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Results: 1 to 20 of 94

1.

Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.

Ghosh MC, Zhang DL, Jeong SY, Kovtunovych G, Ollivierre-Wilson H, Noguchi A, Tu T, Senecal T, Robinson G, Crooks DR, Tong WH, Ramaswamy K, Singh A, Graham BB, Tuder RM, Yu ZX, Eckhaus M, Lee J, Springer DA, Rouault TA.

Cell Metab. 2013 Feb 5;17(2):271-81. doi: 10.1016/j.cmet.2012.12.016.

PMID:
23395173
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.

Anderson SA, Nizzi CP, Chang YI, Deck KM, Schmidt PJ, Galy B, Damnernsawad A, Broman AT, Kendziorski C, Hentze MW, Fleming MD, Zhang J, Eisenstein RS.

Cell Metab. 2013 Feb 5;17(2):282-90. doi: 10.1016/j.cmet.2013.01.007.

PMID:
23395174
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation.

Wilkinson N, Pantopoulos K.

Blood. 2013 Aug 29;122(9):1658-68. doi: 10.1182/blood-2013-03-492454. Epub 2013 Jun 18.

PMID:
23777768
[PubMed - indexed for MEDLINE]
Free Article
4.

The IRP/IRE system in vivo: insights from mouse models.

Wilkinson N, Pantopoulos K.

Front Pharmacol. 2014 Jul 28;5:176. doi: 10.3389/fphar.2014.00176. eCollection 2014. Review.

PMID:
25120486
[PubMed]
Free PMC Article
5.

Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide.

Styś A, Galy B, Starzyński RR, Smuda E, Drapier JC, Lipiński P, Bouton C.

J Biol Chem. 2011 Jul 1;286(26):22846-54. doi: 10.1074/jbc.M111.231902. Epub 2011 May 12.

PMID:
21566147
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation.

Tan Q, Kerestes H, Percy MJ, Pietrofesa R, Chen L, Khurana TS, Christofidou-Solomidou M, Lappin TR, Lee FS.

J Biol Chem. 2013 Jun 14;288(24):17134-44. doi: 10.1074/jbc.M112.444059. Epub 2013 May 2.

PMID:
23640890
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice.

Ghosh MC, Tong WH, Zhang D, Ollivierre-Wilson H, Singh A, Krishna MC, Mitchell JB, Rouault TA.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12028-33. doi: 10.1073/pnas.0805361105. Epub 2008 Aug 6.

PMID:
18685102
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The physiological functions of iron regulatory proteins in iron homeostasis - an update.

Zhang DL, Ghosh MC, Rouault TA.

Front Pharmacol. 2014 Jun 13;5:124. doi: 10.3389/fphar.2014.00124. eCollection 2014. Review.

PMID:
24982634
[PubMed]
Free PMC Article
9.

Excess capacity of the iron regulatory protein system.

Wang W, Di X, D'Agostino RB Jr, Torti SV, Torti FM.

J Biol Chem. 2007 Aug 24;282(34):24650-9. Epub 2007 Jun 28.

PMID:
17604281
[PubMed - indexed for MEDLINE]
Free Article
10.

Targeting HIF2α translation with Tempol in VHL-deficient clear cell renal cell carcinoma.

Sourbier C, Srivastava G, Ghosh MC, Ghosh S, Yang Y, Gupta G, Degraff W, Krishna MC, Mitchell JB, Rouault TA, Linehan WM.

Oncotarget. 2012 Nov;3(11):1472-82.

PMID:
23178531
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins.

Christova T, Templeton DM.

Mol Cell Biochem. 2007 Jul;301(1-2):21-32. Epub 2007 Jan 3.

PMID:
17200797
[PubMed - indexed for MEDLINE]
12.

Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development.

Smith SR, Ghosh MC, Ollivierre-Wilson H, Hang Tong W, Rouault TA.

Blood Cells Mol Dis. 2006 Mar-Apr;36(2):283-7. Epub 2006 Feb 15.

PMID:
16480904
[PubMed - indexed for MEDLINE]
13.

Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice.

Kim BH, Jun YC, Jin JK, Kim JI, Kim NH, Leibold EA, Connor JR, Choi EK, Carp RI, Kim YS.

Neurosci Lett. 2007 Jul 18;422(3):158-63. Epub 2007 Jun 14.

PMID:
17614197
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia.

Brusselmans K, Compernolle V, Tjwa M, Wiesener MS, Maxwell PH, Collen D, Carmeliet P.

J Clin Invest. 2003 May;111(10):1519-27.

PMID:
12750401
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo.

Meyron-Holtz EG, Ghosh MC, Rouault TA.

Science. 2004 Dec 17;306(5704):2087-90.

PMID:
15604406
[PubMed - indexed for MEDLINE]
Free Article
16.

Multiple, conserved iron-responsive elements in the 3'-untranslated region of transferrin receptor mRNA enhance binding of iron regulatory protein 2.

Erlitzki R, Long JC, Theil EC.

J Biol Chem. 2002 Nov 8;277(45):42579-87. Epub 2002 Aug 27.

PMID:
12200453
[PubMed - indexed for MEDLINE]
Free Article
17.

Hypoxia inducible factor-2 α is translationally repressed in response to dietary iron deficiency in Sprague-Dawley rats.

Davis MR, Shawron KM, Rendina E, Peterson SK, Lucas EA, Smith BJ, Clarke SL.

J Nutr. 2011 Sep;141(9):1590-6. doi: 10.3945/jn.111.144105. Epub 2011 Jul 13.

PMID:
21753061
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line.

Schalinske KL, Blemings KP, Steffen DW, Chen OS, Eisenstein RS.

Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10681-6.

PMID:
9380695
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function.

Casarrubea D, Viatte L, Hallas T, Vasanthakumar A, Eisenstein RS, Schümann K, Hentze MW, Galy B.

J Mol Med (Berl). 2013 Jul;91(7):871-81. doi: 10.1007/s00109-013-1008-2. Epub 2013 Mar 1.

PMID:
23455710
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency.

Sanchez M, Galy B, Muckenthaler MU, Hentze MW.

Nat Struct Mol Biol. 2007 May;14(5):420-6. Epub 2007 Apr 8.

PMID:
17417656
[PubMed - indexed for MEDLINE]
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