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Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly.

Selimyan R, Gerstein RM, Ivanova I, Precht P, Subrahmanyam R, Perlot T, Alt FW, Sen R.

PLoS Biol. 2013;11(1):e1001475. doi: 10.1371/journal.pbio.1001475. Epub 2013 Jan 29.


Insertion of an imprinted insulator into the IgH locus reveals developmentally regulated, transcription-dependent control of V(D)J recombination.

Puget N, Hirasawa R, Hu NS, Laviolette-Malirat N, Feil R, Khamlichi AA.

Mol Cell Biol. 2015 Feb;35(3):529-43. doi: 10.1128/MCB.00235-14. Epub 2014 Nov 17.


Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.

Giallourakis CC, Franklin A, Guo C, Cheng HL, Yoon HS, Gallagher M, Perlot T, Andzelm M, Murphy AJ, Macdonald LE, Yancopoulos GD, Alt FW.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22207-12. doi: 10.1073/pnas.1015954107. Epub 2010 Dec 1.


Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions.

Subrahmanyam R, Du H, Ivanova I, Chakraborty T, Ji Y, Zhang Y, Alt FW, Schatz DG, Sen R.

Nat Immunol. 2012 Dec;13(12):1205-12. doi: 10.1038/ni.2447. Epub 2012 Oct 28.


CTCF-binding elements mediate control of V(D)J recombination.

Guo C, Yoon HS, Franklin A, Jain S, Ebert A, Cheng HL, Hansen E, Despo O, Bossen C, Vettermann C, Bates JG, Richards N, Myers D, Patel H, Gallagher M, Schlissel MS, Murre C, Busslinger M, Giallourakis CC, Alt FW.

Nature. 2011 Sep 11;477(7365):424-30. doi: 10.1038/nature10495.


Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments.

Hesslein DG, Pflugh DL, Chowdhury D, Bothwell AL, Sen R, Schatz DG.

Genes Dev. 2003 Jan 1;17(1):37-42.


Deletion of the DQ52 element within the Ig heavy chain locus leads to a selective reduction in VDJ recombination and altered D gene usage.

Nitschke L, Kestler J, Tallone T, Pelkonen S, Pelkonen J.

J Immunol. 2001 Feb 15;166(4):2540-52.


The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombination.

Featherstone K, Wood AL, Bowen AJ, Corcoran AE.

J Biol Chem. 2010 Mar 26;285(13):9327-38. doi: 10.1074/jbc.M109.098251. Epub 2010 Jan 25.


Two forms of loops generate the chromatin conformation of the immunoglobulin heavy-chain gene locus.

Guo C, Gerasimova T, Hao H, Ivanova I, Chakraborty T, Selimyan R, Oltz EM, Sen R.

Cell. 2011 Oct 14;147(2):332-43. doi: 10.1016/j.cell.2011.08.049. Epub 2011 Oct 6.


Regulation of IgH gene assembly: role of the intronic enhancer and 5'DQ52 region in targeting DHJH recombination.

Afshar R, Pierce S, Bolland DJ, Corcoran A, Oltz EM.

J Immunol. 2006 Feb 15;176(4):2439-47.


Chromatin remodeling at the Ig loci prior to V(D)J recombination.

Maës J, O'Neill LP, Cavelier P, Turner BM, Rougeon F, Goodhardt M.

J Immunol. 2001 Jul 15;167(2):866-74.


Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation.

Kuzin II, Bagaeva L, Young FM, Bottaro A.

J Immunol. 2008 Jun 1;180(11):7443-50.


Repeat organization and epigenetic regulation of the DH-Cmu domain of the immunoglobulin heavy-chain gene locus.

Chakraborty T, Chowdhury D, Keyes A, Jani A, Subrahmanyam R, Ivanova I, Sen R.

Mol Cell. 2007 Sep 7;27(5):842-50.


Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.

Jung D, Giallourakis C, Mostoslavsky R, Alt FW.

Annu Rev Immunol. 2006;24:541-70. Review.


Association between the Igk and Igh immunoglobulin loci mediated by the 3' Igk enhancer induces 'decontraction' of the Igh locus in pre-B cells.

Hewitt SL, Farmer D, Marszalek K, Cadera E, Liang HE, Xu Y, Schlissel MS, Skok JA.

Nat Immunol. 2008 Apr;9(4):396-404. doi: 10.1038/ni1567. Epub 2008 Feb 24.


The Eμ enhancer region influences H chain expression and B cell fate without impacting IgVH repertoire and immune response in vivo.

Marquet M, Garot A, Bender S, Carrion C, Rouaud P, Lecardeur S, Denizot Y, Cogné M, Pinaud E.

J Immunol. 2014 Aug 1;193(3):1171-83. doi: 10.4049/jimmunol.1302868. Epub 2014 Jun 25.


Complete cis Exclusion upon Duplication of the Eμ Enhancer at the Immunoglobulin Heavy Chain Locus.

Puget N, Leduc C, Oruc Z, Moutahir M, Le Bert M, Khamlichi AA.

Mol Cell Biol. 2015 Jul;35(13):2231-41.


Large-scale chromatin remodeling at the immunoglobulin heavy chain locus: a paradigm for multigene regulation.

Bolland DJ, Wood AL, Corcoran AE.

Adv Exp Med Biol. 2009;650:59-72. Review.

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