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Effects of SEA0400 on arrhythmogenicity in a Langendorff-perfused 1-month myocardial infarction rabbit model.

Chou CC, Chang PC, Wen MS, Lee HL, Chu Y, Baba A, Matsuda T, Yeh SJ, Wu D.

Pacing Clin Electrophysiol. 2013 May;36(5):596-606. doi: 10.1111/pace.12091. Epub 2013 Feb 4.


Blunted proarrhythmic effect of nicorandil in a Langendorff-perfused phase-2 myocardial infarction rabbit model.

Lee HL, Chang PC, Chou CC, Wo HT, Chu Y, Wen MS, Yeh SJ, Wu D.

Pacing Clin Electrophysiol. 2013 Feb;36(2):142-51. doi: 10.1111/pace.12029. Epub 2012 Nov 4.


Contrasting effects of HMR1098 on arrhythmogenicity in a Langendorff-perfused phase-2 myocardial infarction rabbit model.

Lee HL, Lu CH, Chang PC, Chou CC, Wo HT, Wen MS.

Pacing Clin Electrophysiol. 2014 Aug;37(8):1058-66. doi: 10.1111/pace.12381. Epub 2014 Mar 20.


Effects of dantrolene on arrhythmogenicity in isolated regional ischemia-reperfusion rabbit hearts with or without pacing-induced heart failure.

Chou CC, Lee HL, Chang PC, Wo HT, Wen MS, Yeh SJ.

Biomed Res Int. 2015;2015:532820. doi: 10.1155/2015/532820. Epub 2015 Feb 19.


Dantrolene suppresses ventricular ectopy and arrhythmogenicity with acute myocardial infarction in a langendorff-perfused pacing-induced heart failure rabbit model.

Chou CC, Wen MS, Lee HL, Chang PC, Wo HT, Yeh SJ, Wu D.

J Cardiovasc Electrophysiol. 2014 Apr;25(4):431-9. doi: 10.1111/jce.12320. Epub 2013 Dec 9.


Comparison of the efficiency of Na+/Ca2+ exchanger or Na+/H+ exchanger inhibition and their combination in reducing coronary reperfusion-induced arrhythmias.

Szepesi J, Acsai K, Sebok Z, Prorok J, Pollesello P, Levijoki J, Papp JG, Varro A, Toth A.

J Physiol Pharmacol. 2015 Apr;66(2):215-26.


Paradoxical effects of KB-R7943 on arrhythmogenicity in a chronic myocardial infarction rabbit model.

Chang PC, Wo HT, Lee HL, Wen MS, Chou CC.

J Cardiol. 2015 Jul;66(1):80-7. doi: 10.1016/j.jjcc.2014.08.002. Epub 2014 Sep 16.


Piceatannol facilitates conduction block and ventricular fibrillation induction in ischemia-reperfused rabbit hearts with pacing-induced heart failure.

Chou CC, Chang PC, Wen MS, Lee HL, Wo HT, Yeh SJ, Wu D.

Int J Cardiol. 2014 Feb 1;171(2):250-8. doi: 10.1016/j.ijcard.2013.12.033. Epub 2013 Dec 22.


Differing cardioprotective efficacy of the Na+/Ca2+ exchanger inhibitors SEA0400 and KB-R7943.

Magee WP, Deshmukh G, Deninno MP, Sutt JC, Chapman JG, Tracey WR.

Am J Physiol Heart Circ Physiol. 2003 Mar;284(3):H903-10. Epub 2002 Nov 21.


SEA0400 fails to alter the magnitude of intracellular Ca2+ transients and contractions in Langendorff-perfused guinea pig heart.

Szentandrássy N, Birinyi P, Szigeti G, Farkas A, Magyar J, Tóth A, Csernoch L, Varró A, Nánási PP.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):65-71. doi: 10.1007/s00210-008-0296-5. Epub 2008 May 6.


Inhibition of the sodium-calcium exchanger via SEA0400 altered manganese-induced T1 changes in isolated perfused rat hearts.

Chen Y, Payne K, Perara VS, Huang S, Baba A, Matsuda T, Yu X.

NMR Biomed. 2012 Nov;25(11):1280-5. doi: 10.1002/nbm.2799. Epub 2012 Mar 21.


Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3.

Milberg P, Pott C, Fink M, Frommeyer G, Matsuda T, Baba A, Osada N, Breithardt G, Noble D, Eckardt L.

Heart Rhythm. 2008 Oct;5(10):1444-52. doi: 10.1016/j.hrthm.2008.06.017. Epub 2008 Jun 28.


Protective effects of SEA0400, a novel and selective inhibitor of the Na+/Ca2+ exchanger, on myocardial ischemia-reperfusion injuries.

Takahashi K, Takahashi T, Suzuki T, Onishi M, Tanaka Y, Hamano-Takahashi A, Ota T, Kameo K, Matsuda T, Baba A.

Eur J Pharmacol. 2003 Jan 1;458(1-2):155-62.


Remodelling of action potential and intracellular calcium cycling dynamics during subacute myocardial infarction promotes ventricular arrhythmias in Langendorff-perfused rabbit hearts.

Chou CC, Zhou S, Hayashi H, Nihei M, Liu YB, Wen MS, Yeh SJ, Fishbein MC, Weiss JN, Lin SF, Wu D, Chen PS.

J Physiol. 2007 May 1;580(Pt.3):895-906. Epub 2007 Feb 1.


A selective inhibitor of Na+/Ca2+ exchanger, SEA0400, preserves cardiac function and high-energy phosphates against ischemia/reperfusion injury.

Feng NC, Satoh H, Urushida T, Katoh H, Terada H, Watanabe Y, Hayashi H.

J Cardiovasc Pharmacol. 2006 Feb;47(2):263-70.


Selective Na(+) /Ca(2+) exchanger inhibition prevents Ca(2+) overload-induced triggered arrhythmias.

Nagy N, Kormos A, Kohajda Z, Szebeni Á, Szepesi J, Pollesello P, Levijoki J, Acsai K, Virág L, Nánási PP, Papp JG, Varró A, Tóth A.

Br J Pharmacol. 2014 Dec;171(24):5665-81. doi: 10.1111/bph.12867.


Burst emergence of intracellular Ca2+ waves evokes arrhythmogenic oscillatory depolarization via the Na+-Ca2+ exchanger: simultaneous confocal recording of membrane potential and intracellular Ca2+ in the heart.

Fujiwara K, Tanaka H, Mani H, Nakagami T, Takamatsu T.

Circ Res. 2008 Aug 29;103(5):509-18. doi: 10.1161/CIRCRESAHA.108.176677. Epub 2008 Jul 17.


The Na+/Ca2+ exchange blocker SEA0400 fails to enhance cytosolic Ca2+ transient and contractility in canine ventricular cardiomyocytes.

Birinyi P, Tóth A, Jóna I, Acsai K, Almássy J, Nagy N, Prorok J, Gherasim I, Papp Z, Hertelendi Z, Szentandrássy N, Bányász T, Fülöp F, Papp JG, Varró A, Nánási PP, Magyar J.

Cardiovasc Res. 2008 Jun 1;78(3):476-84. doi: 10.1093/cvr/cvn031. Epub 2008 Feb 5.

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