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Methylglyoxal-induced cytotoxicity in neonatal rat brain: a role for oxidative stress and MAP kinases.

Heimfarth L, Loureiro SO, Pierozan P, de Lima BO, Reis KP, Torres EB, Pessoa-Pureur R.

Metab Brain Dis. 2013 Sep;28(3):429-38. doi: 10.1007/s11011-013-9379-1. Epub 2013 Feb 2.


LR-90 prevents methylglyoxal-induced oxidative stress and apoptosis in human endothelial cells.

Figarola JL, Singhal J, Rahbar S, Awasthi S, Singhal SS.

Apoptosis. 2014 May;19(5):776-88. doi: 10.1007/s10495-014-0974-3.


Methylglyoxal enhances cisplatin-induced cytotoxicity by activating protein kinase Cdelta.

Godbout JP, Pesavento J, Hartman ME, Manson SR, Freund GG.

J Biol Chem. 2002 Jan 25;277(4):2554-61. Epub 2001 Nov 13.


Apoptosis induced by the monomers HEMA and TEGDMA involves formation of ROS and differential activation of the MAP-kinases p38, JNK and ERK.

Samuelsen JT, Dahl JE, Karlsson S, Morisbak E, Becher R.

Dent Mater. 2007 Jan;23(1):34-9. Epub 2006 Jan 23.


Antioxidants inhibit JNK and p38 MAPK activation but not ERK 1/2 activation by angiotensin II in rat aortic smooth muscle cells.

Kyaw M, Yoshizumi M, Tsuchiya K, Kirima K, Tamaki T.

Hypertens Res. 2001 May;24(3):251-61.


Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.

Ou YC, Yang CR, Cheng CL, Raung SL, Hung YY, Chen CJ.

Eur J Pharmacol. 2007 Jun 1;563(1-3):49-60. Epub 2007 Feb 8.


Edaravone protected human brain microvascular endothelial cells from methylglyoxal-induced injury by inhibiting AGEs/RAGE/oxidative stress.

Li W, Xu H, Hu Y, He P, Ni Z, Xu H, Zhang Z, Dai H.

PLoS One. 2013 Sep 30;8(9):e76025. doi: 10.1371/journal.pone.0076025. eCollection 2013.


Low concentration of arsenic could induce caspase-3 mediated head kidney macrophage apoptosis with JNK-p38 activation in Clarias batrachus.

Datta S, Mazumder S, Ghosh D, Dey S, Bhattacharya S.

Toxicol Appl Pharmacol. 2009 Dec 15;241(3):329-38. doi: 10.1016/j.taap.2009.09.007. Epub 2009 Sep 24.


Angiotensin II-induced oxidative stress resets the Ca2+ dependence of Ca2+-calmodulin protein kinase II and promotes a death pathway conserved across different species.

Palomeque J, Rueda OV, Sapia L, Valverde CA, Salas M, Petroff MV, Mattiazzi A.

Circ Res. 2009 Dec 4;105(12):1204-12. doi: 10.1161/CIRCRESAHA.109.204172. Epub 2009 Oct 22.


Cadmium induces apoptosis in pancreatic β-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated c-Jun N-terminal kinase activation.

Chang KC, Hsu CC, Liu SH, Su CC, Yen CC, Lee MJ, Chen KL, Ho TJ, Hung DZ, Wu CC, Lu TH, Su YC, Chen YW, Huang CF.

PLoS One. 2013;8(2):e54374. doi: 10.1371/journal.pone.0054374. Epub 2013 Feb 6.


Methylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cells.

Yamawaki H, Saito K, Okada M, Hara Y.

Am J Physiol Cell Physiol. 2008 Dec;295(6):C1510-7. doi: 10.1152/ajpcell.00252.2008. Epub 2008 Oct 8.


Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases.

Caughlan A, Newhouse K, Namgung U, Xia Z.

Toxicol Sci. 2004 Mar;78(1):125-34. Epub 2003 Dec 22.


Role of oxidative stress and JNK pathway in apoptotic death induced by potassium deprivation and staurosporine in cerebellar granule neurons.

Ramiro-Cortés Y, Morán J.

Neurochem Int. 2009 Dec;55(7):581-92. doi: 10.1016/j.neuint.2009.05.015. Epub 2009 May 30.


Differential activation of mitogen-activated protein kinases in smooth muscle cells by angiotensin II: involvement of p22phox and reactive oxygen species.

Viedt C, Soto U, Krieger-Brauer HI, Fei J, Elsing C, Kübler W, Kreuzer J.

Arterioscler Thromb Vasc Biol. 2000 Apr;20(4):940-8.


Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells.

Seo SR, Chong SA, Lee SI, Sung JY, Ahn YS, Chung KC, Seo JT.

J Neurochem. 2001 Aug;78(3):600-10.


Genistein protects methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells.

Wu HJ, Chan WH.

Toxicol In Vitro. 2007 Apr;21(3):335-42. Epub 2006 Sep 14.


Cytoprotection by almond skin extracts or catechins of hepatocyte cytotoxicity induced by hydroperoxide (oxidative stress model) versus glyoxal or methylglyoxal (carbonylation model).

Dong Q, Banaich MS, O'Brien PJ.

Chem Biol Interact. 2010 Apr 29;185(2):101-9. doi: 10.1016/j.cbi.2010.03.003. Epub 2010 Mar 6.


Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway.

Chen L, Liu L, Yin J, Luo Y, Huang S.

Int J Biochem Cell Biol. 2009 Jun;41(6):1284-95. doi: 10.1016/j.biocel.2008.10.029. Epub 2008 Nov 6.

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