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RNA-sequencing quantification of hepatic ontogeny and tissue distribution of mRNAs of phase II enzymes in mice.

Lu H, Gunewardena S, Cui JY, Yoo B, Zhong XB, Klaassen CD.

Drug Metab Dispos. 2013 Apr;41(4):844-57. doi: 10.1124/dmd.112.050211. Epub 2013 Feb 4.


Hepatic ontogeny and tissue distribution of mRNAs of epigenetic modifiers in mice using RNA-sequencing.

Lu H, Cui JY, Gunewardena S, Yoo B, Zhong XB, Klaassen CD.

Epigenetics. 2012 Aug;7(8):914-29. doi: 10.4161/epi.21113. Epub 2012 Jul 9.


Tissue distribution and ontogeny of sulfotransferase enzymes in mice.

Alnouti Y, Klaassen CD.

Toxicol Sci. 2006 Oct;93(2):242-55. Epub 2006 Jun 28.


Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha.

Lu H, Gonzalez FJ, Klaassen C.

Toxicol Sci. 2010 Dec;118(2):380-90. doi: 10.1093/toxsci/kfq280. Epub 2010 Oct 8.


Regulation of hepatic phase II metabolism in pregnant mice.

Wen X, Donepudi AC, Thomas PE, Slitt AL, King RS, Aleksunes LM.

J Pharmacol Exp Ther. 2013 Jan;344(1):244-52. doi: 10.1124/jpet.112.199034. Epub 2012 Oct 10.


Short-term calorie restriction feminizes the mRNA profiles of drug metabolizing enzymes and transporters in livers of mice.

Fu ZD, Klaassen CD.

Toxicol Appl Pharmacol. 2014 Jan 1;274(1):137-46. doi: 10.1016/j.taap.2013.11.003. Epub 2013 Nov 13.


Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPAR╬▒-, and Nrf2-null mice.

Aleksunes LM, Klaassen CD.

Drug Metab Dispos. 2012 Jul;40(7):1366-79. doi: 10.1124/dmd.112.045112. Epub 2012 Apr 11.


RNA-sequencing quantification of hepatic ontogeny of phase-I enzymes in mice.

Peng L, Cui JY, Yoo B, Gunewardena SS, Lu H, Klaassen CD, Zhong XB.

Drug Metab Dispos. 2013 Dec;41(12):2175-86. doi: 10.1124/dmd.113.054635. Epub 2013 Sep 30.


Genetic and epigenetic regulation and expression signatures of glutathione S-transferases in developing mouse liver.

Cui JY, Choudhuri S, Knight TR, Klaassen CD.

Toxicol Sci. 2010 Jul;116(1):32-43. doi: 10.1093/toxsci/kfq115. Epub 2010 Apr 15.


Energy restriction does not compensate for the reduced expression of hepatic drug-processing genes in mice with aging.

Zhang YK, Saupe KW, Klaassen CD.

Drug Metab Dispos. 2010 Jul;38(7):1122-31. doi: 10.1124/dmd.110.032599. Epub 2010 Apr 9.


UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis.

Xu J, Kulkarni SR, Li L, Slitt AL.

Drug Metab Dispos. 2012 Feb;40(2):259-66. doi: 10.1124/dmd.111.039925. Epub 2011 Oct 26.


RNA sequencing reveals dynamic changes of mRNA abundance of cytochromes P450 and their alternative transcripts during mouse liver development.

Peng L, Yoo B, Gunewardena SS, Lu H, Klaassen CD, Zhong XB.

Drug Metab Dispos. 2012 Jun;40(6):1198-209. doi: 10.1124/dmd.112.045088. Epub 2012 Mar 20.


Ontogeny of hepatic energy metabolism genes in mice as revealed by RNA-sequencing.

Renaud HJ, Cui YJ, Lu H, Zhong XB, Klaassen CD.

PLoS One. 2014 Aug 7;9(8):e104560. doi: 10.1371/journal.pone.0104560. eCollection 2014.


Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver.

Wu KC, Cui JY, Klaassen CD.

PLoS One. 2012;7(7):e39006. doi: 10.1371/journal.pone.0039006. Epub 2012 Jul 12.


RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development.

Cui JY, Gunewardena SS, Yoo B, Liu J, Renaud HJ, Lu H, Zhong XB, Klaassen CD.

Toxicol Sci. 2012 Jun;127(2):592-608. doi: 10.1093/toxsci/kfs107. Epub 2012 Mar 27.


Regulation of phase II biotransformation enzymes by steroid hormones.

Kohalmy K, Vrzal R.

Curr Drug Metab. 2011 Feb;12(2):104-23. Review.


Induction of phase I, II and III drug metabolism/transport by xenobiotics.

Xu C, Li CY, Kong AN.

Arch Pharm Res. 2005 Mar;28(3):249-68. Review.


Expression of arginase II and related enzymes in the rat small intestine and kidney.

Ozaki M, Gotoh T, Nagasaki A, Miyanaka K, Takeya M, Fujiyama S, Tomita K, Mori M.

J Biochem. 1999 Mar;125(3):586-93.


Development and regulation of glucose-6-phosphatase gene expression in rat liver, intestine, and kidney: in vivo and in vitro studies in cultured fetal hepatocytes.

Chatelain F, P├ęgorier JP, Minassian C, Bruni N, Tarpin S, Girard J, Mithieux G.

Diabetes. 1998 Jun;47(6):882-9.

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