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Results: 1 to 20 of 114

1.

Effects of monocarboxylate transporter inhibition on the oral toxicokinetics/toxicodynamics of γ-hydroxybutyrate and γ-butyrolactone.

Morse BL, Morris ME.

J Pharmacol Exp Ther. 2013 Apr;345(1):102-10. doi: 10.1124/jpet.112.202796. Epub 2013 Feb 7.

PMID:
23392755
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Toxicokinetics/Toxicodynamics of γ-hydroxybutyrate-ethanol intoxication: evaluation of potential treatment strategies.

Morse BL, Morris ME.

J Pharmacol Exp Ther. 2013 Sep;346(3):504-13. doi: 10.1124/jpet.113.206250. Epub 2013 Jun 28.

PMID:
23814094
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Effects of L-lactate and D-mannitol on gamma-hydroxybutyrate toxicokinetics and toxicodynamics in rats.

Wang Q, Wang X, Morris ME.

Drug Metab Dispos. 2008 Nov;36(11):2244-51. doi: 10.1124/dmd.108.022996. Epub 2008 Aug 21.

PMID:
18719239
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

γ-Hydroxybutyrate (GHB)-induced respiratory depression: combined receptor-transporter inhibition therapy for treatment in GHB overdose.

Morse BL, Vijay N, Morris ME.

Mol Pharmacol. 2012 Aug;82(2):226-35. doi: 10.1124/mol.112.078154. Epub 2012 May 4.

PMID:
22561075
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Brain extracellular γ-hydroxybutyrate concentrations are decreased by L-lactate in rats: role in the treatment of overdoses.

Roiko SA, Vijay N, Felmlee MA, Morris ME.

Pharm Res. 2013 May;30(5):1338-48. doi: 10.1007/s11095-013-0973-z. Epub 2013 Jan 15.

PMID:
23319173
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Monocarboxylate Transporter Inhibition with Osmotic Diuresis Increases γ-Hydroxybutyrate Renal Elimination in Humans: A Proof-of-Concept Study.

Morris ME, Morse BL, Baciewicz GJ, Tessena MM, Acquisto NM, Hutchinson DJ, Dicenzo R.

J Clin Toxicol. 2011 Nov 10;1(2):1000105.

PMID:
24772380
[PubMed]
Free PMC Article
7.

Pharmacokinetic interaction between the flavonoid luteolin and gamma-hydroxybutyrate in rats: potential involvement of monocarboxylate transporters.

Wang X, Wang Q, Morris ME.

AAPS J. 2008;10(1):47-55. doi: 10.1208/s12248-007-9001-8. Epub 2008 Jan 30.

PMID:
18446505
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

γ-Hydroxybutyrate blood/plasma partitioning: effect of physiologic pH on transport by monocarboxylate transporters.

Morse BL, Felmlee MA, Morris ME.

Drug Metab Dispos. 2012 Jan;40(1):64-9. doi: 10.1124/dmd.111.041285. Epub 2011 Oct 5.

PMID:
21976619
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Transport of gamma-hydroxybutyrate in rat kidney membrane vesicles: Role of monocarboxylate transporters.

Wang Q, Darling IM, Morris ME.

J Pharmacol Exp Ther. 2006 Aug;318(2):751-61. Epub 2006 May 17.

PMID:
16707723
[PubMed - indexed for MEDLINE]
Free Article
10.

Renal clearance of gamma-hydroxybutyric acid in rats: increasing renal elimination as a detoxification strategy.

Morris ME, Hu K, Wang Q.

J Pharmacol Exp Ther. 2005 Jun;313(3):1194-202. Epub 2005 Feb 18.

PMID:
15722403
[PubMed - indexed for MEDLINE]
Free Article
11.

The drug of abuse gamma-hydroxybutyrate is a substrate for sodium-coupled monocarboxylate transporter (SMCT) 1 (SLC5A8): characterization of SMCT-mediated uptake and inhibition.

Cui D, Morris ME.

Drug Metab Dispos. 2009 Jul;37(7):1404-10. doi: 10.1124/dmd.109.027169. Epub 2009 Apr 23.

PMID:
19389857
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The clinical toxicology of γ-hydroxybutyrate, γ-butyrolactone and 1,4-butanediol.

Schep LJ, Knudsen K, Slaughter RJ, Vale JA, Mégarbane B.

Clin Toxicol (Phila). 2012 Jul;50(6):458-70. doi: 10.3109/15563650.2012.702218. Review.

PMID:
22746383
[PubMed - indexed for MEDLINE]
13.

Mechanistic modeling of monocarboxylate transporter-mediated toxicokinetic/toxicodynamic interactions between γ-hydroxybutyrate and L-lactate.

Morse BL, Vijay N, Morris ME.

AAPS J. 2014 Jul;16(4):756-70. doi: 10.1208/s12248-014-9593-8. Epub 2014 May 23.

PMID:
24854892
[PubMed - in process]
14.

Effect of 3,4-Methylenedioxymethamphetamine on the Toxicokinetics and Sedative Effects of the Drug of Abuse, γ-Hydroxybutyric Acid.

Vijay N, Morris ME.

J Pharm Sci. 2014 Aug 29. doi: 10.1002/jps.24122. [Epub ahead of print]

PMID:
25174723
[PubMed - as supplied by publisher]
15.

Monocarboxylate transporter (MCT) mediates the transport of gamma-hydroxybutyrate in human kidney HK-2 cells.

Wang Q, Lu Y, Morris ME.

Pharm Res. 2007 Jun;24(6):1067-78. Epub 2007 Mar 22.

PMID:
17377745
[PubMed - indexed for MEDLINE]
16.

GHB (gamma-hydroxybutyrate) carrier-mediated transport across the blood-brain barrier.

Bhattacharya I, Boje KM.

J Pharmacol Exp Ther. 2004 Oct;311(1):92-8. Epub 2004 Jun 1.

PMID:
15173314
[PubMed - indexed for MEDLINE]
Free Article
17.

Behavioral effects and pharmacokinetics of gamma-hydroxybutyrate (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons.

Goodwin AK, Brown PR, Jansen EE, Jakobs C, Gibson KM, Weerts EM.

Psychopharmacology (Berl). 2009 Jun;204(3):465-76. doi: 10.1007/s00213-009-1477-8. Epub 2009 Feb 6.

PMID:
19198808
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo.

Wang Q, Morris ME.

Drug Metab Dispos. 2007 Feb;35(2):201-8. Epub 2006 Nov 15.

PMID:
17108059
[PubMed - indexed for MEDLINE]
Free Article
19.

Comparative study of equimolar doses of gamma-hydroxybutyrate (GHB), 1,4-butanediol (1,4-BD) and gamma-butyrolactone (GBL) on catalepsy after acute and chronic administration.

Towiwat P, Phattanarudee S, Maher TJ.

Food Chem Toxicol. 2013 Jan;51:337-42. doi: 10.1016/j.fct.2012.10.009. Epub 2012 Oct 24.

PMID:
23104245
[PubMed - indexed for MEDLINE]
20.

Gamma butyrolactone (GBL) and gamma valerolactone (GVL): similarities and differences in their effects on the acoustic startle reflex and the conditioned enhancement of startle in the rat.

Marinetti LJ, Leavell BJ, Jones CM, Hepler BR, Isenschmid DS, Commissaris RL.

Pharmacol Biochem Behav. 2012 Jun;101(4):602-8. doi: 10.1016/j.pbb.2012.01.023. Epub 2012 Feb 12.

PMID:
22349589
[PubMed - indexed for MEDLINE]

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