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Results: 1 to 20 of 105

1.

Molecular dissection of botulinum neurotoxin reveals interdomain chaperone function.

Fischer A, Montal M.

Toxicon. 2013 Dec 1;75:101-7. doi: 10.1016/j.toxicon.2013.01.007. Epub 2013 Feb 5. Review.

PMID:
23396042
[PubMed - indexed for MEDLINE]
2.

Single molecule detection of intermediates during botulinum neurotoxin translocation across membranes.

Fischer A, Montal M.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10447-52. Epub 2007 Jun 11.

PMID:
17563359
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Synchronized chaperone function of botulinum neurotoxin domains mediates light chain translocation into neurons.

Fischer A.

Curr Top Microbiol Immunol. 2013;364:115-37. doi: 10.1007/978-3-642-33570-9_6.

PMID:
23239351
[PubMed - indexed for MEDLINE]
4.

Crucial role of the disulfide bridge between botulinum neurotoxin light and heavy chains in protease translocation across membranes.

Fischer A, Montal M.

J Biol Chem. 2007 Oct 5;282(40):29604-11. Epub 2007 Jul 31.

PMID:
17666397
[PubMed - indexed for MEDLINE]
Free Article
5.

Botulinum neurotoxin devoid of receptor binding domain translocates active protease.

Fischer A, Mushrush DJ, Lacy DB, Montal M.

PLoS Pathog. 2008 Dec;4(12):e1000245. doi: 10.1371/journal.ppat.1000245. Epub 2008 Dec 19.

PMID:
19096517
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Translocation of botulinum neurotoxin light chain protease by the heavy chain protein-conducting channel.

Montal M.

Toxicon. 2009 Oct;54(5):565-9. doi: 10.1016/j.toxicon.2008.11.018. Epub 2008 Dec 14. Review.

PMID:
19111565
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Beltless translocation domain of botulinum neurotoxin A embodies a minimum ion-conductive channel.

Fischer A, Sambashivan S, Brunger AT, Montal M.

J Biol Chem. 2012 Jan 13;287(3):1657-61. doi: 10.1074/jbc.C111.319400. Epub 2011 Dec 12.

PMID:
22158863
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Translocation of botulinum neurotoxin light chain protease through the heavy chain channel.

Koriazova LK, Montal M.

Nat Struct Biol. 2003 Jan;10(1):13-8.

PMID:
12459720
[PubMed - indexed for MEDLINE]
10.

Light chain separated from the rest of the type a botulinum neurotoxin molecule is the most catalytically active form.

Gul N, Smith LA, Ahmed SA.

PLoS One. 2010 Sep 22;5(9):e12872. doi: 10.1371/journal.pone.0012872.

PMID:
20877571
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons.

Höltje M, Schulze S, Strotmeier J, Mahrhold S, Richter K, Binz T, Bigalke H, Ahnert-Hilger G, Rummel A.

Toxicon. 2013 Dec 1;75:108-21. doi: 10.1016/j.toxicon.2013.06.010. Epub 2013 Jun 29.

PMID:
23817019
[PubMed - indexed for MEDLINE]
12.

Botulinum neurotoxin light chain refolds at endosomal pH for its translocation.

Cai S, Kukreja R, Shoesmith S, Chang TW, Singh BR.

Protein J. 2006 Dec;25(7-8):455-62.

PMID:
17115255
[PubMed - indexed for MEDLINE]
13.

Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

Pirazzini M, Henke T, Rossetto O, Mahrhold S, Krez N, Rummel A, Montecucco C, Binz T.

FEBS Lett. 2013 Nov 29;587(23):3831-6. doi: 10.1016/j.febslet.2013.10.010. Epub 2013 Oct 21.

PMID:
24157364
[PubMed - indexed for MEDLINE]
14.

Preliminary X-ray crystallographic study of the receptor-binding domain of the D/C mosaic neurotoxin from Clostridium botulinum.

Nuemket N, Tanaka Y, Tsukamoto K, Tsuji T, Nakamura K, Kozaki S, Yao M, Tanaka I.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 May 1;66(Pt 5):608-10. doi: 10.1107/S1744309110012182. Epub 2010 Apr 30.

PMID:
20445271
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly.

Sun S, Suresh S, Liu H, Tepp WH, Johnson EA, Edwardson JM, Chapman ER.

Cell Host Microbe. 2011 Sep 15;10(3):237-47. doi: 10.1016/j.chom.2011.06.012.

PMID:
21925111
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation.

Kumaran D, Eswaramoorthy S, Furey W, Navaza J, Sax M, Swaminathan S.

J Mol Biol. 2009 Feb 13;386(1):233-45. doi: 10.1016/j.jmb.2008.12.027. Epub 2008 Dec 24.

PMID:
19118561
[PubMed - indexed for MEDLINE]
17.

Effect of nicking the C-terminal region of the Clostridium botulinum serotype D neurotoxin heavy chain on its toxicity and molecular properties.

Suzuki T, Kouguchi H, Watanabe T, Hasegawa K, Yoneyama T, Niwa K, Nishikawa A, Lee JC, Oguma K, Ohyama T.

Protein J. 2007 Apr;26(3):173-81.

PMID:
17200883
[PubMed - indexed for MEDLINE]
18.

Bimodal modulation of the botulinum neurotoxin protein-conducting channel.

Fischer A, Nakai Y, Eubanks LM, Clancy CM, Tepp WH, Pellett S, Dickerson TJ, Johnson EA, Janda KD, Montal M.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1330-5. doi: 10.1073/pnas.0812839106. Epub 2009 Jan 21.

PMID:
19164566
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Transforming the domain structure of botulinum neurotoxins into novel therapeutics.

Chaddock J.

Curr Top Microbiol Immunol. 2013;364:287-306. doi: 10.1007/978-3-642-33570-9_13. Review.

PMID:
23239358
[PubMed - indexed for MEDLINE]
20.

Immunological characterization of the neurotoxin produced by Clostridium botulinum type A associated with infant botulism in Japan.

Kozaki S, Nakaue S, Kamata Y.

Microbiol Immunol. 1995;39(10):767-74.

PMID:
8577267
[PubMed - indexed for MEDLINE]

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