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Results: 1 to 20 of 110

1.

Mutational biosynthesis of tacrolimus analogues by fkbO deletion mutant of Streptomyces sp. KCTC 11604BP.

Kim DH, Ryu JH, Lee KS, Lee BM, Lee MO, Lim SK, Maeng PJ.

Appl Microbiol Biotechnol. 2013 Jul;97(13):5881-92. doi: 10.1007/s00253-013-4716-1. Epub 2013 Feb 8.

PMID:
23392766
[PubMed - indexed for MEDLINE]
2.

Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit.

Ban YH, Lee JH, Gu GR, Lee B, Mo S, Kwon HJ, Yoon YJ.

Mol Biosyst. 2013 May;9(5):944-7. doi: 10.1039/c2mb25419k.

PMID:
23223556
[PubMed - indexed for MEDLINE]
3.

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.

Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4776-81. doi: 10.1073/pnas.1015773108. Epub 2011 Mar 7.

PMID:
21383123
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.

Wu K, Chung L, Revill WP, Katz L, Reeves CD.

Gene. 2000 Jun 13;251(1):81-90.

PMID:
10863099
[PubMed - indexed for MEDLINE]
5.

Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BP.

Mo S, Yoo YJ, Ban YH, Lee SK, Kim E, Suh JW, Yoon YJ.

Appl Environ Microbiol. 2012 Apr;78(7):2249-55. doi: 10.1128/AEM.06766-11. Epub 2012 Jan 20.

PMID:
22267670
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Application of a combined approach involving classical random mutagenesis and metabolic engineering to enhance FK506 production in Streptomyces sp. RM7011.

Mo S, Lee SK, Jin YY, Oh CH, Suh JW.

Appl Microbiol Biotechnol. 2013 Apr;97(7):3053-62. doi: 10.1007/s00253-012-4413-5. Epub 2012 Oct 2.

PMID:
23053074
[PubMed - indexed for MEDLINE]
7.

Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies.

Huang D, Xia M, Li S, Wen J, Jia X.

J Ind Microbiol Biotechnol. 2013 Sep;40(9):1023-37. doi: 10.1007/s10295-013-1301-7. Epub 2013 Jun 19.

PMID:
23779221
[PubMed - indexed for MEDLINE]
8.

The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506.

Motamedi H, Shafiee A.

Eur J Biochem. 1998 Sep 15;256(3):528-34.

PMID:
9780228
[PubMed - indexed for MEDLINE]
Free Article
9.

Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.

Mo S, Kim DH, Lee JH, Park JW, Basnet DB, Ban YH, Yoo YJ, Chen SW, Park SR, Choi EA, Kim E, Jin YY, Lee SK, Park JY, Liu Y, Lee MO, Lee KS, Kim SJ, Kim D, Park BC, Lee SG, Kwon HJ, Suh JW, Moore BS, Lim SK, Yoon YJ.

J Am Chem Soc. 2011 Feb 2;133(4):976-85. doi: 10.1021/ja108399b. Epub 2010 Dec 22.

PMID:
21175203
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis.

Goranovič D, Blažič M, Magdevska V, Horvat J, Kuščer E, Polak T, Santos-Aberturas J, Martínez-Castro M, Barreiro C, Mrak P, Kopitar G, Kosec G, Fujs S, Martín JF, Petković H.

BMC Microbiol. 2012 Oct 19;12:238. doi: 10.1186/1471-2180-12-238.

PMID:
23083511
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506).

Barreiro C, Prieto C, Sola-Landa A, Solera E, Martínez-Castro M, Pérez-Redondo R, García-Estrada C, Aparicio JF, Fernández-Martínez LT, Santos-Aberturas J, Salehi-Najafabadi Z, Rodríguez-García A, Tauch A, Martín JF.

J Bacteriol. 2012 Jul;194(14):3756-7. doi: 10.1128/JB.00692-12.

PMID:
22740677
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506).

Barreiro C, Martínez-Castro M.

Appl Microbiol Biotechnol. 2014 Jan;98(2):497-507. doi: 10.1007/s00253-013-5362-3. Epub 2013 Nov 24. Review.

PMID:
24272367
[PubMed - indexed for MEDLINE]
13.

Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus.

Kuscer E, Coates N, Challis I, Gregory M, Wilkinson B, Sheridan R, Petković H.

J Bacteriol. 2007 Jul;189(13):4756-63. Epub 2007 Apr 27.

PMID:
17468238
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Origin of the allyl group in FK506 biosynthesis.

Goranovic D, Kosec G, Mrak P, Fujs S, Horvat J, Kuscer E, Kopitar G, Petkovic H.

J Biol Chem. 2010 May 7;285(19):14292-300. doi: 10.1074/jbc.M109.059600. Epub 2010 Mar 1.

PMID:
20194504
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems.

Chen D, Zhang Q, Zhang Q, Cen P, Xu Z, Liu W.

Appl Environ Microbiol. 2012 Aug;78(15):5093-103. doi: 10.1128/AEM.00450-12. Epub 2012 May 11.

PMID:
22582065
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Mechanistic implications for the chorismatase FkbO based on the crystal structure.

Juneja P, Hubrich F, Diederichs K, Welte W, Andexer JN.

J Mol Biol. 2014 Jan 9;426(1):105-15. doi: 10.1016/j.jmb.2013.09.006. Epub 2013 Sep 13.

PMID:
24036425
[PubMed - indexed for MEDLINE]
17.

Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520.

Motamedi H, Shafiee A, Cai SJ, Streicher SL, Arison BH, Miller RR.

J Bacteriol. 1996 Sep;178(17):5243-8.

PMID:
8752344
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Recombinant strains for the enhanced production of bioengineered rapalogs.

Kendrew SG, Petkovic H, Gaisser S, Ready SJ, Gregory MA, Coates NJ, Nur-E-Alam M, Warneck T, Suthar D, Foster TA, McDonald L, Schlingman G, Koehn FE, Skotnicki JS, Carter GT, Moss SJ, Zhang MQ, Martin CJ, Sheridan RM, Wilkinson B.

Metab Eng. 2013 Jan;15:167-73. doi: 10.1016/j.ymben.2012.11.001. Epub 2012 Nov 17.

PMID:
23164580
[PubMed - indexed for MEDLINE]
19.

Efficient pyramidal arrangement of an ordered cosmid library: Rapid screening of genes of the tacrolimus-producer Streptomyces sp. ATCC 55098.

Martínez-Castro M, Solera E, Martín JF, Barreiro C.

J Microbiol Methods. 2009 Aug;78(2):150-4. doi: 10.1016/j.mimet.2009.05.005. Epub 2009 May 13.

PMID:
19445977
[PubMed - indexed for MEDLINE]
20.

Designed biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering.

Lechner A, Wilson MC, Ban YH, Hwang JY, Yoon YJ, Moore BS.

ACS Synth Biol. 2013 Jul 19;2(7):379-83. doi: 10.1021/sb3001062. Epub 2012 Nov 5.

PMID:
23654255
[PubMed - indexed for MEDLINE]
Free PMC Article

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