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Results: 1 to 20 of 124

1.

Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice.

Walker JR, Pacoma R, Watson J, Ou W, Alves J, Mason DE, Peters EC, Urbina HD, Welzel G, Althage A, Liu B, Tuntland T, Jacobson LH, Harris JL, Schumacher AM.

J Neurosci. 2013 Feb 6;33(6):2457-64. doi: 10.1523/JNEUROSCI.3407-12.2013.

PMID:
23392674
[PubMed - indexed for MEDLINE]
Free Article
2.

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver.

Sehgal N, Gupta A, Valli RK, Joshi SD, Mills JT, Hamel E, Khanna P, Jain SC, Thakur SS, Ravindranath V.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3510-5. doi: 10.1073/pnas.1112209109. Epub 2012 Jan 30.

PMID:
22308347
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease.

Rockenstein E, Torrance M, Mante M, Adame A, Paulino A, Rose JB, Crews L, Moessler H, Masliah E.

J Neurosci Res. 2006 May 15;83(7):1252-61.

PMID:
16511867
[PubMed - indexed for MEDLINE]
4.

GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice.

Tian J, Shi J, Zhang L, Yin J, Hu Q, Xu Y, Sheng S, Wang P, Ren Y, Wang R, Wang Y.

Curr Alzheimer Res. 2009 Apr;6(2):118-31.

PMID:
19355846
[PubMed - indexed for MEDLINE]
5.

Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy.

Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ.

Am J Pathol. 2007 Jul;171(1):241-51.

PMID:
17591969
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Recombinant soluble neprilysin reduces amyloid-beta accumulation and improves memory impairment in Alzheimer's disease mice.

Park MH, Lee JK, Choi S, Ahn J, Jin HK, Park JS, Bae JS.

Brain Res. 2013 Sep 5;1529:113-24. doi: 10.1016/j.brainres.2013.05.045. Epub 2013 Jul 2.

PMID:
23831521
[PubMed - indexed for MEDLINE]
7.

Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

Marr RA, Rockenstein E, Mukherjee A, Kindy MS, Hersh LB, Gage FH, Verma IM, Masliah E.

J Neurosci. 2003 Mar 15;23(6):1992-6.

PMID:
12657655
[PubMed - indexed for MEDLINE]
Free Article
8.

4-O-methylhonokiol attenuated memory impairment through modulation of oxidative damage of enzymes involving amyloid-β generation and accumulation in a mouse model of Alzheimer's disease.

Choi IS, Lee YJ, Choi DY, Lee YK, Lee YH, Kim KH, Kim YH, Jeon YH, Kim EH, Han SB, Jung JK, Yun YP, Oh KW, Hwang DY, Hong JT.

J Alzheimers Dis. 2011;27(1):127-41. doi: 10.3233/JAD-2011-110545.

PMID:
21799245
[PubMed - indexed for MEDLINE]
9.

Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders.

Caccamo A, Oddo S, Sugarman MC, Akbari Y, LaFerla FM.

Neurobiol Aging. 2005 May;26(5):645-54.

PMID:
15708439
[PubMed - indexed for MEDLINE]
10.

p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain.

Wang YJ, Wang X, Lu JJ, Li QX, Gao CY, Liu XH, Sun Y, Yang M, Lim Y, Evin G, Zhong JH, Masters C, Zhou XF.

J Neurosci. 2011 Feb 9;31(6):2292-304. doi: 10.1523/JNEUROSCI.2733-10.2011.

PMID:
21307265
[PubMed - indexed for MEDLINE]
Free Article
11.

Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.

Li G, Percontino L, Sun Q, Qazi AS, Frederikse PH.

Mol Vis. 2003 May 1;9:179-83.

PMID:
12740567
[PubMed - indexed for MEDLINE]
Free Article
12.

Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology.

Fukami S, Watanabe K, Iwata N, Haraoka J, Lu B, Gerard NP, Gerard C, Fraser P, Westaway D, St George-Hyslop P, Saido TC.

Neurosci Res. 2002 May;43(1):39-56.

PMID:
12074840
[PubMed - indexed for MEDLINE]
13.

Convection-enhanced delivery of neprilysin: a novel amyloid-β-degrading therapeutic strategy.

Barua NU, Miners JS, Bienemann AS, Wyatt MJ, Welser K, Tabor AB, Hailes HC, Love S, Gill SS.

J Alzheimers Dis. 2012;32(1):43-56.

PMID:
22751177
[PubMed - indexed for MEDLINE]
14.

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ.

Neuron. 2003 Dec 18;40(6):1087-93.

PMID:
14687544
[PubMed - indexed for MEDLINE]
Free Article
15.

Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.

Hemming ML, Patterson M, Reske-Nielsen C, Lin L, Isacson O, Selkoe DJ.

PLoS Med. 2007 Aug;4(8):e262.

PMID:
17760499
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease.

Mohajeri MH, Kuehnle K, Li H, Poirier R, Tracy J, Nitsch RM.

FEBS Lett. 2004 Mar 26;562(1-3):16-21.

PMID:
15043995
[PubMed - indexed for MEDLINE]
Free Article
17.

Aβ-degrading enzymes: potential for treatment of Alzheimer disease.

Miners JS, Barua N, Kehoe PG, Gill S, Love S.

J Neuropathol Exp Neurol. 2011 Nov;70(11):944-59. doi: 10.1097/NEN.0b013e3182345e46. Review.

PMID:
22002425
[PubMed - indexed for MEDLINE]
18.

Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice.

Kawahara K, Suenobu M, Yoshida A, Koga K, Hyodo A, Ohtsuka H, Kuniyasu A, Tamamaki N, Sugimoto Y, Nakayama H.

Neuroscience. 2012 Apr 5;207:243-60. doi: 10.1016/j.neuroscience.2012.01.049. Epub 2012 Feb 7.

PMID:
22342341
[PubMed - indexed for MEDLINE]
19.

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

Iwata N, Mizukami H, Shirotani K, Takaki Y, Muramatsu S, Lu B, Gerard NP, Gerard C, Ozawa K, Saido TC.

J Neurosci. 2004 Jan 28;24(4):991-8.

PMID:
14749444
[PubMed - indexed for MEDLINE]
Free Article
20.

Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease.

Guan H, Liu Y, Daily A, Police S, Kim MH, Oddo S, LaFerla FM, Pauly JR, Murphy MP, Hersh LB.

J Neurosci Res. 2009 May 1;87(6):1462-73. doi: 10.1002/jnr.21944.

PMID:
19021293
[PubMed - indexed for MEDLINE]
Free PMC Article

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