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Results: 1 to 20 of 126

1.

Sodium valproate alleviates neurodegeneration in SCA3/MJD via suppressing apoptosis and rescuing the hypoacetylation levels of histone H3 and H4.

Yi J, Zhang L, Tang B, Han W, Zhou Y, Chen Z, Jia D, Jiang H.

PLoS One. 2013;8(1):e54792. doi: 10.1371/journal.pone.0054792. Epub 2013 Jan 28.

PMID:
23382971
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3.

Chou AH, Chen SY, Yeh TH, Weng YH, Wang HL.

Neurobiol Dis. 2011 Feb;41(2):481-8. doi: 10.1016/j.nbd.2010.10.019. Epub 2010 Nov 1.

PMID:
21047555
[PubMed - indexed for MEDLINE]
3.

Lithium chloride alleviates neurodegeneration partly by inhibiting activity of GSK3β in a SCA3 Drosophila model.

Jia DD, Zhang L, Chen Z, Wang CR, Huang FZ, Duan RH, Xia K, Tang BS, Jiang H.

Cerebellum. 2013 Dec;12(6):892-901. doi: 10.1007/s12311-013-0498-3.

PMID:
23812869
[PubMed - indexed for MEDLINE]
4.

Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro.

Chai Y, Koppenhafer SL, Shoesmith SJ, Perez MK, Paulson HL.

Hum Mol Genet. 1999 Apr;8(4):673-82.

PMID:
10072437
[PubMed - indexed for MEDLINE]
Free Article
5.

Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila.

McGurk L, Bonini NM.

Hum Mol Genet. 2012 Jan 1;21(1):76-84. doi: 10.1093/hmg/ddr439. Epub 2011 Sep 23.

PMID:
21949352
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Time- and residue-specific differences in histone acetylation induced by VPA and SAHA in AML1/ETO-positive leukemia cells.

Barbetti V, Gozzini A, Cheloni G, Marzi I, Fabiani E, Santini V, Dello Sbarba P, Rovida E.

Epigenetics. 2013 Feb;8(2):210-9. doi: 10.4161/epi.23538. Epub 2013 Jan 15. Erratum in: Epigenetics. 2013 Dec;8(12):1384.

PMID:
23321683
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Toward understanding Machado-Joseph disease.

Costa Mdo C, Paulson HL.

Prog Neurobiol. 2012 May;97(2):239-57. doi: 10.1016/j.pneurobio.2011.11.006. Epub 2011 Nov 23. Review.

PMID:
22133674
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Targeting AML1/ETO-histone deacetylase repressor complex: a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cells.

Liu S, Klisovic RB, Vukosavljevic T, Yu J, Paschka P, Huynh L, Pang J, Neviani P, Liu Z, Blum W, Chan KK, Perrotti D, Marcucci G.

J Pharmacol Exp Ther. 2007 Jun;321(3):953-60. Epub 2007 Mar 26.

PMID:
17389244
[PubMed - indexed for MEDLINE]
Free Article
9.

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.

Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, Kazantsev A, Schmidt E, Zhu YZ, Greenwald M, Kurokawa R, Housman DE, Jackson GR, Marsh JL, Thompson LM.

Nature. 2001 Oct 18;413(6857):739-43.

PMID:
11607033
[PubMed - indexed for MEDLINE]
10.

Expression of expanded polyglutamine protein induces behavioral changes in Drosophila (polyglutamine-induced changes in Drosophila).

Kim YT, Shin SM, Lee WY, Kim GM, Jin DK.

Cell Mol Neurobiol. 2004 Feb;24(1):109-22.

PMID:
15049515
[PubMed - indexed for MEDLINE]
11.

Polyglutamine-expanded ataxin-3 impairs long-term depression in Purkinje neurons of SCA3 transgenic mouse by inhibiting HAT and impairing histone acetylation.

Chou AH, Chen YL, Hu SH, Chang YM, Wang HL.

Brain Res. 2014 Aug 17. pii: S0006-8993(14)01083-X. doi: 10.1016/j.brainres.2014.08.019. [Epub ahead of print]

PMID:
25139423
[PubMed - as supplied by publisher]
12.

A proapoptotic effect of valproic acid on progenitors of embryonic stem cell-derived glutamatergic neurons.

Fujiki R, Sato A, Fujitani M, Yamashita T.

Cell Death Dis. 2013 Jun 20;4:e677. doi: 10.1038/cddis.2013.205.

PMID:
23788034
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Hepatoprotection and lethality rescue by histone deacetylase inhibitor valproic acid in fatal hemorrhagic shock.

Gonzales ER, Chen H, Munuve RM, Mehrani T, Nadel A, Koustova E.

J Trauma. 2008 Sep;65(3):554-65. doi: 10.1097/TA.0b013e31818233ef.

PMID:
18784568
[PubMed - indexed for MEDLINE]
14.

[Inhibitory effect of VPA on multiple myeloma U266 cell proliferation and regulation of histone acetylation].

Zhu YF, Ye BG, Shen JZ, Lin CM, Lin FA, Shen SF, Xu CB.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Jun;18(3):638-41. Chinese.

PMID:
20561418
[PubMed - indexed for MEDLINE]
15.

Valproic acid attenuates the suppression of acetyl histone H3 and CREB activity in an inducible cell model of Machado-Joseph disease.

Lin XP, Feng L, Xie CG, Chen DB, Pei Z, Liang XL, Xie QY, Li XH, Pan SY.

Int J Dev Neurosci. 2014 Jul 25;38C:17-22. doi: 10.1016/j.ijdevneu.2014.07.004. [Epub ahead of print]

PMID:
25068645
[PubMed - as supplied by publisher]
16.

Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni.

Dubois F, Caby S, Oger F, Cosseau C, Capron M, Grunau C, Dissous C, Pierce RJ.

Mol Biochem Parasitol. 2009 Nov;168(1):7-15. doi: 10.1016/j.molbiopara.2009.06.001. Epub 2009 Jun 16.

PMID:
19538992
[PubMed - indexed for MEDLINE]
17.

Polyglutamine-induced neurodegeneration in SCA3 is not mitigated by non-expanded ataxin-3: conclusions from double-transgenic mouse models.

Hübener J, Riess O.

Neurobiol Dis. 2010 Apr;38(1):116-24. doi: 10.1016/j.nbd.2010.01.005. Epub 2010 Jan 15.

PMID:
20079840
[PubMed - indexed for MEDLINE]
18.

Valproic acid-mediated neuroprotection in retinal ischemia injury via histone deacetylase inhibition and transcriptional activation.

Zhang Z, Qin X, Tong N, Zhao X, Gong Y, Shi Y, Wu X.

Exp Eye Res. 2012 Jan;94(1):98-108. doi: 10.1016/j.exer.2011.11.013. Epub 2011 Nov 28.

PMID:
22143029
[PubMed - indexed for MEDLINE]
19.

Prevention of hypoxia-induced neuronal apoptosis through histone deacetylase inhibition.

Li Y, Yuan Z, Liu B, Sailhamer EA, Shults C, Velmahos GC, Demoya M, Alam HB.

J Trauma. 2008 Apr;64(4):863-70; discussion 870-1. doi: 10.1097/TA.0b013e318166b822.

PMID:
18404049
[PubMed - indexed for MEDLINE]
20.

SUMO-1 modification on K166 of polyQ-expanded ataxin-3 strengthens its stability and increases its cytotoxicity.

Zhou YF, Liao SS, Luo YY, Tang JG, Wang JL, Lei LF, Chi JW, Du J, Jiang H, Xia K, Tang BS, Shen L.

PLoS One. 2013;8(1):e54214. doi: 10.1371/journal.pone.0054214. Epub 2013 Jan 31.

PMID:
23382880
[PubMed - indexed for MEDLINE]
Free PMC Article

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