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Results: 1 to 20 of 99

1.

Albumin stimulates the activity of the human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the effects are enzyme and substrate dependent.

Manevski N, Troberg J, Svaluto-Moreolo P, Dziedzic K, Yli-Kauhaluoma J, Finel M.

PLoS One. 2013;8(1):e54767. doi: 10.1371/journal.pone.0054767. Epub 2013 Jan 23.

PMID:
23372764
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Bovine serum albumin decreases Km values of human UDP-glucuronosyltransferases 1A9 and 2B7 and increases Vmax values of UGT1A9.

Manevski N, Moreolo PS, Yli-Kauhaluoma J, Finel M.

Drug Metab Dispos. 2011 Nov;39(11):2117-29. doi: 10.1124/dmd.111.041418. Epub 2011 Aug 19.

PMID:
21856742
[PubMed - indexed for MEDLINE]
Free Article
3.

Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases.

Manevski N, Kurkela M, Höglund C, Mauriala T, Court MH, Yli-Kauhaluoma J, Finel M.

Drug Metab Dispos. 2010 Mar;38(3):386-95. doi: 10.1124/dmd.109.031138. Epub 2009 Dec 10.

PMID:
20007669
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity.

Mutlib AE, Goosen TC, Bauman JN, Williams JA, Kulkarni S, Kostrubsky S.

Chem Res Toxicol. 2006 May;19(5):701-9.

PMID:
16696573
[PubMed - indexed for MEDLINE]
5.

Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases.

Kuuranne T, Kurkela M, Thevis M, Schänzer W, Finel M, Kostiainen R.

Drug Metab Dispos. 2003 Sep;31(9):1117-24.

PMID:
12920167
[PubMed - indexed for MEDLINE]
Free Article
6.

Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid.

Uchaipichat V, Mackenzie PI, Guo XH, Gardner-Stephen D, Galetin A, Houston JB, Miners JO.

Drug Metab Dispos. 2004 Apr;32(4):413-23. Erratum in: Drug Metab Dispos. 2005 Dec;33(12):1925-6.

PMID:
15039294
[PubMed - indexed for MEDLINE]
Free Article
7.

A high throughput assay for the glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes.

Rahikainen T, Häkkinen MR, Finel M, Pasanen M, Juvonen RO.

Xenobiotica. 2013 Oct;43(10):853-61. doi: 10.3109/00498254.2013.783724. Epub 2013 Apr 3.

PMID:
23551063
[PubMed - indexed for MEDLINE]
8.
9.

Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine.

Shiraga T, Yajima K, Suzuki K, Suzuki K, Hashimoto T, Iwatsubo T, Miyashita A, Usui T.

Drug Metab Dispos. 2012 Feb;40(2):276-82. doi: 10.1124/dmd.111.042614. Epub 2011 Oct 26.

PMID:
22031623
[PubMed - indexed for MEDLINE]
Free Article
10.

Uridine diphosphate glucuronosyltransferase isoform-dependent regiospecificity of glucuronidation of flavonoids.

Singh R, Wu B, Tang L, Hu M.

J Agric Food Chem. 2011 Jul 13;59(13):7452-64. doi: 10.1021/jf1041454. Epub 2011 Jun 6.

PMID:
21413806
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT).

Knights KM, Rowland A, Miners JO.

Br J Clin Pharmacol. 2013 Oct;76(4):587-602. doi: 10.1111/bcp.12086. Review.

PMID:
23362865
[PubMed - indexed for MEDLINE]
12.

Effect of albumin on human liver microsomal and recombinant CYP1A2 activities: impact on in vitro-in vivo extrapolation of drug clearance.

Wattanachai N, Tassaneeyakul W, Rowland A, Elliot DJ, Bowalgaha K, Knights KM, Miners JO.

Drug Metab Dispos. 2012 May;40(5):982-9. doi: 10.1124/dmd.111.044057. Epub 2012 Feb 13.

PMID:
22331994
[PubMed - indexed for MEDLINE]
Free Article
13.

The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan.

Alonen A, Finel M, Kostiainen R.

Biochem Pharmacol. 2008 Sep 15;76(6):763-72. doi: 10.1016/j.bcp.2008.07.006. Epub 2008 Jul 12.

PMID:
18674515
[PubMed - indexed for MEDLINE]
14.

Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases.

Sun D, Sharma AK, Dellinger RW, Blevins-Primeau AS, Balliet RM, Chen G, Boyiri T, Amin S, Lazarus P.

Drug Metab Dispos. 2007 Nov;35(11):2006-14. Epub 2007 Jul 30.

PMID:
17664247
[PubMed - indexed for MEDLINE]
Free Article
15.

Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.

Sneitz N, Vahermo M, Mosorin J, Laakkonen L, Poirier D, Finel M.

Drug Metab Dispos. 2013 Mar;41(3):582-91. doi: 10.1124/dmd.112.049072. Epub 2013 Jan 3.

PMID:
23288867
[PubMed - indexed for MEDLINE]
Free Article
16.

S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen.

Bowalgaha K, Elliot DJ, Mackenzie PI, Knights KM, Swedmark S, Miners JO.

Br J Clin Pharmacol. 2005 Oct;60(4):423-33.

PMID:
16187975
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases.

Kessler FK, Kessler MR, Auyeung DJ, Ritter JK.

Drug Metab Dispos. 2002 Mar;30(3):324-30.

PMID:
11854153
[PubMed - indexed for MEDLINE]
Free Article
18.

Human UDP-glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics.

Zhang H, Patana AS, Mackenzie PI, Ikushiro S, Goldman A, Finel M.

Drug Metab Dispos. 2012 Oct;40(10):1935-44. doi: 10.1124/dmd.112.046086. Epub 2012 Jul 10.

PMID:
22782802
[PubMed - indexed for MEDLINE]
Free Article
19.

Development of an assay using 4-trifluoromethylumbelliferyl as a marker substrate for assessment of drug-drug interactions to multiple isoforms of UDP-glucuronosyltransferases.

Baranczewski P, Kallin A, Andersson A, Hagigi S, Aberg M, Postlind H, Mankowitz L.

Assay Drug Dev Technol. 2004 Aug;2(4):345-52.

PMID:
15357915
[PubMed - indexed for MEDLINE]
20.

Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance.

Miners JO, McKinnon RA, Mackenzie PI.

Toxicology. 2002 Dec 27;181-182:453-6. Review.

PMID:
12505351
[PubMed - indexed for MEDLINE]

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