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Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex.

Makino DL, Baumgärtner M, Conti E.

Nature. 2013 Mar 7;495(7439):70-5. doi: 10.1038/nature11870. Epub 2013 Feb 3.


RNA degradation paths in a 12-subunit nuclear exosome complex.

Makino DL, Schuch B, Stegmann E, Baumgärtner M, Basquin C, Conti E.

Nature. 2015 Aug 6;524(7563):54-8. doi: 10.1038/nature14865. Epub 2015 Jul 29.


Exo- and endoribonucleolytic activities of yeast cytoplasmic and nuclear RNA exosomes are dependent on the noncatalytic core and central channel.

Wasmuth EV, Lima CD.

Mol Cell. 2012 Oct 12;48(1):133-44. doi: 10.1016/j.molcel.2012.07.012. Epub 2012 Aug 16.


Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA.

Wasmuth EV, Januszyk K, Lima CD.

Nature. 2014 Jul 24;511(7510):435-9. doi: 10.1038/nature13406. Epub 2014 Jul 6.


The yeast exosome functions as a macromolecular cage to channel RNA substrates for degradation.

Bonneau F, Basquin J, Ebert J, Lorentzen E, Conti E.

Cell. 2009 Oct 30;139(3):547-59. doi: 10.1016/j.cell.2009.08.042.


Threading the barrel of the RNA exosome.

Schneider C, Tollervey D.

Trends Biochem Sci. 2013 Oct;38(10):485-93. doi: 10.1016/j.tibs.2013.06.013. Epub 2013 Aug 2. Review.


The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome.

Schneider C, Leung E, Brown J, Tollervey D.

Nucleic Acids Res. 2009 Mar;37(4):1127-40. doi: 10.1093/nar/gkn1020. Epub 2009 Jan 7.


Structure determination of an 11-subunit exosome in complex with RNA by molecular replacement.

Makino DL, Conti E.

Acta Crystallogr D Biol Crystallogr. 2013 Nov;69(Pt 11):2226-35. doi: 10.1107/S0907444913011438. Epub 2013 Oct 12.


Modulating the RNA processing and decay by the exosome: altering Rrp44/Dis3 activity and end-product.

Reis FP, Barbas A, Klauer-King AA, Tsanova B, Schaeffer D, López-Viñas E, Gómez-Puertas P, van Hoof A, Arraiano CM.

PLoS One. 2013 Nov 12;8(11):e76504. doi: 10.1371/journal.pone.0076504. eCollection 2013. Erratum in: PLoS One. 2015;10(8):e0136810.


Reconstitution, activities, and structure of the eukaryotic RNA exosome.

Liu Q, Greimann JC, Lima CD.

Cell. 2006 Dec 15;127(6):1223-37. Erratum in: Cell. 2007 Oct 5;131(1):188-9.


Structure of the active subunit of the yeast exosome core, Rrp44: diverse modes of substrate recruitment in the RNase II nuclease family.

Lorentzen E, Basquin J, Tomecki R, Dziembowski A, Conti E.

Mol Cell. 2008 Mar 28;29(6):717-28. doi: 10.1016/j.molcel.2008.02.018.


Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing.

Wang HW, Wang J, Ding F, Callahan K, Bratkowski MA, Butler JS, Nogales E, Ke A.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16844-9. Epub 2007 Oct 17.


The eukaryotic RNA exosome.

Januszyk K, Lima CD.

Curr Opin Struct Biol. 2014 Feb;24:132-40. doi: 10.1016/ Epub 2014 Feb 11. Review.


The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase.

Schuch B, Feigenbutz M, Makino DL, Falk S, Basquin C, Mitchell P, Conti E.

EMBO J. 2014 Dec 1;33(23):2829-46. doi: 10.15252/embj.201488757. Epub 2014 Oct 15.


The yeast ski complex: crystal structure and RNA channeling to the exosome complex.

Halbach F, Reichelt P, Rode M, Conti E.

Cell. 2013 Aug 15;154(4):814-26. doi: 10.1016/j.cell.2013.07.017.


The RNA exosome complex central channel controls both exonuclease and endonuclease Dis3 activities in vivo and in vitro.

Drazkowska K, Tomecki R, Stodus K, Kowalska K, Czarnocki-Cieciura M, Dziembowski A.

Nucleic Acids Res. 2013 Apr 1;41(6):3845-58. doi: 10.1093/nar/gkt060. Epub 2013 Feb 12.


Rrp47 functions in RNA surveillance and stable RNA processing when divorced from the exoribonuclease and exosome-binding domains of Rrp6.

Garland W, Feigenbutz M, Turner M, Mitchell P.

RNA. 2013 Dec;19(12):1659-68. doi: 10.1261/rna.039388.113. Epub 2013 Oct 8.


RNA channelling by the eukaryotic exosome.

Malet H, Topf M, Clare DK, Ebert J, Bonneau F, Basquin J, Drazkowska K, Tomecki R, Dziembowski A, Conti E, Saibil HR, Lorentzen E.

EMBO Rep. 2010 Dec;11(12):936-42. doi: 10.1038/embor.2010.164. Epub 2010 Nov 12.


Crystal structure of a 9-subunit archaeal exosome in pre-catalytic states of the phosphorolytic reaction.

Lorentzen E, Conti E.

Archaea. 2012;2012:721869. doi: 10.1155/2012/721869. Epub 2012 Dec 20.


Structural components and architectures of RNA exosomes.

Januszyk K, Lima CD.

Adv Exp Med Biol. 2010;702:9-28. Review.

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