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Items: 1 to 20 of 88

1.

Targeting chromatin readers.

James LI, Frye SV.

Clin Pharmacol Ther. 2013 Apr;93(4):312-4. doi: 10.1038/clpt.2013.6. Epub 2013 Jan 17. Review.

2.

Drugging Chromatin in Cancer: Recent Advances and Novel Approaches.

Cai SF, Chen CW, Armstrong SA.

Mol Cell. 2015 Nov 19;60(4):561-70. doi: 10.1016/j.molcel.2015.10.042. Review.

PMID:
26590715
3.

Targeting epigenetic regulators for cancer therapy.

Wee S, Dhanak D, Li H, Armstrong SA, Copeland RA, Sims R, Baylin SB, Liu XS, Schweizer L.

Ann N Y Acad Sci. 2014 Feb;1309:30-6. doi: 10.1111/nyas.12356. Review.

PMID:
24571255
4.

Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin.

Robertson JC, Hurley NC, Tortorici M, Ciossani G, Borrello MT, Vellore NA, Ganesan A, Mattevi A, Baron R.

PLoS Comput Biol. 2013;9(7):e1003158. doi: 10.1371/journal.pcbi.1003158. Epub 2013 Jul 18.

5.

Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

Vermeulen M, Eberl HC, Matarese F, Marks H, Denissov S, Butter F, Lee KK, Olsen JV, Hyman AA, Stunnenberg HG, Mann M.

Cell. 2010 Sep 17;142(6):967-80. doi: 10.1016/j.cell.2010.08.020.

6.

Targeting protein-protein interaction by small molecules.

Jin L, Wang W, Fang G.

Annu Rev Pharmacol Toxicol. 2014;54:435-56. doi: 10.1146/annurev-pharmtox-011613-140028. Epub 2013 Oct 21. Review.

PMID:
24160698
7.

Sensing core histone phosphorylation - a matter of perfect timing.

Sawicka A, Seiser C.

Biochim Biophys Acta. 2014 Aug;1839(8):711-8. doi: 10.1016/j.bbagrm.2014.04.013. Epub 2014 Apr 18. Review.

8.

[Targeted epigenetic therapy of cancer. Achievements and perspectives].

Valdespino-Gómez VM, Valdespino-Castillo VE.

Cir Cir. 2012 Sep-Oct;80(5):470-80. Review. Spanish.

PMID:
23351455
9.

Chromatin proteins and modifications as drug targets.

Helin K, Dhanak D.

Nature. 2013 Oct 24;502(7472):480-8. doi: 10.1038/nature12751. Review.

PMID:
24153301
10.

Epigenetic drugs for Alzheimer's disease: hopes and challenges.

Caraci F, Leggio GM, Drago F, Salomone S.

Br J Clin Pharmacol. 2013 Apr;75(4):1154-5. doi: 10.1111/j.1365-2125.2012.04443.x. No abstract available.

11.

Epigenetic drugs for Alzheimer's disease.

Peedicayil J.

Br J Clin Pharmacol. 2013 Apr;75(4):1152-3. doi: 10.1111/j.1365-2125.2012.04444.x. No abstract available.

12.

Targeting epigenetic networks with polypharmacology: a new avenue to tackle cancer.

Franci G, Miceli M, Altucci L.

Epigenomics. 2010 Dec;2(6):731-42. doi: 10.2217/epi.10.62. Review.

PMID:
22122079
13.

Targeting epigenetics in nervous system disease.

Zhang R, Lu J, Kong X, Jin L, Luo C.

CNS Neurol Disord Drug Targets. 2013 Feb 1;12(1):126-41. Review.

PMID:
23244434
14.

Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1.

Law JA, Du J, Hale CJ, Feng S, Krajewski K, Palanca AM, Strahl BD, Patel DJ, Jacobsen SE.

Nature. 2013 Jun 20;498(7454):385-9. doi: 10.1038/nature12178. Epub 2013 May 1.

15.

Chromatin as a target for the DNA-binding anticancer drugs.

Majumder P, Pradhan SK, Devi PG, Pal S, Dasgupta D.

Subcell Biochem. 2007;41:145-89. Review.

PMID:
17484128
16.

Bromodomains: pockets with therapeutic potential.

Papavassiliou KA, Papavassiliou AG.

Trends Mol Med. 2014 Sep;20(9):477-8. doi: 10.1016/j.molmed.2014.06.004. Epub 2014 Jun 28.

PMID:
24986769
17.

PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.

Baker LA, Allis CD, Wang GG.

Mutat Res. 2008 Dec 1;647(1-2):3-12. doi: 10.1016/j.mrfmmm.2008.07.004. Epub 2008 Jul 17. Review.

18.

Chromatin modifiers and the promise of epigenetic therapy in acute leukemia.

Greenblatt SM, Nimer SD.

Leukemia. 2014 Jul;28(7):1396-406. doi: 10.1038/leu.2014.94. Epub 2014 Mar 10. Review.

PMID:
24609046
19.

Mind the methyl: methyllysine binding proteins in epigenetic regulation.

Wagner T, Robaa D, Sippl W, Jung M.

ChemMedChem. 2014 Mar;9(3):466-83. doi: 10.1002/cmdc.201300422. Epub 2014 Jan 21. Review.

PMID:
24449612
20.

Targeting epigenetic mediators of gene expression in thoracic malignancies.

Schrump DS.

Biochim Biophys Acta. 2012 Jul;1819(7):836-45. doi: 10.1016/j.bbagrm.2012.03.009. Epub 2012 Apr 9. Review.

PMID:
22507242
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