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MRX protects fork integrity at protein-DNA barriers, and its absence causes checkpoint activation dependent on chromatin context.

Bentsen IB, Nielsen I, Lisby M, Nielsen HB, Gupta SS, Mundbjerg K, Andersen AH, Bjergbaek L.

Nucleic Acids Res. 2013 Mar 1;41(5):3173-89. doi: 10.1093/nar/gkt051. Epub 2013 Feb 1.


Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.

Nakada D, Hirano Y, Sugimoto K.

Mol Cell Biol. 2004 Nov;24(22):10016-25.


MRX protects telomeric DNA at uncapped telomeres of budding yeast cdc13-1 mutants.

Foster SS, Zubko MK, Guillard S, Lydall D.

DNA Repair (Amst). 2006 Jul 13;5(7):840-51. Epub 2006 Jun 12.


Replication fork arrest and rDNA silencing are two independent and separable functions of the replication terminator protein Fob1 of Saccharomyces cerevisiae.

Bairwa NK, Zzaman S, Mohanty BK, Bastia D.

J Biol Chem. 2010 Apr 23;285(17):12612-9. doi: 10.1074/jbc.M109.082388. Epub 2010 Feb 23.


Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activation.

Grenon M, Magill CP, Lowndes NF, Jackson SP.

FEMS Yeast Res. 2006 Aug;6(5):836-47.


MRX (Mre11/Rad50/Xrs2) mutants reveal dual intra-S-phase checkpoint systems in budding yeast.

Andrews CA, Clarke DJ.

Cell Cycle. 2005 Aug;4(8):1073-7. Epub 2005 Aug 19.


The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress.

Tittel-Elmer M, Alabert C, Pasero P, Cobb JA.

EMBO J. 2009 Apr 22;28(8):1142-56. doi: 10.1038/emboj.2009.60. Epub 2009 Mar 12.


Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling.

Chen H, Donnianni RA, Handa N, Deng SK, Oh J, Timashev LA, Kowalczykowski SC, Symington LS.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1880-7. doi: 10.1073/pnas.1503331112. Epub 2015 Mar 23.


Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks.

Cannavo E, Cejka P.

Nature. 2014 Oct 2;514(7520):122-5. doi: 10.1038/nature13771. Epub 2014 Sep 17.


Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects.

Sogo JM, Lopes M, Foiani M.

Science. 2002 Jul 26;297(5581):599-602.


Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells.

Cotta-Ramusino C, Fachinetti D, Lucca C, Doksani Y, Lopes M, Sogo J, Foiani M.

Mol Cell. 2005 Jan 7;17(1):153-9.


The Mre11/Rad50/Xrs2 complex and non-homologous end-joining of incompatible ends in S. cerevisiae.

Zhang X, Paull TT.

DNA Repair (Amst). 2005 Nov 21;4(11):1281-94. Epub 2005 Jul 25.


Sir2p suppresses recombination of replication forks stalled at the replication fork barrier of ribosomal DNA in Saccharomyces cerevisiae.

BengurĂ­a A, HernĂ¡ndez P, Krimer DB, Schvartzman JB.

Nucleic Acids Res. 2003 Feb 1;31(3):893-8.


Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex.

Grenon M, Gilbert C, Lowndes NF.

Nat Cell Biol. 2001 Sep;3(9):844-7.


DNA replication-dependent nuclear dynamics of the Mre11 complex.

Mirzoeva OK, Petrini JH.

Mol Cancer Res. 2003 Jan;1(3):207-18.


Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks.

Shim EY, Chung WH, Nicolette ML, Zhang Y, Davis M, Zhu Z, Paull TT, Ira G, Lee SE.

EMBO J. 2010 Oct 6;29(19):3370-80. doi: 10.1038/emboj.2010.219. Epub 2010 Sep 10.


Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks.

Nicolette ML, Lee K, Guo Z, Rani M, Chow JM, Lee SE, Paull TT.

Nat Struct Mol Biol. 2010 Dec;17(12):1478-85. doi: 10.1038/nsmb.1957. Epub 2010 Nov 21.


Requirement of replication checkpoint protein kinases Mec1/Rad53 for postreplication repair in yeast.

Gangavarapu V, Santa Maria SR, Prakash S, Prakash L.

MBio. 2011 May 17;2(3):e00079-11. doi: 10.1128/mBio.00079-11. Print 2011.

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