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Results: 1 to 20 of 99

1.

Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model.

Peng CX, Hu J, Liu D, Hong XP, Wu YY, Zhu LQ, Wang JZ.

Neurobiol Aging. 2013 Jun;34(6):1555-63. doi: 10.1016/j.neurobiolaging.2012.12.010. Epub 2013 Feb 10.

PMID:
23402899
[PubMed - indexed for MEDLINE]
2.

A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo.

Serenó L, Coma M, Rodríguez M, Sánchez-Ferrer P, Sánchez MB, Gich I, Agulló JM, Pérez M, Avila J, Guardia-Laguarta C, Clarimón J, Lleó A, Gómez-Isla T.

Neurobiol Dis. 2009 Sep;35(3):359-67. doi: 10.1016/j.nbd.2009.05.025. Epub 2009 Jun 10.

PMID:
19523516
[PubMed - indexed for MEDLINE]
3.

Glycogen synthase kinase-3 (GSK-3) inhibitors for the treatment of Alzheimer's disease.

Medina M, Avila J.

Curr Pharm Des. 2010;16(25):2790-8. Review.

PMID:
20698823
[PubMed - indexed for MEDLINE]
4.

Role of glycogen synthase kinase-3 in Alzheimer's disease pathogenesis and glycogen synthase kinase-3 inhibitors.

Avila J, Wandosell F, Hernández F.

Expert Rev Neurother. 2010 May;10(5):703-10. doi: 10.1586/ern.10.40.

PMID:
20420491
[PubMed - indexed for MEDLINE]
5.

A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer's disease.

Onishi T, Iwashita H, Uno Y, Kunitomo J, Saitoh M, Kimura E, Fujita H, Uchiyama N, Kori M, Takizawa M.

J Neurochem. 2011 Dec;119(6):1330-40. doi: 10.1111/j.1471-4159.2011.07532.x. Epub 2011 Nov 2.

PMID:
21992552
[PubMed - indexed for MEDLINE]
6.

Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.

Hurtado DE, Molina-Porcel L, Carroll JC, Macdonald C, Aboagye AK, Trojanowski JQ, Lee VM.

J Neurosci. 2012 May 23;32(21):7392-402. doi: 10.1523/JNEUROSCI.0889-12.2012.

PMID:
22623685
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Ginsenoside Rd attenuates beta-amyloid-induced tau phosphorylation by altering the functional balance of glycogen synthase kinase 3beta and protein phosphatase 2A.

Li L, Liu Z, Liu J, Tai X, Hu X, Liu X, Wu Z, Zhang G, Shi M, Zhao G.

Neurobiol Dis. 2013 Jun;54:320-8. doi: 10.1016/j.nbd.2013.01.002. Epub 2013 Jan 13.

PMID:
23321003
[PubMed - indexed for MEDLINE]
8.

Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576.

Chauhan NB, Siegel GJ, Feinstein DL.

Neuropharmacology. 2005 Jan;48(1):93-104.

PMID:
15617731
[PubMed - indexed for MEDLINE]
10.

GSK-3 inhibitors for Alzheimer's disease.

Avila J, Hernández F.

Expert Rev Neurother. 2007 Nov;7(11):1527-33. Review.

PMID:
17997701
[PubMed - indexed for MEDLINE]
11.

Amyloid-beta neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3beta, tau and neuroinflammation.

Hoppe JB, Frozza RL, Horn AP, Comiran RA, Bernardi A, Campos MM, Battastini AM, Salbego C.

J Pineal Res. 2010 Apr;48(3):230-8. doi: 10.1111/j.1600-079X.2010.00747.x. Epub 2010 Jan 28.

PMID:
20136701
[PubMed - indexed for MEDLINE]
12.

Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models.

Qing H, He G, Ly PT, Fox CJ, Staufenbiel M, Cai F, Zhang Z, Wei S, Sun X, Chen CH, Zhou W, Wang K, Song W.

J Exp Med. 2008 Nov 24;205(12):2781-9. doi: 10.1084/jem.20081588. Epub 2008 Oct 27.

PMID:
18955571
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

GSK-3 is essential in the pathogenesis of Alzheimer's disease.

Takashima A.

J Alzheimers Dis. 2006;9(3 Suppl):309-17. Review.

PMID:
16914869
[PubMed - indexed for MEDLINE]
14.

Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3.

Engel T, Hernández F, Avila J, Lucas JJ.

J Neurosci. 2006 May 10;26(19):5083-90.

PMID:
16687499
[PubMed - indexed for MEDLINE]
Free Article
15.

Newly developed glycogen synthase kinase-3 (GSK-3) inhibitors protect neuronal cells death in amyloid-beta induced cell model and in a transgenic mouse model of Alzheimer's disease.

Noh MY, Chun K, Kang BY, Kim H, Park JS, Lee HC, Kim YH, Ku S, Kim SH.

Biochem Biophys Res Commun. 2013 May 31;435(2):274-81. doi: 10.1016/j.bbrc.2013.04.065. Epub 2013 Apr 28.

PMID:
23632329
[PubMed - indexed for MEDLINE]
16.

Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: role of GSK-3beta in adult brain.

Takashima A.

J Pharmacol Sci. 2009 Feb;109(2):174-8. Epub 2009 Jan 29. Review.

PMID:
19179803
[PubMed - indexed for MEDLINE]
Free Article
17.

Maintained activity of glycogen synthase kinase-3beta despite of its phosphorylation at serine-9 in okadaic acid-induced neurodegenerative model.

Lim YW, Yoon SY, Choi JE, Kim SM, Lee HS, Choe H, Lee SC, Kim DH.

Biochem Biophys Res Commun. 2010 Apr 30;395(2):207-12. doi: 10.1016/j.bbrc.2010.03.163. Epub 2010 Apr 1.

PMID:
20362550
[PubMed - indexed for MEDLINE]
18.

Amyloid-beta-induced neurotoxicity is reduced by inhibition of glycogen synthase kinase-3.

Koh SH, Noh MY, Kim SH.

Brain Res. 2008 Jan 10;1188:254-62. Epub 2007 Nov 1.

PMID:
18031715
[PubMed - indexed for MEDLINE]
19.

Long-term treatment with lithium alleviates memory deficits and reduces amyloid-β production in an aged Alzheimer's disease transgenic mouse model.

Zhang X, Heng X, Li T, Li L, Yang D, Zhang X, Du Y, Doody RS, Le W.

J Alzheimers Dis. 2011;24(4):739-49. doi: 10.3233/JAD-2011-101875.

PMID:
21321394
[PubMed - indexed for MEDLINE]
20.

The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease.

Lanzillotta A, Sarnico I, Benarese M, Branca C, Baiguera C, Hutter-Paier B, Windisch M, Spano P, Imbimbo BP, Pizzi M.

J Mol Neurosci. 2011 Sep;45(1):22-31. doi: 10.1007/s12031-010-9482-2. Epub 2010 Dec 22.

PMID:
21181298
[PubMed - indexed for MEDLINE]

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