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APE1/Ref-1 prevents oxidative inactivation of ERK for G1-to-S progression following lead acetate exposure.

Wang YT, Tzeng DW, Wang CY, Hong JY, Yang JL.

Toxicology. 2013 Mar 8;305:120-9. doi: 10.1016/j.tox.2013.01.010. Epub 2013 Jan 28.


Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration.

Zou GM, Maitra A.

Mol Cancer Ther. 2008 Jul;7(7):2012-21. doi: 10.1158/1535-7163.MCT-08-0113.


Lead acetate induces EGFR activation upstream of SFK and PKCalpha linkage to the Ras/Raf-1/ERK signaling.

Wang CY, Wang YT, Tzeng DW, Yang JL.

Toxicol Appl Pharmacol. 2009 Mar 1;235(2):244-52. doi: 10.1016/j.taap.2008.12.007. Epub 2008 Dec 24.


APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.

Cardoso AA, Jiang Y, Luo M, Reed AM, Shahda S, He Y, Maitra A, Kelley MR, Fishel ML.

PLoS One. 2012;7(10):e47462. doi: 10.1371/journal.pone.0047462. Epub 2012 Oct 19.


Apurinic/apyrimidinic endonuclease 1 is a key modulator of keratinocyte inflammatory responses.

Lee HM, Yuk JM, Shin DM, Yang CS, Kim KK, Choi DK, Liang ZL, Kim JM, Jeon BH, Kim CD, Lee JH, Jo EK.

J Immunol. 2009 Nov 15;183(10):6839-48. doi: 10.4049/jimmunol.0901856. Epub 2009 Oct 21.


Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1.

Kelley MR, Luo M, Reed A, Su D, Delaplane S, Borch RF, Nyland RL 2nd, Gross ML, Georgiadis MM.

Antioxid Redox Signal. 2011 Apr 15;14(8):1387-401. doi: 10.1089/ars.2010.3410. Epub 2011 Jan 4.


Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines.

Cesaratto L, Codarin E, Vascotto C, Leonardi A, Kelley MR, Tiribelli C, Tell G.

PLoS One. 2013 Aug 15;8(8):e70909. doi: 10.1371/journal.pone.0070909. eCollection 2013.


The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress.

Vasko MR, Guo C, Kelley MR.

DNA Repair (Amst). 2005 Mar 2;4(3):367-79.


Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis.

Fishel ML, Colvin ES, Luo M, Kelley MR, Robertson KA.

Exp Hematol. 2010 Dec;38(12):1178-88. doi: 10.1016/j.exphem.2010.08.011. Epub 2010 Sep 6.


Activation of protein kinase Calpha signaling prevents cytotoxicity and mutagenicity following lead acetate in CL3 human lung cancer cells.

Wang CY, Lin YW, Yang JL.

Toxicology. 2008 Aug 19;250(1):55-61. doi: 10.1016/j.tox.2008.06.001. Epub 2008 Jun 11.


Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth.

Fishel ML, Jiang Y, Rajeshkumar NV, Scandura G, Sinn AL, He Y, Shen C, Jones DR, Pollok KE, Ivan M, Maitra A, Kelley MR.

Mol Cancer Ther. 2011 Sep;10(9):1698-708. doi: 10.1158/1535-7163.MCT-11-0107. Epub 2011 Jun 23.


Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity.

Li Y, Liu X, Zhou T, Kelley MR, Edwards PA, Gao H, Qiao X.

Invest Ophthalmol Vis Sci. 2014 Jun 26;55(7):4461-9. doi: 10.1167/iovs.14-14451.


Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function.

Vascotto C, Bisetto E, Li M, Zeef LA, D'Ambrosio C, Domenis R, Comelli M, Delneri D, Scaloni A, Altieri F, Mavelli I, Quadrifoglio F, Kelley MR, Tell G.

Mol Biol Cell. 2011 Oct;22(20):3887-901. doi: 10.1091/mbc.E11-05-0391. Epub 2011 Aug 24.


Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway.

Cesaratto L, Calligaris SD, Vascotto C, Deganuto M, Bellarosa C, Quadrifoglio F, Ostrow JD, Tiribelli C, Tell G.

J Mol Med (Berl). 2007 Oct;85(10):1099-112. Epub 2007 May 4.


Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth.

Fishel ML, He Y, Reed AM, Chin-Sinex H, Hutchins GD, Mendonca MS, Kelley MR.

DNA Repair (Amst). 2008 Feb 1;7(2):177-86. Epub 2007 Oct 31.


The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate.

Domenis R, Bergamin N, Gianfranceschi G, Vascotto C, Romanello M, Rigo S, Vagnarelli G, Faggiani M, Parodi P, Kelley MR, Beltrami CA, Cesselli D, Tell G, Beltrami AP.

PLoS One. 2014 Feb 19;9(2):e89232. doi: 10.1371/journal.pone.0089232. eCollection 2014.


Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1.

Luo M, Delaplane S, Jiang A, Reed A, He Y, Fishel M, Nyland RL 2nd, Borch RF, Qiao X, Georgiadis MM, Kelley MR.

Antioxid Redox Signal. 2008 Nov;10(11):1853-67. doi: 10.1089/ars.2008.2120.


Radiation resistance in glioma cells determined by DNA damage repair activity of Ape1/Ref-1.

Naidu MD, Mason JM, Pica RV, Fung H, Peña LA.

J Radiat Res. 2010;51(4):393-404.


Redox effector factor-1, combined with reactive oxygen species, plays an important role in the transformation of JB6 cells.

Yang S, Misner BJ, Chiu RJ, Meyskens FL Jr.

Carcinogenesis. 2007 Nov;28(11):2382-90. Epub 2007 Jun 12.

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