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DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.

Kondo T, Kobayashi J, Saitoh T, Maruyama K, Ishii KJ, Barber GN, Komatsu K, Akira S, Kawai T.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2969-74. doi: 10.1073/pnas.1222694110. Epub 2013 Feb 6.


Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.

Lee JH, Mand MR, Deshpande RA, Kinoshita E, Yang SH, Wyman C, Paull TT.

J Biol Chem. 2013 May 3;288(18):12840-51. doi: 10.1074/jbc.M113.460378. Epub 2013 Mar 22.


The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.

Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH.

Genes Dev. 2005 Dec 15;19(24):3043-54.


ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.

Lee JH, Paull TT.

Science. 2005 Apr 22;308(5721):551-4. Epub 2005 Mar 24. Erratum in: Science. 2005 Jun 24;308(5730):1870.


Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

Williams RS, Williams JS, Tainer JA.

Biochem Cell Biol. 2007 Aug;85(4):509-20. Review.


Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.

Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y.

J Biol Chem. 2006 Oct 13;281(41):30814-23. Epub 2006 Aug 10.


The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation.

Yu Z, Vogel G, Coulombe Y, Dubeau D, Spehalski E, H├ębert J, Ferguson DO, Masson JY, Richard S.

Cell Res. 2012 Feb;22(2):305-20. doi: 10.1038/cr.2011.128. Epub 2011 Aug 9.


A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner.

Wen Q, Scorah J, Phear G, Rodgers G, Rodgers S, Meuth M.

Mol Biol Cell. 2008 Apr;19(4):1693-705. doi: 10.1091/mbc.E07-09-0975. Epub 2008 Feb 6.


Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.

Cerosaletti K, Concannon P.

J Biol Chem. 2004 Sep 10;279(37):38813-9. Epub 2004 Jul 1.


Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.

He J, Shi LZ, Truong LN, Lu CS, Razavian N, Li Y, Negrete A, Shiloach J, Berns MW, Wu X.

J Biol Chem. 2012 Sep 14;287(38):31747-56. doi: 10.1074/jbc.M112.384750. Epub 2012 Jul 25.


Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11.

Chen C, Zhang L, Huang NJ, Huang B, Kornbluth S.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20605-10. doi: 10.1073/pnas.1306328110. Epub 2013 Dec 2.


Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.

Limbo O, Moiani D, Kertokalio A, Wyman C, Tainer JA, Russell P.

Nucleic Acids Res. 2012 Dec;40(22):11435-49. doi: 10.1093/nar/gks954. Epub 2012 Oct 17.


Role of mammalian Mre11 in classical and alternative nonhomologous end joining.

Xie A, Kwok A, Scully R.

Nat Struct Mol Biol. 2009 Aug;16(8):814-8. doi: 10.1038/nsmb.1640. Epub 2009 Jul 26.


PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin.

Di Virgilio M, Ying CY, Gautier J.

DNA Repair (Amst). 2009 Nov 2;8(11):1311-20. doi: 10.1016/j.dnarep.2009.07.006. Epub 2009 Aug 25.


Activation and regulation of ATM kinase activity in response to DNA double-strand breaks.

Lee JH, Paull TT.

Oncogene. 2007 Dec 10;26(56):7741-8. Review.


Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation.

Buis J, Wu Y, Deng Y, Leddon J, Westfield G, Eckersdorff M, Sekiguchi JM, Chang S, Ferguson DO.

Cell. 2008 Oct 3;135(1):85-96. doi: 10.1016/j.cell.2008.08.015.


Activation of ataxia telangiectasia-mutated DNA damage checkpoint signal transduction elicited by herpes simplex virus infection.

Shirata N, Kudoh A, Daikoku T, Tatsumi Y, Fujita M, Kiyono T, Sugaya Y, Isomura H, Ishizaki K, Tsurumi T.

J Biol Chem. 2005 Aug 26;280(34):30336-41. Epub 2005 Jun 17.

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