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Items: 1 to 20 of 109

1.

Natural Bcl-2 inhibitor (-)- gossypol induces protective autophagy via reactive oxygen species-high mobility group box 1 pathway in Burkitt lymphoma.

Ni Z, Dai X, Wang B, Ding W, Cheng P, Xu L, Lian J, He F.

Leuk Lymphoma. 2013 Oct;54(10):2263-8. doi: 10.3109/10428194.2013.775437. Epub 2013 Mar 13.

PMID:
23398207
2.

The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells.

Cheng P, Ni Z, Dai X, Wang B, Ding W, Rae Smith A, Xu L, Wu D, He F, Lian J.

Cell Death Dis. 2013 Feb 7;4:e489. doi: 10.1038/cddis.2013.17. Erratum in: Cell Death Dis. 2013;4:e598.

3.

The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma.

Voss V, Senft C, Lang V, Ronellenfitsch MW, Steinbach JP, Seifert V, Kögel D.

Mol Cancer Res. 2010 Jul;8(7):1002-16. doi: 10.1158/1541-7786.MCR-09-0562. Epub 2010 Jun 29.

4.

The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells.

Lian J, Karnak D, Xu L.

Autophagy. 2010 Nov;6(8):1201-3. doi: 10.1038/cdd.2010.74. Epub 2010 Nov 16.

5.

Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells.

Ko CH, Shen SC, Yang LY, Lin CW, Chen YC.

Int J Cancer. 2007 Oct 15;121(8):1670-9.

6.

The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells.

Gao P, Bauvy C, Souquère S, Tonelli G, Liu L, Zhu Y, Qiao Z, Bakula D, Proikas-Cezanne T, Pierron G, Codogno P, Chen Q, Mehrpour M.

J Biol Chem. 2010 Aug 13;285(33):25570-81. doi: 10.1074/jbc.M110.118125. Epub 2010 Jun 7.

7.

Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-κB survival pathway in A375-S2 cells.

He H, Zang LH, Feng YS, Chen LX, Kang N, Tashiro S, Onodera S, Qiu F, Ikejima T.

J Ethnopharmacol. 2013 Jul 9;148(2):544-55. doi: 10.1016/j.jep.2013.04.051. Epub 2013 May 14.

PMID:
23684722
8.

Apogossypolone induces reactive oxygen species accumulation and controls cell cycle progression in Raji Burkkit's lymphoma cells.

Hu ZY, Xu F, Sun R, Chen YF, Zhang DS, Fan YH, Sun J.

Mol Med Rep. 2015 Jul;12(1):337-44. doi: 10.3892/mmr.2015.3404. Epub 2015 Mar 3.

PMID:
25738577
9.

Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101).

Mani J, Vallo S, Rakel S, Antonietti P, Gessler F, Blaheta R, Bartsch G, Michaelis M, Cinatl J, Haferkamp A, Kögel D.

BMC Cancer. 2015 Apr 7;15:224. doi: 10.1186/s12885-015-1239-4.

10.

Hsp90 inhibitor 17-AAG sensitizes Bcl-2 inhibitor (-)-gossypol by suppressing ERK-mediated protective autophagy and Mcl-1 accumulation in hepatocellular carcinoma cells.

Wang B, Chen L, Ni Z, Dai X, Qin L, Wu Y, Li X, Xu L, Lian J, He F.

Exp Cell Res. 2014 Nov 1;328(2):379-87. doi: 10.1016/j.yexcr.2014.08.039. Epub 2014 Sep 6.

PMID:
25196280
11.

Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.

Lian J, Ni Z, Dai X, Su C, Smith AR, Xu L, He F.

Mol Cancer Ther. 2012 Feb;11(2):416-26. doi: 10.1158/1535-7163.MCT-11-0559. Epub 2011 Dec 21.

12.

Anti-oxidant treatment enhances anti-tumor cytotoxicity of (-)-gossypol.

Sikora MJ, Bauer JA, Verhaegen M, Belbin TJ, Prystowsky MB, Taylor JC, Brenner JC, Wang S, Soengas MS, Bradford CR, Carey TE.

Cancer Biol Ther. 2008 May;7(5):767-76. Epub 2008 May 20.

13.

Autophagy inhibition enhances pan-Bcl-2 inhibitor AT-101-induced apoptosis in non-small cell lung cancer.

Mei H, Lin Z, Wang Y, Wu G, Song Y.

Neoplasma. 2014;61(2):186-92. doi: 10.4149/neo_2014_024.

PMID:
24299314
14.

Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma.

Mohammad RM, Wang S, Aboukameel A, Chen B, Wu X, Chen J, Al-Katib A.

Mol Cancer Ther. 2005 Jan;4(1):13-21.

15.

A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells.

Kim AD, Kang KA, Kim HS, Kim DH, Choi YH, Lee SJ, Kim HS, Hyun JW.

Cell Death Dis. 2013 Aug 1;4:e750. doi: 10.1038/cddis.2013.273.

16.

Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.

Sung B, Ravindran J, Prasad S, Pandey MK, Aggarwal BB.

J Biol Chem. 2010 Nov 12;285(46):35418-27. doi: 10.1074/jbc.M110.172767. Epub 2010 Sep 13.

17.
18.

Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro.

Zhang XQ, Huang XF, Hu XB, Zhan YH, An QX, Yang SM, Xia AJ, Yi J, Chen R, Mu SJ, Wu DC.

Asian J Androl. 2010 Sep;12(5):697-708. doi: 10.1038/aja.2010.57. Epub 2010 Jul 26.

19.

Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells.

Balakrishnan K, Wierda WG, Keating MJ, Gandhi V.

Blood. 2008 Sep 1;112(5):1971-80. doi: 10.1182/blood-2007-12-126946. Epub 2008 Jun 19.

20.

Neuregulin promotes incomplete autophagy of prostate cancer cells that is independent of mTOR pathway inhibition.

Schmukler E, Shai B, Ehrlich M, Pinkas-Kramarski R.

PLoS One. 2012;7(5):e36828. doi: 10.1371/journal.pone.0036828. Epub 2012 May 14.

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