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Results: 1 to 20 of 105

1.

Monitoring binding of HIV-1 capsid assembly inhibitors using (19)F ligand-and (15)N protein-based NMR and X-ray crystallography: early hit validation of a benzodiazepine series.

Goudreau N, Coulombe R, Faucher AM, Grand-Maître C, Lacoste JE, Lemke CT, Malenfant E, Bousquet Y, Fader L, Simoneau B, Mercier JF, Titolo S, Mason SW.

ChemMedChem. 2013 Mar;8(3):405-14. doi: 10.1002/cmdc.201200580. Epub 2013 Feb 10.

PMID:
23401268
[PubMed - indexed for MEDLINE]
2.

Novel inhibitor binding site discovery on HIV-1 capsid N-terminal domain by NMR and X-ray crystallography.

Goudreau N, Lemke CT, Faucher AM, Grand-Maître C, Goulet S, Lacoste JE, Rancourt J, Malenfant E, Mercier JF, Titolo S, Mason SW.

ACS Chem Biol. 2013 May 17;8(5):1074-82. doi: 10.1021/cb400075f. Epub 2013 Mar 25.

PMID:
23496828
[PubMed - indexed for MEDLINE]
3.

Distinct effects of two HIV-1 capsid assembly inhibitor families that bind the same site within the N-terminal domain of the viral CA protein.

Lemke CT, Titolo S, von Schwedler U, Goudreau N, Mercier JF, Wardrop E, Faucher AM, Coulombe R, Banik SS, Fader L, Gagnon A, Kawai SH, Rancourt J, Tremblay M, Yoakim C, Simoneau B, Archambault J, Sundquist WI, Mason SW.

J Virol. 2012 Jun;86(12):6643-55. doi: 10.1128/JVI.00493-12. Epub 2012 Apr 11.

PMID:
22496222
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Structure of the HIV-1 full-length capsid protein in a conformationally trapped unassembled state induced by small-molecule binding.

Du S, Betts L, Yang R, Shi H, Concel J, Ahn J, Aiken C, Zhang P, Yeh JI.

J Mol Biol. 2011 Feb 25;406(3):371-86. doi: 10.1016/j.jmb.2010.11.027. Epub 2010 Dec 10.

PMID:
21146540
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Rationally designed interfacial peptides are efficient in vitro inhibitors of HIV-1 capsid assembly with antiviral activity.

Bocanegra R, Nevot M, Doménech R, López I, Abián O, Rodríguez-Huete A, Cavasotto CN, Velázquez-Campoy A, Gómez J, Martínez MÁ, Neira JL, Mateu MG.

PLoS One. 2011;6(9):e23877. doi: 10.1371/journal.pone.0023877. Epub 2011 Sep 8.

PMID:
21931621
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallization via compound-mediated dimerization.

Lemke CT, Titolo S, Goudreau N, Faucher AM, Mason SW, Bonneau P.

Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1115-23. doi: 10.1107/S0907444913006409. Epub 2013 May 15.

PMID:
23695256
[PubMed - indexed for MEDLINE]
7.

Residues in the HIV-1 capsid assembly inhibitor binding site are essential for maintaining the assembly-competent quaternary structure of the capsid protein.

Bartonova V, Igonet S, Sticht J, Glass B, Habermann A, Vaney MC, Sehr P, Lewis J, Rey FA, Kraüsslich HG.

J Biol Chem. 2008 Nov 14;283(46):32024-33. doi: 10.1074/jbc.M804230200. Epub 2008 Sep 4.

PMID:
18772135
[PubMed - indexed for MEDLINE]
Free Article
8.

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: addressing configurational instability through scaffold modification.

Fader LD, Landry S, Morin S, Kawai SH, Bousquet Y, Hucke O, Goudreau N, Lemke CT, Bonneau P, Titolo S, Mason S, Simoneau B.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3396-400. doi: 10.1016/j.bmcl.2013.03.073. Epub 2013 Mar 28.

PMID:
23583513
[PubMed - indexed for MEDLINE]
9.

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: structure-activity relationships (SAR) of the C3-phenyl moiety.

Fader LD, Landry S, Goulet S, Morin S, Kawai SH, Bousquet Y, Dion I, Hucke O, Goudreau N, Lemke CT, Rancourt J, Bonneau P, Titolo S, Amad M, Garneau M, Duan J, Mason S, Simoneau B.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3401-5. doi: 10.1016/j.bmcl.2013.03.074. Epub 2013 Apr 3.

PMID:
23601710
[PubMed - indexed for MEDLINE]
10.

Site-specific structural variations accompanying tubular assembly of the HIV-1 capsid protein.

Bayro MJ, Chen B, Yau WM, Tycko R.

J Mol Biol. 2014 Mar 6;426(5):1109-27. doi: 10.1016/j.jmb.2013.12.021. Epub 2013 Dec 24.

PMID:
24370930
[PubMed - indexed for MEDLINE]
11.

Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes.

Lamorte L, Titolo S, Lemke CT, Goudreau N, Mercier JF, Wardrop E, Shah VB, von Schwedler UK, Langelier C, Banik SS, Aiken C, Sundquist WI, Mason SW.

Antimicrob Agents Chemother. 2013 Oct;57(10):4622-31. doi: 10.1128/AAC.00985-13. Epub 2013 Jul 1.

PMID:
23817385
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The dimerization domain of the HIV-1 capsid protein binds a capsid protein-derived peptide: a biophysical characterization.

Garzón MT, Lidón-Moya MC, Barrera FN, Prieto A, Gómez J, Mateu MG, Neira JL.

Protein Sci. 2004 Jun;13(6):1512-23.

PMID:
15152086
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

The capsid protein of human immunodeficiency virus: designing inhibitors of capsid assembly.

Neira JL.

FEBS J. 2009 Nov;276(21):6110-7. doi: 10.1111/j.1742-4658.2009.07314.x. Review.

PMID:
19825045
[PubMed - indexed for MEDLINE]
14.

Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein.

Kelly BN, Kyere S, Kinde I, Tang C, Howard BR, Robinson H, Sundquist WI, Summers MF, Hill CP.

J Mol Biol. 2007 Oct 19;373(2):355-66. Epub 2007 Aug 15.

PMID:
17826792
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Motions on the millisecond time scale and multiple conformations of HIV-1 capsid protein: implications for structural polymorphism of CA assemblies.

Byeon IJ, Hou G, Han Y, Suiter CL, Ahn J, Jung J, Byeon CH, Gronenborn AM, Polenova T.

J Am Chem Soc. 2012 Apr 11;134(14):6455-66. doi: 10.1021/ja300937v. Epub 2012 Apr 2.

PMID:
22428579
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Design, synthesis, structural characterization by IR, (1) H, (13) C, (15) N, 2D-NMR, X-ray diffraction and evaluation of a new class of phenylaminoacetic acid benzylidene hydrazines as pfENR inhibitors.

Samal RP, Khedkar VM, Pissurlenkar RR, Bwalya AG, Tasdemir D, Joshi RA, Rajamohanan PR, Puranik VG, Coutinho EC.

Chem Biol Drug Des. 2013 Jun;81(6):715-29. doi: 10.1111/cbdd.12118. Epub 2013 Apr 11.

PMID:
23398677
[PubMed - indexed for MEDLINE]
17.

The isolated major homology region of the HIV capsid protein is mainly unfolded in solution and binds to the intact protein.

Doménech R, Bocanegra R, Velázquez-Campoy A, Neira JL.

Biochim Biophys Acta. 2011 Oct;1814(10):1269-78. doi: 10.1016/j.bbapap.2011.06.011. Epub 2011 Jul 6.

PMID:
21745604
[PubMed - indexed for MEDLINE]
Free Article
18.

Assembly properties of the human immunodeficiency virus type 1 CA protein.

Ganser-Pornillos BK, von Schwedler UK, Stray KM, Aiken C, Sundquist WI.

J Virol. 2004 Mar;78(5):2545-52.

PMID:
14963157
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

1H, 15N, and 13C resonance assignments for a monomeric mutant of the HIV-1 capsid protein.

Shin R, Tzou YM, Wong HC, Krishna NR.

Biomol NMR Assign. 2012 Oct;6(2):131-4. doi: 10.1007/s12104-011-9340-3. Epub 2011 Sep 20.

PMID:
21932031
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

HIV capsid is a tractable target for small molecule therapeutic intervention.

Blair WS, Pickford C, Irving SL, Brown DG, Anderson M, Bazin R, Cao J, Ciaramella G, Isaacson J, Jackson L, Hunt R, Kjerrstrom A, Nieman JA, Patick AK, Perros M, Scott AD, Whitby K, Wu H, Butler SL.

PLoS Pathog. 2010 Dec 9;6(12):e1001220. doi: 10.1371/journal.ppat.1001220.

PMID:
21170360
[PubMed - indexed for MEDLINE]
Free PMC Article

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