farah MH, Eberhart CG.

Am J Pathol. 2007 Jan;170(1):347-55.

13.

Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.

Cohen JR, Resnick DZ, Niewiadomski P, Dong H, Liau LM, Waschek JA.

BMC Cancer. 2010 Dec 9;10:676. doi: 10.1186/1471-2407-10-676.

14.

Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway.

Büttner A, Seifert K, Cottin T, Sarli V, Tzagkaroulaki L, Scholz S, Giannis A.

Bioorg Med Chem. 2009 Jul 15;17(14):4943-54. doi: 10.1016/j.bmc.2009.06.008. Epub 2009 Jun 10.

PMID:
19541490
15.

Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines.

Mizuarai S, Kawagishi A, Kotani H.

Mol Cancer. 2009 Jul 6;8:44. doi: 10.1186/1476-4598-8-44.

16.

Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation.

Uhmann A, Niemann H, Lammering B, Henkel C, Hess I, Nitzki F, Fritsch A, Prüfer N, Rosenberger A, Dullin C, Schraepler A, Reifenberger J, Schweyer S, Pietsch T, Strutz F, Schulz-Schaeffer W, Hahn H.

Mol Cancer Ther. 2011 Nov;10(11):2179-88. doi: 10.1158/1535-7163.MCT-11-0422. Epub 2011 Aug 30.

17.

Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL.

Decker S, Zirlik K, Djebatchie L, Hartmann D, Ihorst G, Schmitt-Graeff A, Herchenbach D, Jumaa H, Warmuth M, Veelken H, Dierks C.

Blood. 2012 Jan 26;119(4):997-1007. doi: 10.1182/blood-2011-06-359075. Epub 2011 Nov 30.

18.

Targeting the hedgehog signaling pathway with interacting peptides to Patched-1.

Nakamura M, Tanaka H, Nagayoshi Y, Nakashima H, Tsutsumi K, Ohtsuka T, Takahata S, Tanaka M, Okada H.

J Gastroenterol. 2012 Apr;47(4):452-60. doi: 10.1007/s00535-011-0507-6. Epub 2011 Dec 15.

PMID:
22170414
19.

Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo.

Dennler S, André J, Alexaki I, Li A, Magnaldo T, ten Dijke P, Wang XJ, Verrecchia F, Mauviel A.

Cancer Res. 2007 Jul 15;67(14):6981-6.

20.

Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation.

Liao X, Siu MK, Au CW, Wong ES, Chan HY, Ip PP, Ngan HY, Cheung AN.

Carcinogenesis. 2009 Jan;30(1):131-40. doi: 10.1093/carcin/bgn230. Epub 2008 Nov 20.

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