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Results: 1 to 20 of 102

1.

Non-allosteric enzyme switches possess larger effector-induced changes in thermodynamic stability than their non-switch analogs.

Choi JH, San A, Ostermeier M.

Protein Sci. 2013 Apr;22(4):475-85. doi: 10.1002/pro.2234. Epub 2013 Mar 8.

PMID:
23400970
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

In vitro recombination of non-homologous genes can result in gene fusions that confer a switching phenotype to cells.

Heins RA, Choi JH, Sohka T, Ostermeier M.

PLoS One. 2011;6(11):e27302. doi: 10.1371/journal.pone.0027302. Epub 2011 Nov 11.

PMID:
22096548
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

NMR characterization of an engineered domain fusion between maltose binding protein and TEM1 beta-lactamase provides insight into its structure and allosteric mechanism.

Wright CM, Majumdar A, Tolman JR, Ostermeier M.

Proteins. 2010 May 1;78(6):1423-30. doi: 10.1002/prot.22657.

PMID:
20034108
[PubMed - indexed for MEDLINE]
4.

Directed evolution of protein switches and their application to the creation of ligand-binding proteins.

Guntas G, Mansell TJ, Kim JR, Ostermeier M.

Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11224-9. Epub 2005 Aug 1.

PMID:
16061816
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Modulation of effector affinity by hinge region mutations also modulates switching activity in an engineered allosteric TEM1 beta-lactamase switch.

Kim JR, Ostermeier M.

Arch Biochem Biophys. 2006 Feb 1;446(1):44-51. Epub 2005 Dec 9.

PMID:
16384549
[PubMed - indexed for MEDLINE]
6.

Surface-tethered protein switches.

Zayats M, Kanwar M, Ostermeier M, Searson PC.

Chem Commun (Camb). 2011 Mar 28;47(12):3398-400. doi: 10.1039/c1cc10146c. Epub 2011 Feb 18.

PMID:
21331440
[PubMed - indexed for MEDLINE]
7.

Structure of an engineered β-lactamase maltose binding protein fusion protein: insights into heterotropic allosteric regulation.

Ke W, Laurent AH, Armstrong MD, Chen Y, Smith WE, Liang J, Wright CM, Ostermeier M, van den Akker F.

PLoS One. 2012;7(6):e39168. doi: 10.1371/journal.pone.0039168. Epub 2012 Jun 14.

PMID:
22720063
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Ligand binding and allostery can emerge simultaneously.

Liang J, Kim JR, Boock JT, Mansell TJ, Ostermeier M.

Protein Sci. 2007 May;16(5):929-37. Epub 2007 Mar 30.

PMID:
17400921
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

A molecular switch created by in vitro recombination of nonhomologous genes.

Guntas G, Mitchell SF, Ostermeier M.

Chem Biol. 2004 Nov;11(11):1483-7.

PMID:
15555998
[PubMed - indexed for MEDLINE]
Free Article
10.

Engineering switches, genetically.

Roberts RW.

Chem Biol. 2004 Nov;11(11):1475-6.

PMID:
15555994
[PubMed - indexed for MEDLINE]
Free Article
11.

Engineering an allosteric binding site for aminoglycosides into TEM1-β-Lactamase.

Volkov AN, Barrios H, Mathonet P, Evrard C, Ubbink M, Declercq JP, Soumillion P, Fastrez J.

Chembiochem. 2011 Apr 11;12(6):904-13. doi: 10.1002/cbic.201000568. Epub 2011 Mar 18.

PMID:
21425229
[PubMed - indexed for MEDLINE]
12.

Creation of an allosteric enzyme by domain insertion.

Guntas G, Ostermeier M.

J Mol Biol. 2004 Feb 6;336(1):263-73.

PMID:
14741221
[PubMed - indexed for MEDLINE]
13.

Engineering allosteric protein switches by domain insertion.

Ostermeier M.

Protein Eng Des Sel. 2005 Aug;18(8):359-64. Epub 2005 Jul 25. Review.

PMID:
16043448
[PubMed - indexed for MEDLINE]
Free Article
14.

IcsA autotransporter passenger promotes increased fusion protein expression on the cell surface.

Lum M, Morona R.

Microb Cell Fact. 2012 Feb 7;11:20. doi: 10.1186/1475-2859-11-20.

PMID:
22309506
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Class A β-lactamases as versatile scaffolds to create hybrid enzymes: applications from basic research to medicine.

Huynen C, Filée P, Matagne A, Galleni M, Dumoulin M.

Biomed Res Int. 2013;2013:827621. doi: 10.1155/2013/827621. Epub 2013 Aug 28. Review.

PMID:
24066299
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The ability to enhance the solubility of its fusion partners is an intrinsic property of maltose-binding protein but their folding is either spontaneous or chaperone-mediated.

Raran-Kurussi S, Waugh DS.

PLoS One. 2012;7(11):e49589. doi: 10.1371/journal.pone.0049589. Epub 2012 Nov 16.

PMID:
23166722
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Design of generic biosensors based on green fluorescent proteins with allosteric sites by directed evolution.

Doi N, Yanagawa H.

FEBS Lett. 1999 Jun 25;453(3):305-7.

PMID:
10405165
[PubMed - indexed for MEDLINE]
Free Article
18.

Construction of multiple recombinant SLA-I proteins by linking heavy chains and light chains in vitro and analyzing their secondary and 3-dimensional structures.

Gao FS, Bai J, Zhang Q, Xu CB, Li Y.

Gene. 2012 Jul 10;502(2):147-53. doi: 10.1016/j.gene.2012.04.038. Epub 2012 Apr 24.

PMID:
22555023
[PubMed - indexed for MEDLINE]
19.

Designing redox potential-controlled protein switches based on mutually exclusive proteins.

Peng Q, Kong N, Wang HC, Li H.

Protein Sci. 2012 Aug;21(8):1222-30. doi: 10.1002/pro.2109.

PMID:
22733630
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Linking the functions of unrelated proteins using a novel directed evolution domain insertion method.

Edwards WR, Busse K, Allemann RK, Jones DD.

Nucleic Acids Res. 2008 Aug;36(13):e78. doi: 10.1093/nar/gkn363. Epub 2008 Jun 17.

PMID:
18559359
[PubMed - indexed for MEDLINE]
Free PMC Article

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